Results 11 to 20 of about 1,205 (207)

A synergetic effect of sonication with yolk-shell nanocatalyst for green synthesis of spirooxindoles

Green Chemistry Letters and Reviews, 2021
A synergetic effect of ultrasonic irradiation and yolk–shell nanocatalyst was examined for the synthesis of spirooxindoles from isatin, malononitrile and cyclohexanone.
Somaye Mohammadi, Hossein Naeimi
doaj   +2 more sources

Catalytic asymmetric synthesis of spirooxindoles: recent developments

Chemical Communications, 2018
The past four years have witnessed significant developments in the field of the catalytic asymmetric synthesis of spirooxindoles, and this feature article outlines the recent progress in this area, including the contributions of our group. This article is divided into sections according to the size and type of the generated spiro-ring fused at the C3 ...
Guang-Jian Mei, Feng Shi
openaire   +3 more sources

Organocatalytic Access to Enantioenriched Spirooxindole-Based 4-Methyleneazetidines [PDF]

Molecules, 2017
This work describes the synthesis of enantioenriched spiro compounds, incorporating the azetidine and the oxindole motifs. The preparation relies on a formal [2 + 2] annulation reaction of isatin-derived N-tert-butylsulfonyl ketimines with allenoates ...
Giulia Rainoldi, Matteo Faltracco, Claudia Spatti, Alessandra Silvani, Giordano Lesma   +4 more
doaj   +3 more sources

Pyrrolizine- and Indolizine-Derived Spirooxindoles: Synthesis, Antibacterial Activity and Inverse Docking Analysis

Chemistry
Spirooxindoles are a family of heterocyclic compounds which bear the oxindole nucleus in their structures, which have a considerable pharmaceutical potential and which have been linked to various drugs for the treatment of diverse diseases. In this work,
Pablo Romo, María del Pilar Crespo, Mauricio Barreto, María Elena Burbano, Melissa Mejia-Gutierrez, Jairo Quiroga, Rodrigo Abonia   +6 more
doaj   +2 more sources

Spirooxindoles as Disruptors of Preformed Hen Egg White Lysozyme Fibrils as a Model for Neurodegenerative Diseases. [PDF]

ChemMedChem
Formation of fibrils is a key factor in the development of neurodegenerative diseases. Their highly ordered structure is stabilized by strong hydrogen bonding. Synthesised spirooxindole compounds, Hd‐63, Hd‐66, and Hd‐74, disrupt fibril structure, leading to the breakdown of this order and promoting the formation of off‐pathway aggregates that lack ...
Dahdah A, de Silva NH, Blanch EW, Maniam S.   +3 more
europepmc   +2 more sources

Copper- and Silver-Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five- and Six-Membered Heterocycles. [PDF]

Chemistry
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
George J, Oh K.
europepmc   +2 more sources

In Vitro and In Silico Evaluation of Isatin-Derived Spirooxindoles as Antituberculosis Drug Candidates. [PDF]

Chem Biol Drug Des
Two compounds, A16 and A17, were active against multidrug‐resistant Mycobacterium tuberculosis isolates (PT‐12 and PT‐20), overcoming key resistance mutations in katG and rpoB, while cytotoxicity assays confirmed that they are non‐toxic. A17 exhibited the highest antituberculosis activity, with molecular docking suggesting enoyl‐[acyl‐carrier‐protein ...
de Lima FR, de Oliveira Viana J, de Castro AC, Cristiano R, Perelló MA, Czeczot AM, Bizarro CV, Machado P, Basso LA, Lima-Junior CG, Rodrigues-Junior VDS, Weber KC.   +11 more
europepmc   +2 more sources

Deciphering Tryptophan Oxygenation: Key Modulators of 2-Oxindole Formation in MarE. [PDF]

Angew Chem Int Ed Engl
This study reveals that MarE, a heme‐dependent aromatic oxygenase, favors dioxygenation of β‐methyl‐l‐tryptophan in the absence of ascorbate and demonstrates how structural and redox tuning shifts its reactivity toward selective monooxygenation, yielding a 2‐oxindole scaffold. These findings offer new insights into enzyme‐controlled indole oxidation in
Nguyen RC, Shin I, Liu A.
europepmc   +3 more sources

Highly diastereoselective cascade [5 + 1] double Michael reaction, a route for the synthesis of spiro(thio)oxindoles

Scientific Reports, 2021
The first diastereoselective synthesis of spirothiooxindoles is reported via the Michael reaction between thiooxindoles and dibenzalacetones. The reaction was conducted without any catalyst or additive under green conditions, i.e., ethanol as the solvent
Firouz Matloubi Moghaddam, Vahid Saberi, Ashkan Karimi   +2 more
doaj   +1 more source

A Molecular Electron Density Theory Study of the [3+2] Cycloaddition Reaction of an Azomethine Ylide with an Electrophilic Ethylene Linked to Triazole and Ferrocene Units

Molecules, 2022
The [3+2] cycloaddition (32CA) reaction of an azomethine ylide (AY) with an electrophilic ethylene linked to triazole and ferrocene units has been studied within the Molecular Electron Density Theory (MEDT) at the ωB97X-D/6-311G(d,p) level.
Luis R. Domingo, Mar Ríos-Gutiérrez, Assem Barakat   +2 more
doaj   +1 more source