Results 11 to 20 of about 555 (125)

Spirooxindoles as Disruptors of Preformed Hen Egg White Lysozyme Fibrils as a Model for Neurodegenerative Diseases. [PDF]

ChemMedChem
Formation of fibrils is a key factor in the development of neurodegenerative diseases. Their highly ordered structure is stabilized by strong hydrogen bonding. Synthesised spirooxindole compounds, Hd‐63, Hd‐66, and Hd‐74, disrupt fibril structure, leading to the breakdown of this order and promoting the formation of off‐pathway aggregates that lack ...
Dahdah A, de Silva NH, Blanch EW, Maniam S.   +3 more
europepmc   +2 more sources

Spirooxindole 5-(Trifluoromethyl)benzothiazole Hybrids: Synthesis, Crystal Structure, and Antioxidant Activity. [PDF]

Arch Pharm (Weinheim)
The antioxidant activities of novel 5‐(trifluoromethyl)‐3H‐spiro[1,3‐benzothiazole‐2,3′‐indol]‐2′(1′H)‐ones (4a–h), along with the previously synthesized spirocyclic 2‐indolinones (4i–m and 5a–n), were investigated to find a multi‐modal antioxidant and to understand the impact of the trifluoromethyl group located at the 5‐position of the benzothiazole ...
Karabag N, Temizer-Keser AB, Pekmez M, Mertoğlu-Kamalı E, Kaynak FB, Özsoy N, Arda N, Karalı N.   +7 more
europepmc   +2 more sources

Copper- and Silver-Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five- and Six-Membered Heterocycles. [PDF]

Chemistry
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
George J, Oh K.
europepmc   +2 more sources

In Vitro and In Silico Evaluation of Isatin-Derived Spirooxindoles as Antituberculosis Drug Candidates. [PDF]

Chem Biol Drug Des
Two compounds, A16 and A17, were active against multidrug‐resistant Mycobacterium tuberculosis isolates (PT‐12 and PT‐20), overcoming key resistance mutations in katG and rpoB, while cytotoxicity assays confirmed that they are non‐toxic. A17 exhibited the highest antituberculosis activity, with molecular docking suggesting enoyl‐[acyl‐carrier‐protein ...
de Lima FR, de Oliveira Viana J, de Castro AC, Cristiano R, Perelló MA, Czeczot AM, Bizarro CV, Machado P, Basso LA, Lima-Junior CG, Rodrigues-Junior VDS, Weber KC.   +11 more
europepmc   +2 more sources

3′-Methyl-2-oxo-1′,5′-diphenyl-1′,7′-dihydrospiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-6′-carboxylic Acid

Molbank, 2021
3′-methyl-2-oxo-1′,5′-diphenyl-1′,7′-dihydrospiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-6′-carboxylic acid was synthesized using diverse conditions. The best reaction condition consisted of using water as solvent under microwave irradiation, affording ...
Pablo E. Romo, Braulio Insuasty, Jairo Quiroga, Rodrigo Abonia   +3 more
doaj   +1 more source

Synthesis and Characterization of New Spirooxindoles Including Triazole and Benzimidazole Pharmacophores via [3+2] Cycloaddition Reaction: An MEDT Study of the Mechanism and Selectivity

Molecules, 2023
A new series of spirooxindoles based on benzimidazole, triazole, and isatin moieties were synthesized via a [3+2] cycloaddition reaction protocol in one step. The single X-ray crystal structure of the intermediate triazole-benzimidazole 4 was solved. The
Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, M. Ali, Mezna Saleh Altowyan, Mar Ríos-Gutiérrez, Sammer Yousuf, Assem Barakat   +7 more
doaj   +1 more source

3′,4′-Dihydro-2′H-spiro[indoline-3,1′-isoquinolin]-2-ones as potential anti-cancer agents: synthesis and preliminary screening [PDF]

Royal Society Open Science, 2020
Both tetrahydroisoquinolines (THIQs) and oxindoles (OXs) display a broad range of biological activities including anti-cancer activity, and are therefore recognized as two privileged scaffolds in drug discovery. In the present study, 24 3′,4′-dihydro-2′H-
Maloba M. M. Lobe, Simon M. N. Efange
doaj   +1 more source

The Solubility Studies and the Complexation Mechanism Investigations of Biologically Active Spiro[cyclopropane-1,3′-oxindoles] with β-Cyclodextrins

Pharmaceutics, 2023
In this work, we first improved the aqueous solubility of biologically active spiro[cyclopropane-1,3′-oxindoles] (SCOs) via their complexation with different β-cyclodextrins (β-CDs) and proposed a possible mechanism of the complex formation.
Anna A. Kravtsova, Anna A. Skuredina, Alexander S. Malyshev, Irina M. Le-Deygen, Elena V. Kudryashova, Ekaterina M. Budynina   +5 more
doaj   +1 more source

Synthesis of new functionalized thiazolo pyridine-fused and thiazolo pyridopyrimidine-fused spirooxindoles via one-pot reactions

Heliyon, 2020
A sequential multi-component reaction of the nitroketene dithioacetals, cysteamine hydrochloride, isatin and different CH-acids is described. This efficient method provides new functionalized thiazolo pyridine-fused spirooxindoles and thiazolo ...
Shima Nasri, Mohammad Bayat, Hassan Vasheghani Farahani, Solmaz Karami   +3 more
doaj   +1 more source

A Molecular Electron Density Theory Study of the [3+2] Cycloaddition Reaction of an Azomethine Ylide with an Electrophilic Ethylene Linked to Triazole and Ferrocene Units

Molecules, 2022
The [3+2] cycloaddition (32CA) reaction of an azomethine ylide (AY) with an electrophilic ethylene linked to triazole and ferrocene units has been studied within the Molecular Electron Density Theory (MEDT) at the ωB97X-D/6-311G(d,p) level.
Luis R. Domingo, Mar Ríos-Gutiérrez, Assem Barakat   +2 more
doaj   +1 more source