Results 11 to 20 of about 1,887 (208)

Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold [PDF]

Molecules, 2023
Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways.
Siva S. Panda, Adel S. Girgis, Marian N. Aziz, Mohamed S. Bekheit   +3 more
doaj   +4 more sources

The Therapeutic Potential of Spirooxindoles in Cancer: A Focus on p53–MDM2 Modulation [PDF]

Pharmaceuticals
The p53, often referred to as the “guardian of the genome”, is a well-established tumor-suppressor protein that plays a critical role in regulating the cell cycle, DNA repair, differentiation, and apoptosis, with its activity primarily modulated by the ...
Adel S. Girgis, Yujun Zhao, Angel Nkosi, Nasser S. M. Ismail, Mohamed S. Bekheit, Dalia R. Aboshouk, Marian N. Aziz, M. Adel Youssef, Siva S. Panda   +8 more
doaj   +2 more sources

Preparation of spirocyclic oxindoles by cyclisation of an oxime to a nitrone and dipolar cycloaddition [PDF]

Beilstein Journal of Organic Chemistry
Oxindoles are an important class of compounds with significant biological activities. Spirocyclic derivatives are present in a variety of natural products.
Beth L. Ritchie, Alexandra Longcake, Iain Coldham   +2 more
doaj   +2 more sources

Synthesis, Biological and In Silico Evaluation of Pure Nucleobase-Containing Spiro (Indane-Isoxazolidine) Derivatives as Potential Inhibitors of MDM2–p53 Interaction [PDF]

Molecules, 2019
Nucleobase-containing isoxazolidines spiro-bonded to an indane core have been synthesized in very good yields by regio- and diastereoselective 1,3-dipolar cycloaddition starting from indanyl nitrones and N-vinylnucleobases by using environmentally benign
Loredana Maiuolo, Vincenzo Algieri, Beatrice Russo, Matteo Antonio Tallarida, Monica Nardi, Maria Luisa Di Gioia, Zahra Merchant, Pedro Merino, Ignacio Delso, Antonio De Nino   +9 more
doaj   +3 more sources

Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation [PDF]

Frontiers in Chemistry, 2021
The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and induce apoptosis.
Yasmine M. Abdel Aziz, Gehad Lotfy, Mohamed M. Said, El Sayed H. El Ashry, El Sayed H. El Tamany, Saied M. Soliman, Marwa M. Abu-Serie, Mohamed Teleb, Sammer Yousuf, Alexander Dömling, Luis R. Domingo, Assem Barakat   +11 more
doaj   +3 more sources

One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with limited treatment options due to its heterogeneity and the lack of well-defined molecular targets.
Wagdy M Eldehna, Ahmed R Hamed, Hany S Ibrahim   +2 more
exaly   +2 more sources

Asymmetric Synthesis of Spirooxindoles via Nucleophilic Epoxidation Promoted by Bifunctional Organocatalysts [PDF]

Molecules, 2018
Taking into account the postulated reaction mechanism for the organocatalytic epoxidation of electron-poor olefins developed by our laboratory, we have investigated the key factors able to positively influence the H-bond network installed inside the ...
Martina Miceli, Andrea Mazziotta, Chiara Palumbo, Elia Roma, Eleonora Tosi, Giovanna Longhi, Sergio Abbate, Paolo Lupattelli, Giuseppe Mazzeo, Tecla Gasperi   +9 more
doaj   +7 more sources

Organocatalytic Access to Enantioenriched Spirooxindole-Based 4-Methyleneazetidines [PDF]

Molecules, 2017
This work describes the synthesis of enantioenriched spiro compounds, incorporating the azetidine and the oxindole motifs. The preparation relies on a formal [2 + 2] annulation reaction of isatin-derived N-tert-butylsulfonyl ketimines with allenoates ...
Giulia Rainoldi, Matteo Faltracco, Claudia Spatti, Alessandra Silvani, Giordano Lesma   +4 more
doaj   +3 more sources

Base-Catalyzed Reaction of Isatins and (3-Hydroxyprop-1-yn-1-yl)phosphonates as a Tool for the Synthesis of Spiro-1,3-dioxolane Oxindoles with Anticancer and Anti-Platelet Properties [PDF]

Molecules
An approach to the synthesis of phosphoryl substituted spiro-1,3-dioxolane oxindoles was developed from the base-catalyzed reaction of various isatins with (3-hydroxyprop-1-yn-1-yl)phosphonates.
Arina V. Murashkina, Andrei V. Bogdanov, Alexandra D. Voloshina, Anna P. Lyubina, Alexandr V. Samorodov, Alexander Y. Mitrofanov, Irina P. Beletskaya, Elena A. Smolyarchuk, Kseniya A. Zavadich, Zulfiya A. Valiullina, Kseniya A. Nazmieva, Vladislav I. Korunas, Irina D. Krylova   +12 more
doaj   +2 more sources

Quantitative structure-activity relationship and ADME prediction studies on series of spirooxindoles derivatives for anti-cancer activity against colon cancer cell line HCT-116 [PDF]

Heliyon
Forty-one derivatives of spirooxindoles, active against HCT-116 colon cancer cells, underwent pharmacophore-based 3D-QSAR analysis to understand their correlation with anti-cancer activity. The study identified a seven-point pharmacophore model (ADHHRRR1)
Sukhmeet Kaur, Jasneet Kaur, Bilal Ahmad Zarger, Nasarul Islam, Nazirah Mir   +4 more
doaj   +2 more sources