Results 21 to 30 of about 582 (169)

Electrochemical Enantioselective Oxidation of Indoles via Chiral Phosphoric Acid Catalysis in Cooperation with H₃PO₄ in Aqueous Media. [PDF]

Angew Chem Int Ed Engl
A binary organic–inorganic acid cooperative catalytic system has been developed to achieve highly enantioselective electrochemical oxidative rearrangement of indoles. The use of electricity as an oxidant in this case showed several advantages including environmental benignity and improved enantiocontrol.
Tan X, Zhou Z, Shao M, Sun J.
europepmc   +2 more sources

Synthesis of new functionalized thiazolo pyridine-fused and thiazolo pyridopyrimidine-fused spirooxindoles via one-pot reactions

Heliyon, 2020
A sequential multi-component reaction of the nitroketene dithioacetals, cysteamine hydrochloride, isatin and different CH-acids is described. This efficient method provides new functionalized thiazolo pyridine-fused spirooxindoles and thiazolo ...
Shima Nasri, Mohammad Bayat, Hassan Vasheghani Farahani, Solmaz Karami   +3 more
doaj   +1 more source

A Molecular Electron Density Theory Study of the [3+2] Cycloaddition Reaction of an Azomethine Ylide with an Electrophilic Ethylene Linked to Triazole and Ferrocene Units

Molecules, 2022
The [3+2] cycloaddition (32CA) reaction of an azomethine ylide (AY) with an electrophilic ethylene linked to triazole and ferrocene units has been studied within the Molecular Electron Density Theory (MEDT) at the ωB97X-D/6-311G(d,p) level.
Luis R. Domingo, Mar Ríos-Gutiérrez, Assem Barakat   +2 more
doaj   +1 more source

Synthesis of Tetracyclic Spirooxindolepyrrolidine-Engrafted Hydantoin Scaffolds: Crystallographic Analysis, Molecular Docking Studies and Evaluation of Their Antimicrobial, Anti-Inflammatory and Analgesic Activities

Molecules, 2023
In a sustained search for novel potential drug candidates with multispectrum therapeutic application, a series of novel spirooxindoles was designed and synthesized via regioselective three-component reaction between isatin derivatives, 2-phenylglycine ...
Amani Toumi, Faiza I.A. Abdella, Sarra Boudriga, Tahani Y. A. Alanazi, Asma K. Alshamari, Ahlam Abdulrahman Alrashdi, Amal Dbeibia, Khaled Hamden, Ismail Daoud, Michael Knorr, Jan-Lukas Kirchhoff, Carsten Strohmann   +11 more
doaj   +1 more source

Transition metal-catalyzed synthesis of spirooxindoles

RSC Advances, 2021
Spirooxindoles are used as anticancer-, antiviral-, antimicrobial agents etc. The use of transition metals as catalysts for the synthesis of spirooxindoles is advancing rapidly. Here, we focus on recent advances in transition metal-catalyzed synthesis of spirooxindoles.
P. V. Saranya, Mohan Neetha, Thaipparambil Aneeja, Gopinathan Anilkumar   +3 more
openaire   +3 more sources

An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction

Molecules, 2015
A series of hitherto unreported anthracene-embedded dispirooxindoles has been synthesized via a one-pot three-component 1,3-dipolar cycloaddition reaction of an azomethine ylide, generated in situ from the reaction of isatin and sarcosine to 10 ...
Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, J. Carlos Menéndez, Mujeeb A. Sultan, Usama Karama, Hazem A. Ghabbour, Hoong-Kun Fun   +7 more
doaj   +1 more source

One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with limited treatment options due to its heterogeneity and the lack of well-defined molecular targets.
Wagdy M. Eldehna, Dina H. EL-Naggar, Ahmed R. Hamed, Hany S. Ibrahim, Hazem A. Ghabbour, Hatem A. Abdel-Aziz   +5 more
doaj   +1 more source

A synergetic effect of sonication with yolk-shell nanocatalyst for green synthesis of spirooxindoles

Green Chemistry Letters and Reviews, 2021
A synergetic effect of ultrasonic irradiation and yolk–shell nanocatalyst was examined for the synthesis of spirooxindoles from isatin, malononitrile and cyclohexanone.
Somaye Mohammadi, Hossein Naeimi
doaj   +1 more source

The Synthesis of 3-Spirooxindole Derivatives. IV. The Conversion of 3-Spirooxindole to Indole Derivative.

Chemical and Pharmaceutical Bulletin, 1963
The conversion of 1-methylspiro (indoline-3, 1'-indolizine)-2-one to 12-methyl-1, 2, 3, 4, 6, 7, 12, 12b-octahydroindolo [2, 3-a] quinolizine is described as a preliminary for the chemical correlation of N-methylrhynchophyllane with N-methyldihydrocorynantheane.
Oishi, Takeshi, Maeno, Shizuo, Ban, Yoshio   +2 more
openaire   +3 more sources

An Efficient Synthesis of Oxygen-Bridged Spirooxindoles via Microwave-Promoted Multicomponent Reaction

Molecules, 2023
A microwave-promoted multicomponent reaction of isatins, α-amino acids and 1,4-dihydro-1,4-epoxynaphthalene is achieved under environmentally friendly conditions, delivering oxygen-bridged spirooxindoles within 15 min in good to excellent yields.
Yaojing Shi, Hua Zhao, Yufen Zhao
doaj   +1 more source