Diversity-oriented synthesis as a tool for identifying new modulators of mitosis. [PDF]
, 2014 The synthesis of diverse three-dimensional libraries has become of paramount importance for obtaining better leads for drug discovery. Such libraries are predicted to fare better than traditional compound collections in phenotypic screens and against ...
Alza, Esther +8 more
core +1 more source
Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity [PDF]
, 2021 Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry.
Brandão, Pedro +4 more
core +1 more source
Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds [PDF]
, 2016 Commercially available iron (III) and copper (I) complexes catalyze new multicomponent cycloadditions between diazo compounds, pyridines and electrophilic alkenes to give alkaloid-inspired tetrahydroindolizidines in high yields and diastereoselectivities.
Aggarwal +29 more
core +1 more source
A synergetic effect of sonication with yolk-shell nanocatalyst for green synthesis of spirooxindoles
Green Chemistry Letters and Reviews, 2021 A synergetic effect of ultrasonic irradiation and yolk–shell nanocatalyst was examined for the synthesis of spirooxindoles from isatin, malononitrile and cyclohexanone.
Somaye Mohammadi, Hossein Naeimi
doaj +1 more source
Studies on the Enantioselective Synthesis of E-Ethylidene-bearing Spiro[indolizidine-1,3′-oxindole] Alkaloids [PDF]
, 2021 A synthetic route for the enantioselective construction of the tetracyclic spiro[indolizidine-1,3'-oxindole] framework present in a large number of oxindole alkaloids, with a cis H-3/H-15 stereochemistry, a functionalized two-carbon substituent at C-15 ...
Amat Tusón, Mercedes +4 more
core +1 more source
Molecules, 2015 A series of hitherto unreported anthracene-embedded dispirooxindoles has been synthesized via a one-pot three-component 1,3-dipolar cycloaddition reaction of an azomethine ylide, generated in situ from the reaction of isatin and sarcosine to 10 ...
Natarajan Arumugam +7 more
doaj +1 more source
Molecules, 2023 A microwave-promoted multicomponent reaction of isatins, α-amino acids and 1,4-dihydro-1,4-epoxynaphthalene is achieved under environmentally friendly conditions, delivering oxygen-bridged spirooxindoles within 15 min in good to excellent yields.
Yaojing Shi, Hua Zhao, Yufen Zhao
doaj +1 more source
Asymmetric 1,3-Dipolar Cycloadditons of Stabilized Azomethine Ylides with Nitroalkenes [PDF]
, 2014 This review highlights the biological importance of many polysubstituted nitro-prolines and -pyrrolidines. Their preparation using asymmetric 1,3-dipolar cycloadditions of azomethine ylides with nitroalkenes using diastereoselective and enantioselective ...
Nájera, Carmen, Sansano, Jose M.
core +2 more sources
Sonochemical multi-component synthesis of spirooxindoles
Ultrasonics Sonochemistry, 2011 New and efficient multi-component methods have been developed for the synthesis of spirooxindoles in the presence of a catalytic amount of p-TSA as an inexpensive and available catalyst in EtOH under ultrasound irradiation. The method is simple, starts from readily accessible commercial starting materials, and provides biologically interesting products
Minoo, Dabiri +3 more
openaire +2 more sources
Metal-Free Diastereo- and Enantioselective Dearomative Formal [3+2] Cycloaddition of 2-Nitrobenzofurans and Isocyanoacetate Esters [PDF]
, 2022 [EN] The diastereo- and enantioselective dearomative formal [3 + 2] cycloaddition of 2-nitrobenzofurans and alpha-aryl-alpha isocyanoacetate esters provides tricyclic compounds bearing the 3a,8b-dihydro-1H-benzofuro[2,3-c]pyrrole framework with three ...
Blay, Gonzalo +5 more
core +4 more sources