Results 101 to 110 of about 1,205 (207)
BMC ChemistryThe synthesis of Octakis [3- (3-amino propyl triethoxysilane) propyl] octa-silsesquioxane (APTPOSS), a derivative of polyhedral oligomeric silsesquioxane, was utilized to produce an efficient nanocomposite.
Samira Moein-Najafabadi +1 more
doaj +1 more source
Nanoformulation of Spirooxindole and Methods for Treating Hepatocellular Carcinoma
PharmaceuticsObjectives: This in vivo study introduces a newly developed spirooxindole derivative that is deemed safe and effective as a potential targeted therapy for various cancers. Methods: Extensive in vivo investigations, including histopathology, immunohistochemistry, and molecular biology, validated its potential for further preclinical and clinical ...
Assem Barakat +6 more
openaire +3 more sources
, 2016 A metal-free oxidative spirocyclization of hydroxymethylacrylamide with 1,3-dicarbonyl compounds is described. The reaction proceeds through tandem dual C–H functionalization and intramolecular dehydration, in which two new C–C bonds and one C–O bond ...
Xin-Hua Duan (1392880) +2 more
core +1 more source
A palladium-catalyzed oxidative carbo-heterofunctionalization of aniline derivs. involving concomitant direct C-H functionalization and C-X bond formation was developed.
Duan, Xin-Hua +7 more
core +1 more source
, 2015 International audienceA recyclable fluorous bifunctional Cinchona alkaloid/thiourea-catalyzed and four-component Michael/Mannich/cyclization sequence has been developed for the asymmetric synthesis of spirooxindoles containing 2-piperidinone and ...
Huang, Xin +8 more
core +1 more source
, 2018 The first highly diastereoselective Michael addition/condensation/Friedel–Crafts alkylation cascade reaction of 3-indolyl-substituted oxindoles with ortho-hydroxychalcones was established, which afforded a wide range of polycyclic indole-bridged chroman ...
Zhanwei Bu (4975538) +3 more
core +1 more source
The present report demonstrates an efficient use of bentonite clay to bring about multicomponent synthesis of substituted spirooxindoles 4a-h in Water/ ethanol solvent system under the mild reaction conditions.
Bhatia, Sunil +3 more
core +1 more source
, 2017 An efficient method for the construction of pyrrolidinyl spirooxindoles with 3-isothiocyanato oxindoles and chalcones via a Michael/cyclization cascade reaction has been developed using squaramide. The products were obtained in high yields with excellent
Lei Liu, Ye Lin, Da-Ming Du
core +1 more source
Molecular diversity of spirooxindoles. Synthesis and biological activity [PDF]
, 2016 Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the ...
Редькін, Р. Г. +10 more
core
An investigatory study of antibacterial activity of functionalized spirooxindoles
, 2014 399-411Synthesis of functionalized spirooxindoles have been reviewed and it has been proposed that the unique core ring system that is common to this family of compounds arises by a biological Knoevengal-Michael-Domino cyclization along with the ...
Luthra, Pratibha Mehta +4 more
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