Results 101 to 110 of about 1,887 (208)
Chemistry – An Asian Journal, Volume 20, Issue 8, April 17, 2025.In this review, the advancements in the cyclization of 1,3‐enynes to construct structurally diverse heterocyclic and carbocyclic frameworks are portrayed comprehensively. Divergent cyclization protocols along with mechanistic aspects for key transformations are also detailed. Abstract 1,3‐Enynes have demonstrated their utility as valuable precursors to
Akash P. Sakla +4 more
wiley +1 more source
Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles [PDF]
Organic Letters, 2010 The Lewis acid-catalyzed, three-component reaction of isatin and two 1,3-dicarbonyl compounds is reported. Reactions proceed with high efficiency under mild reaction conditions and with good functional group tolerance to afford spirooxindole pyranochromenedione derivatives.
Bo, Liang +3 more
openaire +2 more sources
Cooperative Vinylogous Enamine and Metal Catalysis
ChemCatChem, Volume 17, Issue 7, April 4, 2025.This review describes transformations combining vinylogous enamine catalysis with transition metal or Lewis acid catalysis that have emerged since the seminal report of dienamine catalysis in 2006. These transformations span numerous reaction classes, including alkylation, allylation, propargylation, oxyamination, dimerization, as well as cascade ...
Stacey E. Brenner‐Moyer
wiley +1 more source
Dynamic stereoselective annulation via aldol-oxa-cyclization cascade reaction to afford spirooxindole pyran polycycles [PDF]
, 2019 Spiro polycyclic compounds bearing pyran ring systems are found in bioactive molecules, and we recently reported the construction of spirooxindole all-carbon polycycles.
Fujie Tanaka, Muhammad Sohail
core +2 more sources
Microwave‐Assisted Multicomponent Synthesis of Spirooxindole Dihydropyridine Bisphosphonates
European Journal of Organic Chemistry, Volume 28, Issue 6, February 10, 2025.A new, simple, catalyst‐ and solvent‐free microwave‐assisted multicomponent method was developed for the synthesis of spirooxindole dihydropyridine bisphosphonates as a new family of compounds by the one‐pot reaction of isatins, β‐ketophosphonates and primary amines.
Bettina Rávai +3 more
wiley +1 more source
An evaluation of spirooxindoles as blocking agents of SARS-CoV-2 spike/ACE2 interaction : synthesis, biological evaluation and computational analysis [PDF]
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained significant public health attention owing to its devastating effects on lives and livelihoods worldwide.
Cassel, Joel +11 more
core +1 more source
Synthetic Methodologies Using Nucleophile-Electrophile Chemistry [PDF]
, 2023 Synthetic organic chemistry is a vital part of the modern world – making up 15-20% of the U.S. economy. New synthetic reactions can lower manufacturing costs and create more environmentally friendly processes.
Hood, Jacob C.
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Heteroatom Chemistry, Volume 2025, Issue 1, 2025.A convenient approach for the synthesis of 2‐acetyl‐4‐phenylquinoline designed monospiro‐pyrrolidine/thiapyrrolizidine hybrids has been achieved via a 1,3‐dipolar cycloaddition reaction of various azomethine ylides derived from isatin/acenaphthylene‐1,2‐dione/ninhydrin, ortho‐phenylenediamine and sarcosine/L‐4‐thiazolidinecarboxylic acid with 2‐acetyl ...
Satheeshkumar Rajendran +3 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2010 The synthesis of C3-carbocyclic spirooxindoles was realized by way of an intramolecular [2 + 2] cycloaddition reaction between a vinylidene indolin-2-one and an alkyne.
Kay M. Brummond, Joshua M. Osbourn
doaj +1 more source
Novel concepts and methodologies in pseudo natural product chemistry [PDF]
, 2021 Natural products (NPs) are an inspiring source for chemical biology and drug discovery research, featuring complex and diverse structures. However, the chemical space explored by nature is limited by the biosynthetic precursors and machineries available ...
Liu, Jie
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