Results 161 to 170 of about 37,352 (250)

Transcriptome-wide interrogation of the functional intronome by spliceosome profiling

, 2017
SUMMARYFull understanding of eukaryotic transcriptomes and how they respond to different conditions requires deep knowledge of all sites of intron excision. Although RNA-Seq provides much of this information, the low abundance of many spliced transcripts
Hakan Ozadam, Melissa J. Moore, Weijun Chen, Jill Moore, Nicholas Rhind, Hennady P. Shulha, Zhiping Weng   +6 more
core   +1 more source

Editorial: Therapeutic targeting of splicing variants in cancer

Frontiers in Pharmacology, 2023
Pouya Sarvari, Karla Rubio, Karla Rubio, Stephanie Dobersch, Aglaia Ntokou, Aglaia Ntokou, Verónica Vallejo-Ruiz   +6 more
doaj   +1 more source

Clinical management of clonal hematopoiesis

Cancer, Volume 132, Issue 18, 15 September 2026.
ABSTRACT Clonal hematopoiesis, particularly clonal hematopoiesis of indeterminate potential and clonal cytopenia of undetermined significance, is an age‐related premalignant condition characterized by the expansion of hematopoietic clones carrying somatic mutations.
Kelly S. Chien, Guillermo Garcia‐Manero   +1 more
wiley   +1 more source

Using Structural Biology to Characterize the Schizosaccharomyces pombe Spliceosome

, 2015
The spliceosome is a dynamic macromolecular machine composed of five different small nuclear ribonucleoproteins (snRNPs), the Nineteen Complex (NTC), RNA helicases, and other proteins that catalyze the removal of introns from pre-mRNA.
Collier, Scott Edward
core  

Integrative Transcriptomic Profiling Delineates LTBP4‐Driven Fibroblast Reprogramming Across the Ossification Continuum of the Ligamentum Flavum

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
This study delineates the dynamic transcriptomic landscape of OLF across normal, immature, and mature stages via RNA‐seq. LTBP4 shows progressive downregulation and is validated in external datasets. Single‐cell and spatial transcriptomics identify fibroblasts as the cellular source.
Xiao Zhang, Tengyao Niu, Yulong Zhao, Zhenguo Liu, Wenbo Gu, Donghui Cao, Yanrong Tian, Haifeng Yuan   +7 more
wiley   +1 more source

The Spliceosome [PDF]

Molecular Cell, 2002
openaire   +1 more source

U12-type introns and the minor spliceosome in dog

, 2015
Removal of introns, the non-coding sequences, from the mRNA is essential step of all eukaryotic gene expression. U12-type introns are a minor subgroup of introns that are extremely rare, but present in most eukaryotes.
Hallman, Merrit
core  

Decoding Spliceosome Dynamics through Computation and Experiment

RNA splicing is orchestrated by a complex and exceptionally dynamic RNA–protein machine, called the spliceosome. Stepwise, large-scale structural and compositional remodeling of the spliceosome enables splicing and ensures its fidelity.
Aupic J., Pokorna P., Magistrato A., Fica S. M.   +3 more
core   +1 more source

Splicing as an integrative layer linking cell cycle regulation, epigenetic dynamics, and environmental responses in plants. [PDF]

Front Plant Sci
Olimpio GV, de Araújo-Lopes BG, Gigier MO, Hemerly AS.   +3 more
europepmc   +1 more source

Spliceosome assembly

, 2011
Pre-mRNA splicing is a process in which introns are removed from eukaryotic transcripts and exons are ligated together. Splicing is catalyzed by spliceosome, a large ribonucleoprotein complex composed of five small nuclear RNAs and more than 100 ...
Hausnerová, Viola
core