Results 151 to 160 of about 34,718 (253)
Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.N‐acetyltransferase 10 (NAT10) catalyses N4‐acetylcytidine (ac4C) modification of PML pre‐mRNA, shifting splicing from the senescence‐promoting PML‐FL to the senescence‐inhibiting PML‐S isoform via SRSF1. This rejuvenates adipose‐derived stem cells (ADSCs) by reducing senescence markers and senescence‐associated secretory phenotype (SASP), thereby ...
Wuhan Wei +9 more
wiley +1 more source
The Spliceosome: The Ultimate RNA Chaperone and Sculptor
, 2016 The spliceosome, one of the most complex machineries of eukaryotic cells, removes intronic sequences from primary transcripts to generate functional messenger and long noncoding RNAs (lncRNA).
Panagiotis Papasaikas (813555)
core +1 more source
The Journal of Pathology, Volume 269, Issue 2, Page 222-231, June 2026.Abstract MYO7A is a causal gene, underlying Usher syndrome type 1B (USH1B) and both autosomal recessive (DFNB2) and dominant (DFNA11) non‐syndromic hearing loss. Despite the large number of reported MYO7A variants (over 2,200), variants located in an extended splice region remain difficult to interpret and are often classified as variants of uncertain ...
Tao Shi +5 more
wiley +1 more source
Using Structural Biology to Characterize the Schizosaccharomyces pombe Spliceosome
, 2015 The spliceosome is a dynamic macromolecular machine composed of five different small nuclear ribonucleoproteins (snRNPs), the Nineteen Complex (NTC), RNA helicases, and other proteins that catalyze the removal of introns from pre-mRNA.
Collier, Scott Edward
core
Structural Analysis of Catalytic and Post-catalytic Spliceosome Complexes [PDF]
, 2012 Pre-mRNA splicing is an essential step in eukaryotic gene expression. Splicing is catalyzed by the spliceosome, a large and highly dynamic macromolecular machine in the cell. Errors in splicing have been linked to many diseases, including cancer.
Ilagan, Janine
core
, 2018 Genomic analyses of cancer have identified recurrent point mutations in the RNA splicing factor-encoding genes SF3B1, U2AF1, and SRSF2 that confer an alteration of function(1-6).
Rachel Darman +71 more
core +1 more source
Sketching microprotein portraits
Protein Science, Volume 35, Issue 6, June 2026.Abstract The illustrations of intricate molecular machineries inside cells created by David Goodsell continue to inspire the scientific community. Here, we aim to extend his artworks to include microproteins, a newly recognized class of small proteins with less than 100 amino acids, encoded by small open reading frames.
Gabriel Diaz +6 more
wiley +1 more source
Editorial: Therapeutic targeting of splicing variants in cancer
Frontiers in Pharmacology, 2023 Pouya Sarvari +6 more
doaj +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto +7 more
wiley +1 more source