Results 151 to 160 of about 37,352 (250)
Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism
, 1994 Splicing of mRNA precursors (pre-mRNA) is preceded by assembly of the pre-mRNA with small nuclear ribonucleoprotein particles (snRNPs) and protein factors to form a spliceosome.
Mermoud, Jacqueline E. +2 more
core +2 more sources
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.● Monocyte dysfunction persisted across pulmonary embolism (PE) post‐diagnosis time points. ● ANNEXIN signalling was altered in CD16+ and CD16‐ monocytes. ● CD16+/CD16‐ monocyte communication tracked PE‐associated immune‐state changes. ● S100A8/A9 and FTH1/FTL may be candidate monocyte‐related genes in PE.
Tang Luojia +9 more
wiley +1 more source
HemaSphere, Volume 10, Issue 10, October 2026.Abstract Characterization of the presence and evolution of clonal hematopoiesis (CH) in patients with unexplained cytopenias is fundamental to risk‐stratifying patients and optimizing clinical surveillance for malignant progression. We investigated the mutational spectrum and clonal metrics in a cohort of 256 patients with chronic idiopathic ...
Grigorios Tsaknakis +11 more
wiley +1 more source
Relating transcriptomics to protein abundance reveals self‐driven versus interactor‐driven proteins
Protein Science, Volume 35, Issue 10, October 2026.Abstract Statistically modeling the interdependence between transcriptomics and protein abundances remains a persistent challenge in bioinformatics research. Transcriptomic data and proteomic abundances typically display a moderate Pearson's correlation of about 0.5, while in tumor conditions, the correlation may decrease to a much weaker correlation ...
Loulwah Arnaout +2 more
wiley +1 more source
Splicing Factor Mutations in Clonal Hematopoiesis and Progression to Myeloid Neoplasms
Cancer Science, Volume 117, Issue 10, Page 2609-2618, October 2026.Splicing factor (SF)‐mutant CH is characterized by relatively late emergence and accelerated clonal expansion in older individuals. This review summarizes its clonal dynamics, disease‐associated consequences of SF mutations in myeloid neoplasms, and candidate mechanisms that may contribute to age‐dependent selection.
Yang Lyu, Yutong Zhang, Ayana Kon
wiley +1 more source
Pre-spliceosome assembly in Saccharomyces pombe
, 2005 Pre-mRNA splicing is a key event in the regulation of gene expression. The remarkable precision of splicing is at least partially built into the mechanism of pre-spliceosome formation, which occurs during the early stage of spliceosome assembly and ...
Huang, Tao
core
Probing the genomic and proteomic basis of encystment in Oxytricha granulifera
mSystemsProtozoan encystment constitutes a pivotal survival strategy against environmental stressors; however, the molecular architecture governing this transition remains enigmatic, owing to limited genomic resources and a scarcity of integrated multi-omics ...
Miaomiao Wang +7 more
doaj +1 more source
Clonal Hematopoiesis and CAR T Cell Therapy: From Biological Crosstalk to Clinical Implications
International Journal of Laboratory Hematology, Volume 48, Issue 5, Page 961-971, October 2026.ABSTRACT Clonal hematopoiesis (CH) is increasingly recognized as a significant biological phenomenon in aging and cancer, marked by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations in genes associated with myeloid neoplasms.
Wei Du +4 more
wiley +1 more source