Results 131 to 140 of about 34,718 (253)
reservedA crucial stage in the expression of eukaryotic genes is the RNA splicing, in which the exons are combined to generate mature RNA products (such as protein-coding mRNAs or long non-coding RNAs (lnc-RNAs)) whereas the introns are removed from the ...
RACHELLO, FRANCESCA
core
Bimolecular Exon Ligation by the Human Spliceosome
, 1997 Intron excision is an essential step in eukaryotic gene expression, but the molecular mechanisms by which the spliceosome accurately identifies splice sites in nuclear precursors to messenger RNAs (pre-mRNAs) are not well understood.
Melissa J. Moore, Karin Anderson
core +1 more source
International Journal of Cancer, Volume 159, Issue 2, Page 302-319, 15 July 2026.Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon +5 more
wiley +1 more source
Splice Site Recognition During Early Spliceosome Assembly [PDF]
, 2019 Protein coding sequences in most eukaryotic pre-messenger RNAs (pre-mRNA) are interrupted by intervening sequences called introns, while the protein coding sequences are termed exons.
Lumba, Charles Leonard Mallari
core
International Journal of Cancer, Volume 159, Issue 2, Page 501-515, 15 July 2026.What's new? Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor survival and variable response to perioperative chemotherapy. Although histopathological features correlate with outcomes, the relationship specifically between adherens junction (AJ) protein expression and treatment response in EAC remains uncertain.
Bastian Grothey +8 more
wiley +1 more source
Structures of aberrant spliceosome intermediates on their way to disassembly [PDF]
Intron removal during pre-mRNA splicing is of extraordinary complexity and its disruption causes a vast number of genetic diseases in humans. While key steps of the canonical spliceosome cycle have been revealed by combined structure–function analyses ...
Horvath, A. +19 more
core +1 more source
Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics
American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan +10 more
wiley +1 more source
A Novel N‐Terminal PRPF6 Variant in Autosomal Dominant Retinitis Pigmentosa
Clinical Case ReportsThis report identifies the first N‐terminal PRPF6 variant (c.514C>T) as a cause of autosomal dominant Retinitis Pigmentosa. This novel variant is associated with progressive peripheral vision loss but notably preserved central visual acuity, suggesting a
Na Li, Yalong Dang
doaj +1 more source
Exploring the Impact of RNU4‐2 Defects on Neurodevelopmental Disorders in a Korean Population
Clinical Genetics, Volume 110, Issue 1, Page 90-95, July 2026.Among 15 450 Korean individuals, noncoding RNU4‐2 variants, primarily the recurrent de novo n.64_65insT, make up 0.72% of neurodevelopmental disorders. Modeling and RNA‐seq suggest U4/U6 disruption and abnormal 5′ splice‐site selection, supporting routine use of WGS analysis for reanalyzing unresolved cases. ABSTRACT Neurodevelopmental disorders (NDDs)
Juhyeon Hong +20 more
wiley +1 more source