Results 141 to 150 of about 37,352 (250)
Purification of spliceosome complexes associated with the U2 snRNP.
, 2016 (A) Detection by western blot of indicated splicing factors in nuclear extracts from HeLa S3 cells either WT (NE) or stably transduced with FV5-U2-B (NEB”). (B) Comparison of the kinetic and quality of spliceosome assembly on a radiolabeled AdML pre-mRNA
Michael P. Myers (31172) +5 more
core +1 more source
Molecular Oncology, Volume 20, Issue 10, Page 2466-2489, October 2026.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Animal Genetics, Volume 57, Issue 5, October 2026.ABSTRACT Environmental stressors in commercial poultry systems can negatively affect bird welfare, although individuals vary considerably in their responses. Neuroplasticity within the hippocampus, measured through the density of doublecortin‐positive (DCX+) neurons, provides a potential biomarker of stress experience in laying hens.
Lindsay Neuert +8 more
wiley +1 more source
Precursor RNA structural patterns at SF3B1 mutation sensitive cryptic 3’ splice sites
RNA BiologySF3B1 is a core component of the spliceosome involved in branch point recognition and 3’ splice site selection. The SF3B1 K700E mutation (lysine to glutamic acid) is common in myelodysplastic syndrome and other blood disorders.
Austin Herbert +5 more
doaj +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2350-2356, October 2026.ABSTRACT U2 small nuclear RNA auxiliary factor 2 (U2AF2) is an essential pre‐mRNA splicing factor involved in the early stages of pre‐mRNA splicing. To date, multiple individuals have been reported with predominantly heterozygous missense variants presenting intellectual disability, speech and motor delays, seizures, hypotonia, and thin or hypoplastic ...
Amanda Toledo +3 more
wiley +1 more source
Structures of aberrant spliceosome intermediates on their way to disassembly [PDF]
Intron removal during pre-mRNA splicing is of extraordinary complexity and its disruption causes a vast number of genetic diseases in humans. While key steps of the canonical spliceosome cycle have been revealed by combined structure–function analyses ...
Horvath, A. +19 more
core +1 more source
Reporting a Homozygous Case of Neurodevelopmental Disorder Associated With a Novel PRPF8 Variant
Molecular Genetics & Genomic MedicineBackground While recently identified heterozygous PRPF8 variants have been linked to various human diseases, their role in neurodevelopmental disorders (NDDs) remains ambiguous.
Mohammad Reza Mirinezhad +8 more
doaj +1 more source
Quantitation of Cirtuvivint (SM08502) in Human Plasma by LC–MS/MS
Biomedical Chromatography, Volume 40, Issue 10, October 2026.ABSTRACT CDC‐like kinases (CLK) and dual‐specificity tyrosine‐regulated kinases (DYRK) are protein kinases involved in various cellular functions, mRNA splicing, and DNA damage repair. CLK/DYRK kinases have been implicated in many disorders such as diabetes, neurodegenerative diseases, and cancer.
Julianne L. Holleran +10 more
wiley +1 more source
Bimolecular Exon Ligation by the Human Spliceosome
, 1997 Intron excision is an essential step in eukaryotic gene expression, but the molecular mechanisms by which the spliceosome accurately identifies splice sites in nuclear precursors to messenger RNAs (pre-mRNAs) are not well understood.
Melissa J. Moore, Karin Anderson
core +1 more source