Results 191 to 200 of about 58,017 (329)
The spliceosome: a flexible, reversible macromolecular machine
, 2012 Aaron A. Hoskins, Melissa J. Moore
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Journal of Cellular Physiology, Volume 241, Issue 1, January 2026.Abstract Preservation of the insulin‐sensitive glomerular podocyte is imperative for normal kidney function. The protein tyrosine phosphatases (PTPs), protein tyrosine phosphatase 1B (PTP1B), T‐cell protein tyrosine phosphatase (TCPTP), and Src homology phosphatase 2 (SHP2) are established regulators of insulin signaling in vivo and implicated in renal
Grace LeBleu +6 more
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Editorial: Therapeutic targeting of splicing variants in cancer
Frontiers in Pharmacology, 2023 Pouya Sarvari +6 more
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Cross‐Species Insights Into Gamma Herpesvirus Transcriptomes: Long‐Read and Multi‐Omics Perspectives
Journal of Medical Virology, Volume 98, Issue 1, January 2026.ABSTRACT Comparative transcriptome analyses of gamma herpesviruses have been revolutionized by long‐read sequencing and integrative multi‐omics approaches, enabling unprecedented resolution of viral gene expression. Cross‐species studies of Kaposi's sarcoma‐associated herpesvirus (KSHV), Epstein–Barr virus (EBV), and murine gamma herpesvirus 68 (MHV68)
Ritu Shekhar +4 more
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Two spliceosomes can form simultaneously and independently on synthetic double-intron messenger RNA precursors. [PDF]
, 1987 Gerhard Christofori +2 more
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Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways
MedComm, Volume 7, Issue 1, January 2026.Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. It restores synaptic function impaired by Aβ toxicity and improves cognitive performance in AD mouse models, APP/PS1 and 3xTg‐AD.
Yongeun Cho +18 more
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Advanced SciencetRNA‐derived fragments (tRFs), a novel class of small non‐coding RNAs cleaved from transfer RNAs, have been implicated in tumor regulation. In this study, the role of a specific tRF, HCETSR is investigated, which is significantly downregulated in ...
Tao Rui +13 more
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Obesity, Volume 34, Issue 1, Page 127-137, January 2026.ABSTRACT Objective Severe obesity poses a major public health concern due to its links with cardiometabolic complications and mortality. Visceral adipose tissue (VAT) plays a key role in these processes through distinct molecular features. This study aimed to characterize the VAT proteome of individuals with severe obesity and investigate its ...
Prince Dadson +10 more
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Yeast ortholog of the Drosophila crooked neck protein promotes spliceosome assembly through stable U4/U6.U5 snRNP addition [PDF]
, 1999 Seyung Chung +2 more
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