Results 31 to 40 of about 53,406 (189)
Structural basis for dual roles of Aar2p in U5 snRNP assembly [PDF]
, 2013 Yeast U5 small nuclear ribonucleoprotein particle (snRNP) is assembled via a cytoplasmic precursor that contains the U5-specific Prp8 protein but lacks the U5-specific Brr2 helicase.
Beggs, J.D. +8 more
core +1 more source
Spliceosome structure and function.
Cold Spring Harbor Perspectives in Biology, 2011 Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton ribonucleoprotein (RNP) complex comprised of five snRNPs and numerous proteins.
C. Will, R. Lührmann
semanticscholar +1 more source
Therapeutic potential of CDK11 in cancer
Clinical and Translational Medicine, 2023 Human cyclin‐dependent kinases (CDKs) direct the progression of the cell cycle and transcription. They are deregulated in tumours, and despite their involvement in the regulation of basic cellular processes, many CDKs are promising targets for cancer ...
Dalibor Blazek
doaj +1 more source
The spliceosome inhibitors isoginkgetin and pladienolide B induce ATF3-dependent cell death.
PLoS ONE, 2020 The spliceosome assembles on pre-mRNA in a stepwise manner through five successive pre-spliceosome complexes. The spliceosome functions to remove introns from pre-mRNAs to generate mature mRNAs that encode functional proteins.
Erin J Vanzyl +5 more
doaj +1 more source
SF3b4: A Versatile Player in Eukaryotic Cells
Frontiers in Cell and Developmental Biology, 2020 Spliceosomes are large protein-RNA complexes regulating pre-mRNA processing in eukaryotes. SF3b4 encodes a core subunit of the U2-type spliceosome, loss- or gain-of-function of which often associates with abnormal cell growth, leading to tumorigenesis ...
Feng Xiong, Sha Li, Sha Li
doaj +1 more source
Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types [PDF]
, 2018 Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer.
Alvaro, Domenico +12 more
core +1 more source
Mechanism of 5ʹ splice site transfer for human spliceosome activation
Science, 2019 Creation of the splicing catalytic center The catalytic center of the fully assembled, precatalytic pre–B spliceosome is not yet formed, even though all the pieces are present in this complex. Charenton et al.
C. Charenton, M. E. Wilkinson, K. Nagai
semanticscholar +1 more source
Transcriptome Analysis of the Cerebellum of Mice Fed a Manganese-Deficient Diet
Frontiers in Genetics, 2020 Manganese (Mn), primarily acquired through diet, is required for brain function and development. Epidemiological studies have found an association between both low and high levels of Mn and impaired neurodevelopment in children.
Young Ah Seo +4 more
doaj +1 more source
Pre-mRNA splicing-associated diseases and therapies
RNA Biology, 2023 Precursor mRNA (pre-mRNA) splicing is an essential step in human gene expression and is carried out by a large macromolecular machine called the spliceosome.
Sierra L. Love +3 more
doaj +1 more source
Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation
Science, 2020 Splicing machine shifts into gear Spliceosome activation involves extensive protein exchanges and RNA rearrangements that lead to the formation of a catalytically active U2/U6 RNA structure called Bact.
C. Townsend +9 more
semanticscholar +1 more source