Results 31 to 40 of about 58,017 (329)

Reciprocal intronic and exonic histone modification regions in humans. [PDF]

, 2010
While much attention has been focused on chromatin at promoters and exons, human genes are mostly composed of intronic sequences. Analyzing published surveys of nucleosomes and 41 chromatin marks in humans, we identified histone modifications ...
Guthrie, Christine, Huff, Jason T, Plocik, Alex M, Yamamoto, Keith R   +3 more
core   +5 more sources

Engineering Crystal Packing in RNA-Protein Complexes II: A Historical Perspective from the Structural Studies of the Spliceosome

Crystals, 2021
Cryo-electron microscopy has greatly advanced our understanding of how the spliceosome cycles through different conformational states to conduct the chemical reactions that remove introns from pre-mRNA transcripts.
Adelaine Kwun-Wai Leung, Yasushi Kondo, Daniel A. Pomeranz Krummel, Jade Li, Stephen R. Price, Anne-Marie M. van Roon   +5 more
doaj   +1 more source

Structural basis for dual roles of Aar2p in U5 snRNP assembly [PDF]

, 2013
Yeast U5 small nuclear ribonucleoprotein particle (snRNP) is assembled via a cytoplasmic precursor that contains the U5-specific Prp8 protein but lacks the U5-specific Brr2 helicase.
Beggs, J.D., Cristão, V.F., Heroven, A.C., Holton, N., Jovin, S.M., Lührmann, R., Santos, K.F., Wahl, M.C., Weber, G.   +8 more
core   +1 more source

SF3b4: A Versatile Player in Eukaryotic Cells

Frontiers in Cell and Developmental Biology, 2020
Spliceosomes are large protein-RNA complexes regulating pre-mRNA processing in eukaryotes. SF3b4 encodes a core subunit of the U2-type spliceosome, loss- or gain-of-function of which often associates with abnormal cell growth, leading to tumorigenesis ...
Feng Xiong, Sha Li, Sha Li
doaj   +1 more source

Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila

Biology Open, 2021
Retinitis pigmentosa (RP) is a clinically heterogeneous disease affecting 1.6 million people worldwide. The second-largest group of genes causing autosomal dominant RP in human encodes regulators of the splicing machinery.
Sarita Hebbar, Malte Lehmann, Sarah Behrens, Catrin Hälsig, Weihua Leng, Michaela Yuan, Sylke Winkler, Elisabeth Knust   +7 more
doaj   +1 more source

Rapidly evolving protointrons in Saccharomyces genomes revealed by a hungry spliceosome. [PDF]

, 2019
Introns are a prevalent feature of eukaryotic genomes, yet their origins and contributions to genome function and evolution remain mysterious. In budding yeast, repression of the highly transcribed intron-containing ribosomal protein genes (RPGs ...
Ares, Manuel, Donohue, John Paul, Igel, Haller, Katzman, Sol, Munding, Elizabeth M, Perriman, Rhonda J, Shelansky, Robert, Shiue, Lily, Talkish, Jason   +8 more
core   +1 more source

A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]

, 2014
There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Ahn, Aitken, Alexander, Alexander, Batsché, Bentley, Buratowski, Carrillo Oesterreich, Chapman, Chen, Cho, Cordin, Cramer, Damgaard, Das, David, de Almeida, Dönmez, Edgar, Egloff, Fong, Furger, Görnemann, Hirose, J. David Barrass, Jean D. Beggs, Ji, Kameoka, Keerthi T. Chathoth, Komarnitsky, Kornblihtt, Kornblihtt, Kosowski, Lacadie, Levine, Li, Lin, McCracken, McKay, Miller, Moore, Orphanides, Perriman, Perriman, Perriman, Perriman, Pleiss, Ruby, Schmidt, Schneider, Schroeder, Shao, Shaun Webb, Singh, Tardiff, Wahl, Wells, Witten, Xu, Xu, Yan, Zavanelli, Zhou   +62 more
core   +1 more source

Exploring Splicing-Energy Axis Associations to Diet and Longevity. [PDF]

Aging Cell
Caloric restriction improves mitochondrial function, while a low‐protein, high‐carbohydrate diet improves pre‐RNA splicing, as shown by Brandon et al. Despite employing distinct pathways, both dietary strategies enhance the energy‐splicing axis to increase longevity. ABSTRACT There is increasing evidence that nutrient composition, even without lowering
Donega S, Gorospe M, Ferrucci L.
europepmc   +2 more sources

SnapShot: Spliceosome Dynamics I

Cell, 2015
Spliceosomes are multi-megadalton RNA-protein molecular machines that carry out pre-mRNA splicing, that is, the removal of non-coding intervening sequences (introns) from eukaryotic pre-mRNAs and the ligation of neighboring coding regions (exons) to produce mature mRNA for protein biosynthesis on the ribosome.
Wahl, M., Lührmann, R.
openaire   +7 more sources

Alternative splicing: transcriptional regulatory network in agroforestry

Frontiers in Plant Science, 2023
Alternative splicing (AS) in plants plays a key role in regulating the expression of numerous transcripts from a single gene in a regulatory pathway. Variable concentrations of growth regulatory hormones and external stimuli trigger alternative splicing ...
Syed Sarfaraz Hussain, Syed Sarfaraz Hussain, Manzar Abbas, Sammar Abbas, Mingke Wei, Ahmed H. El-Sappah, Ahmed H. El-Sappah, Yuhan Sun, Yun Li, Arthur J. Ragauskas, Arthur J. Ragauskas, Arthur J. Ragauskas, Quanzi Li   +12 more
doaj   +1 more source