Results 41 to 50 of about 53,406 (189)
Coupling of spliceosome complexity to intron diversity
Current Biology, 2021 We determined that over 40 spliceosomal proteins are conserved between many fungal species and humans but were lost during the evolution of S. cerevisiae, an intron-poor yeast with unusually rigid splicing signals.
Jade Sales-Lee +8 more
semanticscholar +1 more source
Alternative pre-mRNA splicing as a mechanism for terminating Toll-like Receptor signaling
Frontiers in Immunology, 2022 While inflammation induced by Toll-like receptor (TLR) signaling is required to combat infection, persistent inflammation can damage host tissues and contribute to a myriad of acute and chronic inflammatory disorders.
Frank Fang Yao Lee +3 more
doaj +1 more source
RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts. [PDF]
, 2011 Over 50% of genes in Plasmodium falciparum, the deadliest human malaria parasite, contain predicted introns, yet experimental characterization of splicing in this organism remains incomplete.
DeRisi, Joseph L +2 more
core +3 more sources
Myeloid neoplasms with isolated isochromosome 17q: a yet to be defined entity
Mediterranean Journal of Hematology and Infectious Diseases, 2017 It has been suggested that myeloid neoplasms with isolated isochromosome 17q[MN i(17q)] comprise a distinct entity with poor prognosis. However, literature reports show a considerable clinical and molecular heterogeneity.
Eleftheria Lamprianidou +9 more
doaj +1 more source
Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome.
Cold Spring Harbor Perspectives in Biology, 2019 SUMMARYPrecursor messenger RNA (pre-mRNA) splicing is executed by the spliceosome. In the past 3 years, cryoelectron microscopy (cryo-EM) structures have been elucidated for a majority of the yeast spliceosomal complexes and for a few human spliceosomes.
Chuangye Yan, R. Wan, Yigong Shi
semanticscholar +1 more source
Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]
, 2019 Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D. +3 more
core +1 more source
Structure of the human activated spliceosome in three conformational states
Cell Research, 2018 During each cycle of pre-mRNA splicing, the pre-catalytic spliceosome (B complex) is converted into the activated spliceosome (Bact complex), which has a well-formed active site but cannot proceed to the branching reaction.
Xiaofeng Zhang +5 more
semanticscholar +1 more source
Rapidly evolving protointrons in Saccharomyces genomes revealed by a hungry spliceosome. [PDF]
, 2019 Introns are a prevalent feature of eukaryotic genomes, yet their origins and contributions to genome function and evolution remain mysterious. In budding yeast, repression of the highly transcribed intron-containing ribosomal protein genes (RPGs ...
Ares, Manuel +8 more
core +1 more source
PLoS ONE, 2018 The spliceosome is a large ribonucleoprotein complex that catalyzes the removal of introns from RNA polymerase II-transcribed RNAs. Spliceosome assembly occurs in a stepwise manner through specific intermediates referred to as pre-spliceosome complexes E,
Erin J Vanzyl +4 more
doaj +1 more source
Journal of Developmental Biology, 2022 Mandibulofacial dysostosis (MFD) is a human congenital disorder characterized by hypoplastic neural-crest-derived craniofacial bones often associated with outer and middle ear defects.
Byung-Yong Park +4 more
doaj +1 more source