Results 91 to 100 of about 10,182 (283)
Molecular Genetics & Genomic Medicine, 2021 Objective PE is a pregnancy‐specific syndrome that affects 3%–5% of pregnant women. It often presents as new‐onset hypertension and proteinuria during the third trimester.
Tao Zhang +11 more
doaj +1 more source
Seminars in Cell & Developmental Biology, 2018 The U12-dependent (minor) spliceosome excises a rare group of introns that are characterized by a highly conserved 5' splice site and branch point sequence. Several new congenital or somatic diseases have recently been associated with mutations in components of the minor spliceosome.
Maureen V. Akinyi +3 more
openaire +3 more sources
An Atomic Structure of the Human Spliceosome [PDF]
Cell, 2017 Mechanistic understanding of pre-mRNA splicing requires detailed structural information on various states of the spliceosome. Here we report the cryo electron microscopy (cryo-EM) structure of the human spliceosome just before exon ligation (the C∗ complex) at an average resolution of 3.76 Å.
Lorenzo I. Finci +5 more
openaire +3 more sources
Molecular Nutrition &Food Research, EarlyView.Excessive intake of saturated fats during pregnancy is associated with DNA hypomethylation in placental and cord blood samples from women affected with gestational diabetes mellitus (GDM), impacting, in particular, the cord blood promoter of ZFP57, a key regulator of early embryonic epigenetic programming.
Fatima Ahmad +13 more
wiley +1 more source
Molecular Nutrition &Food Research, EarlyView.In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang +7 more
wiley +1 more source
A stochastic view of spliceosome assembly and recycling in the nucleus. [PDF]
PLoS Computational Biology, 2007 How splicing factors are recruited to nascent transcripts in the nucleus in order to assemble spliceosomes on newly synthesised pre-mRNAs is unknown.
José Rino +5 more
doaj +1 more source
Universal power law behaviors in genomic sequences and evolutionary models
, 2007 We study the length distribution of a particular class of DNA sequences known as 5'UTR exons. These exons belong to the messanger RNA of protein coding genes, but they are not coding (they are located upstream of the coding portion of the mRNA) and are ...
Loredana Martignetti +2 more
core +1 more source
Identification of a novel splice variant of the haloacid dehalogenase: PHOSPHO1 [PDF]
, 2008 PHOSPHO1, a new member of the haloacid dehalogenase superfamily, has recently been implicated in the mineralization process in both osteoblasts and chondrocytes.
Farquharson, Colin +2 more
core +1 more source
Molecular Nutrition &Food Research, EarlyView.Over half of patients with colorectal cancer experience severe chemotherapy‐induced side effects. The B‐vitamin folate may play a role in these side effects, potentially by altering DNA methylation, a mechanism of gene regulation. Our comprehensive literature search identified studies investigating DNA methylation associated with folate status/intake ...
Nienke R. K. Zwart +3 more
wiley +1 more source
New Plant Protection, EarlyView.Applying population genomics, this study revealed that Pst exhibits slower linkage disequilibrium decay compared to rust fungi with known sexual reproduction, identified extensive hard and soft sweeps linked to Pst adaptation, and demonstrated that crop domestication and breeding programs have significantly influenced pathogen population sizes ...
Yun Xing +14 more
wiley +1 more source