Results 101 to 110 of about 5,818 (202)
MITF Regulates CFTR Expression to Participate in Myocardial Ischemia–Reperfusion Injury
The Journal of Gene Medicine, Volume 28, Issue 8, August 2026.MITF regulates CFTR expression in MIRI, and disruption of the MITF‐CFTR axis is associated with aggravated injury in cellular and animal models. Restoring CFTR partially mitigates MITF deficiency‐related damage. These findings support the involvement of MITF‐CFTR regulation in MIRI and provide a basis for further mechanistic investigation.
Baoxin Tang +4 more
wiley +1 more source
MedComm, Volume 7, Issue 8, August 2026.The study found that SARS‐CoV‐2 Omicron infection causes region‐specific inflammatory, immune, synaptic, and signaling disorders in the brain, and the predicted kinases and differentially expressed proteins may serve as potential targets for COVID‐19‐related drug discovery.
Qiaochu Wang +8 more
wiley +1 more source
Genetic analysis of primary lung interdigitating dendritic cell sarcomas
The Journal of Pathology, Volume 269, Issue 4-5, Page 387-398, August 2026.Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov +6 more
wiley +1 more source
FASEB BioAdvances, Volume 8, Issue 8, August 2026.Workflow for BICC1 interactome characterization in HEK293T cells. Cells expressing FLAG‐tagged BICC1 (full‐length or ΔSAM) were subjected to co‐immunoprecipitation under RNA‐preserved (−) or RNase‐treated (+) conditions (1). Interacting proteins were identified by LC–MS/MS (2) and analyzed through protein–protein interaction networks and functional ...
Heloísa Monteiro do Amaral‐Prado +7 more
wiley +1 more source
MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy
Cancer Science, Volume 117, Issue 8, Page 2085-2097, August 2026.MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley +1 more source
Liver International, Volume 46, Issue 8, August 2026.ABSTRACT Background and Aims Prognostic biomarkers that link disease progression and/or responses to therapeutic interventions in patients with primary biliary cholangitis (PBC) remain undefined. In this study, we used a machine learning (ML) approach with whole‐blood transcriptomic data to predict clinical outcomes in response to obeticholic acid (OCA)
Hussain Syed +10 more
wiley +1 more source
Plant, Cell &Environment, Volume 49, Issue 8, Page 6169-6187, August 2026.ABSTRACT Improving photosynthesis is proposed as a means of enhancing crop productivity. To assess whether simultaneous increases in light use‐efficiency and carbon assimilation are additive, we investigated the impact of elevated CO2 on the performance of a transgenic soybean line engineered for faster relaxation of photoprotection by overexpression ...
Dilkaran Singh +6 more
wiley +1 more source
Plant Biology, Volume 28, Issue 5, Page 1686-1697, August 2026.We generated a compound by chemical modification that can efficiently rescue growth without decreasing the immune response of the chs3‐2D autoimmune mutants, thus chemically uncoupling its growth–defence trade‐off. Abstract Plant development in many species including Arabidopsis relies on the accurate balance between growth and defence.
M. Keijzer +5 more
wiley +1 more source