Results 101 to 110 of about 6,735 (249)
Isolation and Accumulation of Spliceosomal Assembly Intermediates
, 2014 Isolating spliceosomes at a specific assembly stage requires a means to stall or enrich for one of the intermediate splicing complexes. We describe strategies to arrest spliceosomes at different points of complex formation and provide a detailed protocol
Janine O. Ilagan +5 more
core +1 more source
Distinct clinical and genetic characteristics of myelodysplastic syndrome in younger patients
British Journal of Haematology, EarlyView.Summary Myelodysplastic neoplasms (formerly myelodysplastic syndromes, MDS) are heterogeneous clonal haematological malignancies that primarily affect the elderly, though a notable proportion of patients are diagnosed at younger ages. We retrospectively analysed 1437 patients diagnosed or treated at Asan Medical Center between 1989 and 2022, comparing ...
Hyunkyung Park +15 more
wiley +1 more source
, 2015 (A) The RNA extracted from each gradient fraction was fractionated by denaturing PAGE and the 32P-containing species were detected by autoradiography. S-values were determined by comparison with the reference gradients containing 30S and 50S ribosomal ...
Olga V. Makarova (259232) +1 more
core +1 more source
British Journal of Pharmacology, EarlyView.Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff +3 more
wiley +1 more source
Splicing Factor Mutations in Clonal Hematopoiesis and Progression to Myeloid Neoplasms
Cancer Science, EarlyView.Splicing factor (SF)‐mutant CH is characterized by relatively late emergence and accelerated clonal expansion in older individuals. This review summarizes its clonal dynamics, disease‐associated consequences of SF mutations in myeloid neoplasms, and candidate mechanisms that may contribute to age‐dependent selection.
Yang Lyu, Yutong Zhang, Ayana Kon
wiley +1 more source
Frontiers in Molecular Neuroscience, 2017 While the cytoplasmic function of microRNA (miRNA) as post-transcriptional regulators of mRNA has been the subject of significant research effort, their activity in the nucleus is less well characterized.
Belinda J. Goldie +11 more
doaj +1 more source
Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8 [PDF]
, 2009 The U5 snRNA loop 1 aligns the 5' and 3' exons for ligation during the second step of pre-mRNA splicing. U5 is intimately associated with Prp8, which mediates pre-mRNA repositioning within the catalytic core of the spliceosome and interacts directly with
David Barrass, J. +5 more
core +1 more source
The DNA/RNA Helicase SETX Maintains R‐Loop Homeostasis to Promote Chemoresistance in Ovarian Cancer
Cancer Science, EarlyView.SETX maintains R‐loop homeostasis by resolving excessive R‐loops, thereby promoting tumor initiation and chemoresistance. Deficiency of SETX leads to accumulation of unsolved pathological R‐loops, resulting in irreparable DNA damage and ultimately leading to tumor suppression and chemosensitivity.
Zi‐Wei Hu +13 more
wiley +1 more source
Grass ResearchPerennial ryegrass (Lolium perenne) is one of the most important cool-season grasses used for forage and turf purposes. Heat stress is the primary abiotic factor threatening its pasture/turf persistence.
Wenxi Zha +4 more
doaj +1 more source
PLoS ONE, 2012 Human p29 is a putative component of spliceosomes, but its role in pre-mRNA is elusive. By siRNA knockdown and stable overexpression, we demonstrated that human p29 is involved in DNA damage response and Fanconi anemia pathway in cultured cells.
Chia-Hsin Chen +8 more
doaj +1 more source