Results 91 to 100 of about 5,818 (202)

Quantitation of Cirtuvivint (SM08502) in Human Plasma by LC–MS/MS

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT CDC‐like kinases (CLK) and dual‐specificity tyrosine‐regulated kinases (DYRK) are protein kinases involved in various cellular functions, mRNA splicing, and DNA damage repair. CLK/DYRK kinases have been implicated in many disorders such as diabetes, neurodegenerative diseases, and cancer.
Julianne L. Holleran, Joshua J. Deppas, Ye Feng, Michael J. Hochman, Evan C. Chen, Maximilian Stahl, Steven D. Gore, Timothy W. Synold, Jan H. Beumer, Raman Venkataramanan, Robert A. Parise   +10 more
wiley   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer

The Journal of Pathology, Volume 270, Issue 1, Page 55-68, September 2026.
Abstract Recently, we suggested the combination of chemotherapy and P2RX4 inhibition as a promising novel therapeutic approach for P2RX4‐expressing epithelial tumors to prevent paracrine resistance. Here, we aimed to assess whether determining P2RX4 expression status in colorectal and pancreatic cancer patients would allow stratification of potentially
Christoph Steup, Julian Dosch, Christopher Dietz‐Fricke, Sara Khosraviseftejani, Esther Engel, Adalbert F de Valk, Dominic Menger, Patrick Welker, Peter J Wild, Kilian B Kennel, Maja Kantlehner, Paul K Ziegler, Florian R Greten   +12 more
wiley   +1 more source

Mycorrhiza‐induced resistance against Botrytis cinerea in tomato operates through the systemin signalling cascade

New Phytologist, Volume 251, Issue 6, Page 3522-3539, September 2026.
Prosystemin expression in mycorrhizal plants and comparative analysis of prosystemin and mycorrhiza in induced resistance. Summary Arbuscular mycorrhizal fungi enhance plant resistance against necrotrophic fungi by priming jasmonic acid‐dependent defences.
Julia Pastor‐Fernandez, María Manresa‐Grao, Paloma Sánchez‐Bel, Silvia Andrés‐Moreno, María J. Pozo, Victoria Pastor, Víctor Flors   +6 more
wiley   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Molecular and Genetic Landscape of Intravenous Leiomyomatosis: A Narrative Review

Cancer Innovation, Volume 5, Issue 4, August 2026.
Intravenous leiomyomatosis is a rare uterine benign tumor characterized by intravascular growth, quasi‑malignant behavior, and a high recurrence rate. This review summarizes its molecular and genetic research progress, compares it with similar tumors, discusses unsolved issues and prospects, contributing to its pathogenesis, diagnosis, and future ...
Lei Li, Jing Zhou, Jia Kang, Xudong Liu, Ran Chen, Meng Yuan, Zhuo Yu, Jinhui Wang   +7 more
wiley   +1 more source

Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins

The EMBO Journal
The B complex is a key intermediate stage of spliceosome assembly. To improve the structural resolution of monomeric, human spliceosomal B (hB) complexes and thereby generate a more comprehensive hB molecular model, we determined the cryo-EM structure of
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Henning Urlaub, Holger Stark, Reinhard Lührmann   +6 more
doaj   +1 more source

Epigenetic and Brain Structure Covariation Patterns in Typical and Atypical Development

Human Brain Mapping, Volume 47, Issue 11, 01 August 2026.
We present a map linking DNA methylation to brain structure in childhood. Genes in which methylation was linked to brain anatomy are highly enriched for those implicated in psychiatric and neurodevelopmental disorders, highlighting potential epigenetic targets for understanding both typical and atypical brain development.
Valentine Chirokoff, Jo Wrigglesworth, Peter Daniel Fransquet, Yen Ting Wong, Jeffrey M. Craig, Tim J. Silk   +5 more
wiley   +1 more source

Transcriptomic Convergence in Autism Spectrum Disorder: Synaptic, Immune‐Glial and RNA‐Regulatory Axes in the Human Cerebral Cortex

International Journal of Developmental Neuroscience, Volume 86, Issue 5, August 2026.
Across 43 human post‐mortem cortical transcriptomic studies, ASD shows recurrent but non‐uniform convergence on reduced synaptic‐neuronal signalling, increased immune‐glial activity and RNA‐regulatory dysregulation. Metabolic and mitochondrial changes are less consistently supported and appear more conditional within the current cortical evidence base.
Ruslan Kurmashev
wiley   +1 more source