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Mechanisms of Spliceosomal Assembly
2014Pre-mRNA splicing is a key step for generating mature protein-coding mRNA. An RNA-protein complex known as the spliceosome carries out the chemistry of pre-mRNA splicing. However, several pre-spliceosomal intermediates are assembled on the pre-mRNA before the formation of the catalytically activated spliceosome.
Ni-Ting, Chiou, Kristen W, Lynch
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Spliceosome Assembly and Composition
2007Cells control alternative splicing by modulating assembly of the pre-mRNA splicing machinery at competing splice sites. Therefore, a working knowledge of spliceosome assembly is essential for understanding how alternative splice site choices are achieved.
Arianne J, Matlin, Melissa J, Moore
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Spliceosomal Proteins in Plants
2008The spliceosome is a large nuclear structure consisting of dynamically interacting RNAs and proteins. This chapter briefly reviews some of the known components and their interactions. Large-scale proteomics and gene expression studies may be required to unravel the many intricate mechanisms involved in splice site recognition and selection.
Y, Ru, B-B, Wang, V, Brendel
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A model for DHX15 mediated disassembly of A-complex spliceosomes
Rna, 2022Melissa Jurica, Hannah M Maul-Newby
exaly