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Science, 1991
In cell extracts, the snRNAs exist associated with proteins as small nuclear ribonucleoproteins (snRNPs, pronounced «snurps»). In an in vitro splicing reaction, the snRNPs, other essential protein factors, and the pre-mRNA form a macromolecular complex known as a spliceosome.
Joseph Gall
exaly +3 more sources
In cell extracts, the snRNAs exist associated with proteins as small nuclear ribonucleoproteins (snRNPs, pronounced «snurps»). In an in vitro splicing reaction, the snRNPs, other essential protein factors, and the pre-mRNA form a macromolecular complex known as a spliceosome.
Joseph Gall
exaly +3 more sources
Architecture of the Spliceosome
Biochemistry, 2012Precursor-mRNA splicing is catalyzed by an extraordinarily large and highly dynamic macromolecular assemblage termed the spliceosome. Detailed biochemical and structural study of the spliceosome presents a formidable challenge, but there has recently been significant progress made on this front highlighted by the crystal structure of a 10-subunit human
Clarisse, van der Feltz +3 more
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BioEssays, 1993
AbstractThe spliceosome is a large RNA‐protein complex that catalyses the removal of introns from nuclear pre‐mRNA. A wide range of biochemical and genetical studies shows that the spliceosome comprises three major RNA‐protein subunits, the U1, U2 and [U4/U6.U5] small nuclear ribonucleoprotein particles (snRNPs), and an additional group of non‐snRNP ...
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AbstractThe spliceosome is a large RNA‐protein complex that catalyses the removal of introns from nuclear pre‐mRNA. A wide range of biochemical and genetical studies shows that the spliceosome comprises three major RNA‐protein subunits, the U1, U2 and [U4/U6.U5] small nuclear ribonucleoprotein particles (snRNPs), and an additional group of non‐snRNP ...
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A glimpse into the spliceosome
Current Biology, 1993The removal of introns from mRNA precursors (premRNA) is a complex process that takes place in the nucleus in a multi-component structure known as the spliceosome. The spliceosome is comparable in size and complexity to the ribosome and is mainly comprised of four RNA-protein complexes, the Ul, U2, U4/U6 and U5 small nuclear ribonucleoprotein particles
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Science, 1996
In this issue of Science , Tarn and Steitz ( p. 1824 ) report the identification of two new RNAs that reside in the special spliceosome that acts on the rare AT-AC class of introns. In his Perspective, Nilsen describes why the now complete description of the RNA components of this spliceosome
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In this issue of Science , Tarn and Steitz ( p. 1824 ) report the identification of two new RNAs that reside in the special spliceosome that acts on the rare AT-AC class of introns. In his Perspective, Nilsen describes why the now complete description of the RNA components of this spliceosome
openaire +2 more sources
RNA Splicing by the Spliceosome
Annual Review of Biochemistry, 2020The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades of biochemistry and genetics combined with recent structural studies of the spliceosome have produced a detailed view of the mechanism of splicing. In this review, we aim to make this mechanism understandable and provide several videos of the spliceosome in action to ...
Wilkinson, Max E. +2 more
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The evolution of spliceosomal introns
Current Opinion in Genetics & Development, 2002Although the widespread proliferation of introns in eukaryotic protein-coding genes remains one of the most poorly understood aspects of genomic architecture, major advances have emerged recently from large-scale genome sequencing projects and functional analyses of mRNA-processing events.
Michael, Lynch, Aaron O, Richardson
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