Results 141 to 150 of about 6,735 (249)

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer

The Journal of Pathology, Volume 270, Issue 1, Page 55-68, September 2026.
Abstract Recently, we suggested the combination of chemotherapy and P2RX4 inhibition as a promising novel therapeutic approach for P2RX4‐expressing epithelial tumors to prevent paracrine resistance. Here, we aimed to assess whether determining P2RX4 expression status in colorectal and pancreatic cancer patients would allow stratification of potentially
Christoph Steup, Julian Dosch, Christopher Dietz‐Fricke, Sara Khosraviseftejani, Esther Engel, Adalbert F de Valk, Dominic Menger, Patrick Welker, Peter J Wild, Kilian B Kennel, Maja Kantlehner, Paul K Ziegler, Florian R Greten   +12 more
wiley   +1 more source

Pre-spliceosome assembly in Saccharomyces pombe

, 2005
Pre-mRNA splicing is a key event in the regulation of gene expression. The remarkable precision of splicing is at least partially built into the mechanism of pre-spliceosome formation, which occurs during the early stage of spliceosome assembly and ...
Huang, Tao
core  

Prenatal Phenotypic Features of Five Fetal Cases With RNU4ATAC‐Associated Microcephalic Osteodysplastic Primordial Dwarfism Type I

Prenatal Diagnosis, Volume 46, Issue 10, Page 1648-1654, September 2026.
ABSTRACT Objective To present the prenatal sonographic features, genomic findings, and pregnancy outcomes of fetuses with biallelic pathogenic RNU4ATAC variants linked to microcephalic osteodysplastic primordial dwarfism type I (MOPD1). Methods This retrospective case series includes five prenatal cases with MOPD1.
Alexandra Liebmann, Tanja Richter, Nevena Krstić, Markus Hoopmann, Karl Oliver Kagan, Lena‐Sophie Menig‐Benzig, Simone Olivieri, Olaf Riess, Andreas Dufke   +8 more
wiley   +1 more source

Zea mays Drought‐Overly Sensitive1/TUBA4 Is Wilty3, and Transcriptome Co‐Expression Analysis of Shoot Meristem Mutant Tissues Reveals Wilty2/TUB6:Wi3 Interactions Associated With Stem Vascular Bundle Development

Plant Direct, Volume 10, Issue 9, September 2026.
ABSTRACT Plant vasculature is essential for the transport of water, nutrients, and signaling molecules across organs, while also providing critical mechanical support for growth and development. Disruptions in vascular bundle formation can therefore lead to severe physiological and developmental defects.
Anuradha Dhingra, Indra Adhikari, Christopher D. Rock   +2 more
wiley   +1 more source

Update on Nuclear Speckles in Plants Localization and Dynamics of Nuclear Speckles in Plants 1

, 2020
The generation of mature mRNAs from most genes (about 80%-90%) in autotrophic eukaryotes requires the removal of noncoding sequences (introns) and splicing of the coding regions (exons; SPLICING REGULATORS pre-mRNAs splicing takes place ...

core  

A pangenome‐based approach reveals genes associated with polyploidy and apomixis in Eragrostis curvula

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Eragrostis curvula is a forage grass species in which multiple cytotypes coexist and shifts between sexual and apomictic reproduction are common. This study investigates genetic variation among these cytotypes in relation to ploidy levels and reproductive modes.
Giacomo Bongiorno, José Carballo, Juan Pablo Selva, Diego Zappacosta, Emidio Albertini, Viviana Echenique   +5 more
wiley   +1 more source

DHX15 affects AML1‐ETO9a splicing together with HNRNPL, RBM33 in AML1‐ETO‐positive acute myeloid leukaemia

British Journal of Haematology, Volume 209, Issue 3, Page 964-977, September 2026.
Moderate DHX15, HNRNPL and RBM33 expression drives predominant AML1‐ETO mRNA production, while elevated expression of them promotes generating more AE9a mRNA (Aspartic acid ‐ Glutamic acid ‐ Alanine ‐ Aspartic acid sequence)(messenger ribonucleic acid).
Qiao Liu, Xuechun Wang, Jiqiang Fan, Yi Zheng, Luya Ye, Wenhan Chang, Xianglei Chen, Yuanhua Cai, Xiaolin Lai, Yang Li, Lili Pan, Xiaofan Li, RenJang Lin, Shaoyuan Wang   +13 more
wiley   +1 more source

Multi‐omics analysis reveals insights into the differentiation between radiological subtypes of early lung adenocarcinoma

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Huiwen Miao, Ruiying Kong, Xiaobo Xu, Mimi Wang, Xiao Teng, Dingli Zhu, Wenyi Zhao, Sheng Cai, Jingqi Zhou, Xiayi Lv, Zhan Zhou   +10 more
wiley   +1 more source

circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer

Cancer Science, Volume 117, Issue 9, Page 2345-2356, September 2026.
circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang, Hui Wang, Yonghang Xu, Lingyun Geng, Yanqing Wang   +4 more
wiley   +1 more source