Results 131 to 140 of about 6,735 (249)
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.This study delineates the dynamic transcriptomic landscape of OLF across normal, immature, and mature stages via RNA‐seq. LTBP4 shows progressive downregulation and is validated in external datasets. Single‐cell and spatial transcriptomics identify fibroblasts as the cellular source.
Xiao Zhang +7 more
wiley +1 more source
Effect of RNase A and transcriptional inhibition on the intranuclear distribution of MUC1.
, 2013 (A) BeWo cells were fixed and permeabilized using methanol and then incubated with RNase A (100 µg/mL) for 2 h as described in Methods. The cells were then stained with antibodies against MUC1 (HMFG1 and B27.29), U2AF65, and spliceosomes as indicated ...
Priyadarsina Kumar (312156) +5 more
core +1 more source
Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy
Annals of Clinical and Translational Neurology, Volume 13, Issue 9, Page 1951-1955, September 2026.ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier +6 more
wiley +1 more source
Advanced Science, Volume 13, Issue 51, 14 September 2026.This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding +13 more
wiley +1 more source
Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing [PDF]
, 1989 Pre-mRNA splicing occurs in a macromolecular complex called the spliceosome. Efforts to isolate spliceosomes from in vitro splicing reactions have been hampered by the presence of endogenous complexes that copurify with de novo spliceosomes formed on ...
Conway, G. C. +3 more
core
Advanced Science, Volume 13, Issue 51, 14 September 2026.CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas +13 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Mature oocytes were subjected to cryopreservation followed by intracytoplasmic sperm injection (ICSI). Embryos at multiple developmental stages were collected, dissociated into single cells and processed for single‐cell library construction and bioinformatics analysis.
Yixin Ren +14 more
wiley +1 more source
MedComm, Volume 7, Issue 9, September 2026.This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng +9 more
wiley +1 more source