Results 151 to 160 of about 6,735 (249)

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, Volume 59, Issue 9, September 2026.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Assembly of exon junction complexes on spliceosomes begins before spliceosome activation. [PDF]

Nucleic Acids Res
Abshire ET, Maquat LE.
europepmc   +1 more source

DDX41 mutations establish a separate entity in acute myeloid leukemia with distinct survival outcomes

HemaSphere, Volume 10, Issue 9, September 2026.
Carolin Seeling, Maral Saadati, Daniela Späth, Michael Heuser, Felicitas Thol, Arnold Ganser, Elli Papaemmanuil, Lars Bullinger, Axel Benner, Hartmut Döhner, Konstanze Döhner   +10 more
wiley   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, Volume 293, Issue 17, Page 5149-5169, September 2026.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

Targeting the KIFC1‐SRSF3‐PKM Axis Suppresses Cervical Cancer Glycolysis and Enhances Radiosensitivity

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT Metabolic reprogramming towards enhanced glycolysis contributes to cervical cancer progression and radioresistance, but its upstream regulatory mechanisms remain poorly understood. Here, we investigated the role and underlying mechanisms of kinesin family member C1 (KIFC1) in glycolytic reprogramming and radiosensitivity in cervical cancer ...
Junxia Liu, Jiahao Li, Haiting Zhou, Wentao Ha, Xinyu Wu, Xiangdong Liu, Yizhi Jiang, Chen Gong, Yi Cheng, Qingxu Liu, Tengfei Chao, Huihua Xiong   +11 more
wiley   +1 more source

Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase. [PDF]

Nat Commun
Zhang Z, Kumar V, Panta S, Zhong J, Dybkov O, Dong H, Kastner B, Urlaub H, Stark H, Lührmann R.   +9 more
europepmc   +1 more source

Optimized TadA‐derived base editors efficiently manipulate mRNA splicing by A‐to‐G and C‐to‐K editing in potato

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3329-3339, September 2026.
Two optimized TadA‐derived base editors efficiently generate diverse splicing variants by targeting specific splice sites in potato. ABSTRACT Pre‐messenger RNA (pre‐mRNA) splicing is a critical mechanism for post‐transcriptional regulation in plants. Through alternative splicing, plants produce diverse transcriptomes and proteomes that finely regulate ...
Kaiyuan Chen, Yan Zhang, Jiuzhou Deng, Lumin Zhang, Huiying Zhou, Yaxin Duan, Enle Xiao, Guangtao Zhu, Chunzhi Zhang   +8 more
wiley   +1 more source

Investigation of spliceosome assembly and the cross-talk with miRNA biogenesis

Pre-mRNA splicing is a critical RNA processing event that occurs on the spliceosome, a large and dynamic protein-RNA complex comprising over 100 proteins.
Maruntel, I
core   +1 more source

The G-patch protein Cwf28 interacts with the RNA helicase Cdc28 in catalytically active spliceosomes in Schizosaccharomyces pombe. [PDF]

PLoS One
Karika LO, Cipakova I, Kretova M, Selicky T, Cmikova N, Nemcekova D, Kohutova L, Barath P, Cipak L.   +8 more
europepmc   +1 more source

Transcriptomic Landscape Reveals Immunity Related Trade‐Offs in an Invertebrate‐Fungal Host–Parasite System

Molecular Ecology, Volume 35, Issue 18, September 2026.
ABSTRACT Host–parasite interactions represent an evolutionary arms race, with parasites evolving strategies to exploit host resources, and hosts deploying mechanisms to resist or tolerate infection. Unlike vertebrates, which possess a sophisticated immune system, invertebrates rely entirely on innate immunity to combat pathogens.
Sofia Paraskevopoulou, Sabrina Gattis, Frida Ben‐Ami   +2 more
wiley   +1 more source