Results 211 to 220 of about 6,735 (249)
Stalled Spliceosomes Are a Signal for RNAi-Mediated Genome Defense [PDF]
Cell, 2013 SummaryUsing the yeast Cryptococcus neoformans, we describe a mechanism by which transposons are initially targeted for RNAi-mediated genome defense. We show that intron-containing mRNA precursors template siRNA synthesis.
John R Yates +2 more
exaly +3 more sources
Nucleic Acids Research, 2021 Vertebrate genomes contain major (>99.5%) and minor (
Joan Heath +2 more
exaly +2 more sources
Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2 [PDF]
Nucleic Acids Research, 2017 The DEAH-box NTPase Prp43 disassembles spliceosomes in co-operation with the cofactors Ntr1/Spp382 and Ntr2, forming the NTR complex. How Prp43 is regulated by its cofactors to discard selectively only intron-lariat spliceosomes (ILS) and defective ...
Ralf Ficner +2 more
exaly +2 more sources
Rearrangements within human spliceosomes captured after exon ligation [PDF]
Rna, 2013 In spliceosomes, dynamic RNA/RNA and RNA/protein interactions position the pre-mRNA substrate for the two chemical steps of splicing. Not all of these interactions have been characterized, in part because it has not been possible to arrest the complex at
Melissa Jurica +2 more
exaly +2 more sources
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Science, 1991
In cell extracts, the snRNAs exist associated with proteins as small nuclear ribonucleoproteins (snRNPs, pronounced «snurps»). In an in vitro splicing reaction, the snRNPs, other essential protein factors, and the pre-mRNA form a macromolecular complex known as a spliceosome.
Joseph Gall
exaly +3 more sources
In cell extracts, the snRNAs exist associated with proteins as small nuclear ribonucleoproteins (snRNPs, pronounced «snurps»). In an in vitro splicing reaction, the snRNPs, other essential protein factors, and the pre-mRNA form a macromolecular complex known as a spliceosome.
Joseph Gall
exaly +3 more sources
Architecture of the Spliceosome
Biochemistry, 2012Precursor-mRNA splicing is catalyzed by an extraordinarily large and highly dynamic macromolecular assemblage termed the spliceosome. Detailed biochemical and structural study of the spliceosome presents a formidable challenge, but there has recently been significant progress made on this front highlighted by the crystal structure of a 10-subunit human
Clarisse, van der Feltz +3 more
openaire +2 more sources
Cell Cycle, 2013 PDIP38 (polymerase delta interacting protein 38) was originally discovered as a protein that interacts with DNA polymerase δ and PCNA. PDIP38 is present in multiple intracellular locations and is a multifunctional protein that has been implicated in ...
Marietta Lee +2 more
exaly +2 more sources
BioEssays, 1993
AbstractThe spliceosome is a large RNA‐protein complex that catalyses the removal of introns from nuclear pre‐mRNA. A wide range of biochemical and genetical studies shows that the spliceosome comprises three major RNA‐protein subunits, the U1, U2 and [U4/U6.U5] small nuclear ribonucleoprotein particles (snRNPs), and an additional group of non‐snRNP ...
openaire +3 more sources
AbstractThe spliceosome is a large RNA‐protein complex that catalyses the removal of introns from nuclear pre‐mRNA. A wide range of biochemical and genetical studies shows that the spliceosome comprises three major RNA‐protein subunits, the U1, U2 and [U4/U6.U5] small nuclear ribonucleoprotein particles (snRNPs), and an additional group of non‐snRNP ...
openaire +3 more sources
Science, 1996
In this issue of Science , Tarn and Steitz ( p. 1824 ) report the identification of two new RNAs that reside in the special spliceosome that acts on the rare AT-AC class of introns. In his Perspective, Nilsen describes why the now complete description of the RNA components of this spliceosome
openaire +2 more sources
In this issue of Science , Tarn and Steitz ( p. 1824 ) report the identification of two new RNAs that reside in the special spliceosome that acts on the rare AT-AC class of introns. In his Perspective, Nilsen describes why the now complete description of the RNA components of this spliceosome
openaire +2 more sources
A glimpse into the spliceosome
Current Biology, 1993The removal of introns from mRNA precursors (premRNA) is a complex process that takes place in the nucleus in a multi-component structure known as the spliceosome. The spliceosome is comparable in size and complexity to the ribosome and is mainly comprised of four RNA-protein complexes, the Ul, U2, U4/U6 and U5 small nuclear ribonucleoprotein particles
openaire +3 more sources