Results 221 to 230 of about 6,735 (249)

RNA Splicing by the Spliceosome

Annual Review of Biochemistry, 2020
The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades of biochemistry and genetics combined with recent structural studies of the spliceosome have produced a detailed view of the mechanism of splicing. In this review, we aim to make this mechanism understandable and provide several videos of the spliceosome in action to ...
Wilkinson, Max E., Charenton, Clément, Nagai, Kiyoshi   +2 more
openaire   +2 more sources

The evolution of spliceosomal introns

Current Opinion in Genetics & Development, 2002
Although the widespread proliferation of introns in eukaryotic protein-coding genes remains one of the most poorly understood aspects of genomic architecture, major advances have emerged recently from large-scale genome sequencing projects and functional analyses of mRNA-processing events.
Michael, Lynch, Aaron O, Richardson
openaire   +2 more sources

Mechanisms of Spliceosomal Assembly

2014
Pre-mRNA splicing is a key step for generating mature protein-coding mRNA. An RNA-protein complex known as the spliceosome carries out the chemistry of pre-mRNA splicing. However, several pre-spliceosomal intermediates are assembled on the pre-mRNA before the formation of the catalytically activated spliceosome.
Ni-Ting, Chiou, Kristen W, Lynch
openaire   +2 more sources

Spliceosomal Proteins in Plants

2008
The spliceosome is a large nuclear structure consisting of dynamically interacting RNAs and proteins. This chapter briefly reviews some of the known components and their interactions. Large-scale proteomics and gene expression studies may be required to unravel the many intricate mechanisms involved in splice site recognition and selection.
Y, Ru, B-B, Wang, V, Brendel
openaire   +2 more sources

Spliceosome Assembly and Composition

2007
Cells control alternative splicing by modulating assembly of the pre-mRNA splicing machinery at competing splice sites. Therefore, a working knowledge of spliceosome assembly is essential for understanding how alternative splice site choices are achieved.
Arianne J, Matlin, Melissa J, Moore
openaire   +2 more sources

SPLICEOSOMAL snRNAs

Annual Review of Genetics, 1988
C, Guthrie, B, Patterson
openaire   +3 more sources

Identification of the TSSK4 Alternative Spliceosomes and Analysis of the Function of the TSSK4 Protein in Yak (Bos grunniens)

Animals, 2022
Pengjia Bao, Jie Pei, Xian Guo
exaly  

Spliceosomes

RCSB Protein Data Bank, 2020
openaire   +1 more source

A model for DHX15 mediated disassembly of A-complex spliceosomes

Rna, 2022
Melissa Jurica, Hannah M Maul-Newby
exaly  

Specific small nuclear RNAs are associated with yeast spliceosomes

Cell, 1986
Michael Rosbash
exaly