Results 1 to 10 of about 483,589 (358)

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

Nature, 2019
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex1–4. The large subunit of Pol II contains an intrinsically disordered C-terminal domain that is
Alessandra Dall'agnese, Ann Boija, Benjamin R Sabari   +2 more
exaly   +2 more sources

Predicting Splicing from Primary Sequence with Deep Learning

Cell, 2019
Kishore Jaganathan, Jeremy F Mcrae, Yang I Li   +2 more
exaly   +2 more sources

Alternative splicing as a regulator of development and tissue identity

Nature Reviews Molecular Cell Biology, 2017
Hannah J Wiedner
exaly   +2 more sources

Alternative‐splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics

Wiley Interdisciplinary Reviews RNA, 2018
Nathan K Leclair, Olga Anczuków
exaly   +2 more sources

RNA splicing factors as oncoproteins and tumour suppressors

Nature Reviews Cancer, 2016
Heidi Dvinge, Eunhee Kim, Omar Abdel-wahab   +2 more
exaly   +2 more sources

Altered splicing of ATG16‐L1 mediates acquired resistance to tyrosine kinase inhibitors of EGFR by blocking autophagy in non‐small cell lung cancer

Molecular Oncology, 2022
Despite the initial efficacy of using tyrosine kinase inhibitors of epidermal growth factor receptors (EGFR‐TKIs) for treating patients with non‐small cell lung cancer (NSCLC), resistance inevitably develops.
Anne‐Sophie Hatat, Clara Benoit‐Pilven, Amélie Pucciarelli, Florence deFraipont, Lucie Lamothe, Pascal Perron, Amandine Rey, Matteo Giaj Levra, Anne‐Claire Toffart, Didier Auboeuf, Beatrice Eymin, Sylvie Gazzeri   +11 more
doaj   +1 more source

Alternative splicing and cancer: a systematic review

Signal Transduction and Targeted Therapy, 2021
The abnormal regulation of alternative splicing is usually accompanied by the occurrence and development of tumors, which would produce multiple different isoforms and diversify protein expression. The aim of the present study was to conduct a systematic
Y. Zhang, Jinjun Qian, C. Gu, Ye Yang
semanticscholar   +1 more source

Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors

Nature Communications, 2021
Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition
Constantin Cretu, Patricia Gee, Xiang Liu, Anant Agrawal, Tuong-Vi Nguyen, Arun K. Ghosh, Andrew Cook, Melissa Jurica, Nicholas A. Larsen, Vladimir Pena   +9 more
doaj   +1 more source

Case Report: Identification and Functional Analysis of a Homozygous Synonymous Variant in the PLOD1 Gene in a Chinese Neonatal With the Ehlers–Danlos Syndrome

Frontiers in Pediatrics, 2022
BackgroundKyphoscoliotic Ehlers–Danlos syndrome (kEDS; OMIM225400) is a rare autosomal recessive genetic disease caused by variants in the PLOD1 gene. This research was conducted to verify the disease-causing gene in a Chinese neonatal family with the ...
Xiaodan Yan, Xiaodan Yan, Jianbo Shu, Jianbo Shu, Yanyan Nie, Ying Zhang, Ying Zhang, Ping Wang, Ping Wang, Weiwei Zhou, Weiwei Zhou, Xiaoyu Cui, Xiaoyu Cui, Yang Liu   +13 more
doaj   +1 more source

Identification of Alternative Polyadenylation in Cyanidioschyzon merolae Through Long-Read Sequencing of mRNA

Frontiers in Genetics, 2022
Alternative polyadenylation (APA) is widespread among metazoans and has been shown to have important impacts on mRNA stability and protein expression. Beyond a handful of well-studied organisms, however, its existence and consequences have not been well ...
Leonard Schärfen, Dagmar Zigackova, Kirsten A. Reimer, Martha R. Stark, Viktor A. Slat, Nancy J. Francoeur, Melissa L. Wells, Lecong Zhou, Perry J. Blackshear, Karla M. Neugebauer, Stephen D. Rader   +10 more
doaj   +1 more source