Results 1 to 10 of about 335,173 (238)
Molecular Oncology, 2022 Despite the initial efficacy of using tyrosine kinase inhibitors of epidermal growth factor receptors (EGFR‐TKIs) for treating patients with non‐small cell lung cancer (NSCLC), resistance inevitably develops.
Anne‐Sophie Hatat +11 more
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Frontiers in Plant Science, 2023 Spliceostatin C (SPC) is a component of a bioherbicide isolated from the soil bacterium Burkholderia rinojensis. The chemical structure of SPC closely resembles spliceostatin A (SPA) which was characterized as an anticancer agent and splicing inhibitor ...
Joanna Bajsa-Hirschel +7 more
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Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
Nature Communications, 2021 Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition
Constantin Cretu +9 more
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A new view of RNA: the 1989 discovery by Sidney Altman and Thomas Cech [PDF]
The Ukrainian Biochemical Journal, 2020 The 1989 Nobel Prize Laureates in Chemistry Sidney Altman and Thomas Robert Cech made one of the most important discoveries in molecular genetics. Independently of each other, they demonstrated new experimental evidence that RNA molecules can not only ...
M. V. Grigorieva +2 more
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Frontiers in Genetics, 2020 A large fraction of DNA variants impairs pre-mRNA splicing in human hereditary disorders. Crigler-Najjar syndrome (CNS) is characterized by a severe unconjugated hyperbilirubinemia caused by variants in the UGT1A1 gene.
Linda Gailite +5 more
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CiLiQuant: Quantification of RNA Junction Reads Based on Their Circular or Linear Transcript Origin
Frontiers in Bioinformatics, 2022 Distinguishing circular RNA reads from reads derived from the linear host transcript is a challenging task because of sequence overlap. We developed a computational approach, CiLiQuant, that determines the relative circular and linear abundance of ...
Annelien Morlion +13 more
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Introns: the “dark matter” of the eukaryotic genome
Frontiers in Genetics, 2023 The emergence of introns was a significant evolutionary leap that is a major distinguishing feature between prokaryotic and eukaryotic genomes. While historically introns were regarded merely as the sequences that are removed to produce spliced ...
Kaitlin N. Girardini +4 more
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Non-Coding RNA, 2022 Ubiquitous eukaryotic non-coding circular RNAs are involved in numerous co- and post-transcriptional regulatory mechanisms. Recently, we reported full-length intronic circular RNAs (flicRNAs) in Entamoeba histolytica, with 3′ss–5′ss ligation points and 5′
Jesús Alberto García-Lerena +3 more
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Identification of Eight Spliceogenic Variants in BRCA2 Exon 16 by Minigene Assays
Frontiers in Genetics, 2018 Genetic testing of BRCA1 and BRCA2 identifies a large number of variants of uncertain clinical significance whose functional and clinical interpretations pose a challenge for genetic counseling.
Eugenia Fraile-Bethencourt +5 more
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The Diverse Genomic Landscape of Diamond–Blackfan Anemia: Two Novel Variants and a Mini-Review
Children, 2023 Diamond–Blackfan anemia (DBA) is a ribosomopathy characterized by bone marrow erythroid hypoplasia, which typically presents with severe anemia within the first months of life. DBA is typically attributed to a heterozygous mutation in a ribosomal protein
Iordanis Pelagiadis +9 more
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