Results 161 to 170 of about 588,446 (356)
Enhanced Performance 3‐D Printed PLA Parts through a Photo‐Initiator Mediated UV‐Curing
This solvent‐free method enhances 3‐D printed PLA parts by incorporating photo‐initiators during fabrication, followed by up to 3 min UV treatment. This process improves PLA's mechanical properties, including a 64% increase in tensile strength, while addressing weak interlayer bonding and outdoor sensitivity.
Dylan Jubinville, Tizazu H. Mekonnen
wiley +1 more source
Fiber Bragg Gratings with Micro‐Engineered Temperature Coefficients
Fiber Bragg gratings (FBGs) are intrinsically responsive to temperature and strain simultaneously. In this research, low‐loss FBGs with micro‐engineered temperature coefficients are fabricated, utilizing refractive index liquid‐filled microchannels in the cladding.
Zipei Song+8 more
wiley +1 more source
Optical Chaos Generation and Applications
This review comprehensively examines optical chaos generation via feedback, injection, and optoelectronic methods, emphasizing bandwidth enhancement and time‐delay suppression. Applications include chaos‐synchronized secure communication, physical random number generation, chaotic lidar for cm‐level detection, distributed fiber sensing, and terahertz ...
Wenhui Chen+8 more
wiley +1 more source
Emerging Therapeutic Strategies for Hearing Loss
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han+9 more
wiley +1 more source
FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang+14 more
wiley +1 more source
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu+7 more
wiley +1 more source
The selection of alternative splice sites is an important component of cell-specific gene regulation in eukaryotic cells. Use of splice sites can be positively and negatively regulated, and often physiologically appropriate splice site choice is achieved by a balance of the two.
openaire +4 more sources
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng+11 more
wiley +1 more source
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du+13 more
wiley +1 more source
Functional analysis of alternatively spliced tyrosinase gene transcripts. [PDF]
Günter Müller+3 more
openalex +1 more source