Results 161 to 170 of about 588,446 (356)

Enhanced Performance 3‐D Printed PLA Parts through a Photo‐Initiator Mediated UV‐Curing

open access: yesAdvanced Materials Technologies, EarlyView.
This solvent‐free method enhances 3‐D printed PLA parts by incorporating photo‐initiators during fabrication, followed by up to 3 min UV treatment. This process improves PLA's mechanical properties, including a 64% increase in tensile strength, while addressing weak interlayer bonding and outdoor sensitivity.
Dylan Jubinville, Tizazu H. Mekonnen
wiley   +1 more source

Fiber Bragg Gratings with Micro‐Engineered Temperature Coefficients

open access: yesAdvanced Optical Materials, Volume 13, Issue 8, March 13, 2025.
Fiber Bragg gratings (FBGs) are intrinsically responsive to temperature and strain simultaneously. In this research, low‐loss FBGs with micro‐engineered temperature coefficients are fabricated, utilizing refractive index liquid‐filled microchannels in the cladding.
Zipei Song   +8 more
wiley   +1 more source

Optical Chaos Generation and Applications

open access: yesAdvanced Photonics Research, EarlyView.
This review comprehensively examines optical chaos generation via feedback, injection, and optoelectronic methods, emphasizing bandwidth enhancement and time‐delay suppression. Applications include chaos‐synchronized secure communication, physical random number generation, chaotic lidar for cm‐level detection, distributed fiber sensing, and terahertz ...
Wenhui Chen   +8 more
wiley   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

open access: yesAdvanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han   +9 more
wiley   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

open access: yesAdvanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang   +14 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

open access: yesAdvanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu   +7 more
wiley   +1 more source

Splicing and the single cell.

open access: yesHistology and histopathology, 2000
The selection of alternative splice sites is an important component of cell-specific gene regulation in eukaryotic cells. Use of splice sites can be positively and negatively regulated, and often physiologically appropriate splice site choice is achieved by a balance of the two.
openaire   +4 more sources

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

open access: yesAdvanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng   +11 more
wiley   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

open access: yesAdvanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du   +13 more
wiley   +1 more source

Functional analysis of alternatively spliced tyrosinase gene transcripts. [PDF]

open access: bronze, 1988
Günter Müller   +3 more
openalex   +1 more source

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