Results 11 to 20 of about 335,173 (238)

Numerical prediction and experimental analysis of ends-together yarn splicing [PDF]

, 2016
Pneumatic yarn splicing is a technical process for joining two yarn ends together. The process involves injecting compressed air into a splicing chamber. The inlet pressure and chamber slope determine the main parameters affecting this process.
De Meulemeester, Simon, Degroote, Joris, Malengier, Benny, Osman, Akil, Vierendeels, Jan   +4 more
core   +1 more source

Minigene Splicing Assays Identify 12 Spliceogenic Variants of BRCA2 Exons 14 and 15

Frontiers in Genetics, 2019
A relevant fraction of BRCA2 variants is associated with splicing alterations and with an increased risk of hereditary breast and ovarian cancer (HBOC). In this work, we have carried out a thorough study of variants from BRCA2 exons 14 and 15 reported at
Eugenia Fraile-Bethencourt, Alberto Valenzuela-Palomo, Beatriz Díez-Gómez, María José Caloca, Susana Gómez-Barrero, Eladio A. Velasco   +5 more
doaj   +1 more source

New Approach for Detection of Normal Alternative Splicing Events and Aberrant Spliceogenic Transcripts with Long-Range PCR and Deep RNA Sequencing

Biology, 2021
RNA sequencing is a promising technique for detecting normal and aberrant RNA isoforms. Here, we present a new single-gene, straightforward 1-day hands-on protocol for detection of splicing alterations with deep RNA sequencing from blood.
Vita Šetrajčič Dragoš, Vida Stegel, Ana Blatnik, Gašper Klančar, Mateja Krajc, Srdjan Novaković   +5 more
doaj   +1 more source

tRNA splicing [PDF]

, 1998
Introns interrupt the continuity of many eukaryal genes, and therefore their removal by splicing is a crucial step in gene expression. Interestingly, even within Eukarya there are at least four splicing mechanisms.
Abelson, John, Li, Hong, Trotta, Christopher R.   +2 more
core   +1 more source

hnRNP A/B Proteins: An Encyclopedic Assessment of Their Roles in Homeostasis and Disease

Biology, 2021
The hnRNP A/B family of proteins is canonically central to cellular RNA metabolism, but due to their highly conserved nature, the functional differences between hnRNP A1, A2/B1, A0, and A3 are often overlooked. In this review, we explore and identify the
Patricia A. Thibault, Aravindhan Ganesan, Subha Kalyaanamoorthy, Joseph-Patrick W. E. Clarke, Hannah E. Salapa, Michael C. Levin   +5 more
doaj   +1 more source

In Vitro Comparison of Sex-Specific Splicing Efficiencies of fem Pre-mRNA under Monoallelic and Heteroallelic Conditions of csd, a Master Sex-Determining Gene in the Honeybee

Journal of Developmental Biology, 2023
The sexual fate of honeybees is determined by the complementary sex determination (CSD) model: heterozygosity at a single locus (the CSD locus) determines femaleness, while hemizygosity or homozygosity at the CSD locus determines maleness.
Yukihiro Suzuki, Takafumi Yamada, Masataka G. Suzuki   +2 more
doaj   +1 more source

Computational prediction of splicing regulatory elements shared by Tetrapoda organisms [PDF]

, 2009
Background: auxiliary splicing sequences play an important role in ensuring accurate and efficient splicing by promoting or repressing recognition of authentic splice sites.
Churbanov, Alexander, Hicks, Chindo, Vořechovský, Igor   +2 more
core   +3 more sources

Cytogenetic and Genetic Abnormalities with Diagnostic Value in Myelodysplastic Syndromes (MDS): Focus on the Pre-Messenger RNA Splicing Process

Diagnostics, 2022
Myelodysplastic syndromes (MDS) are considered to be diseases associated with splicing defects. A large number of genes involved in the pre-messenger RNA splicing process are mutated in MDS.
Nathalie Douet-Guilbert, Benoît Soubise, Delphine G. Bernard, Marie-Bérengère Troadec   +3 more
doaj   +1 more source

Apparent non-canonical trans-splicing is generated by reverse transcriptase in vitro [PDF]

, 2010
Trans-splicing, the in vivo joining of two RNA molecules, is well characterized in several groups of simple organisms but was long thought absent from fungi, plants and mammals.
David Tollervey, DS Rickman, E Gilboa, ES Svarovskaia, F Perocchi, GX Luo, H Li, HM Temin, J Cocquet, J Houseley, J Sambrook, Jonathan Houseley, KEM Hastings, M Geiszt, M Ouhammouch, P Kapranov, P Unneberg, RH Herai, RM Mader, S Zhu, SW Roy, T Horiuchi, Thomas Preiss, TR Gingeras, X Li, X Niu, XC Zeng   +26 more
core   +5 more sources

A novel deep intronic variant in ATP7B in five unrelated families affected by Wilson disease

Molecular Genetics & Genomic Medicine, 2020
Background Wilson disease is an autosomal recessive metabolic disorder resulting from accumulation of excess copper especially in the liver and brain.
France Woimant, Aurelia Poujois, Adrien Bloch, Tabaras Jordi, Jean‐Louis Laplanche, Hélène Morel, Corinne Collet   +6 more
doaj   +1 more source