Results 41 to 50 of about 325,490 (342)
Spliced leader RNA trans-splicing in dinoflagellates [PDF]
Proceedings of the National Academy of Sciences, 2007 Through the analysis of hundreds of full-length cDNAs from fifteen species representing all major orders of dinoflagellates, we demonstrate that nuclear-encoded mRNAs in all species, from ancestral to derived lineages, are trans-spliced with the addition of the 22-nt conserved spliced leader (SL), DCCGUAGCCAUUUUGGCUCAAG (D = U, A, or G), to the 5′ end.
Lilibeth Miranda +6 more
openaire +3 more sources
Frontiers in Molecular Biosciences, 2021 An evolutionarily conserved feature of introns is their ability to enhance expression of genes that harbor them. Introns have been shown to regulate gene expression at the transcription and post-transcription level.
Katherine Dwyer +3 more
doaj +1 more source
Approaches to link RNA secondary structures with splicing regulation [PDF]
Methods Mol Biol. 2014;1126:341-56, 2015 In higher eukaryotes, alternative splicing is usually regulated by protein factors, which bind to the pre-mRNA and affect the recognition of splicing signals. There is recent evidence that the secondary structure of the pre-mRNA may also play an important role in this process, either by facilitating or by hindering the interaction with factors and ...
arxiv +1 more source
Theoretical Computer Science, 1996 AbstractComputing by splicing is a new powerful tool stemming originally from molecular genetics. This new model of computing, splicing systems, is investigated here. Several variants, resulting from the use of the rules in different ways, are considered.
Arto Salomaa +3 more
openaire +1 more source
MicrobiologyOpen, 2021 The expanding knowledge of the variety of synthetic genetic elements has enabled the construction of new and more efficient genetic circuits and yielded novel insights into molecular mechanisms.
Markéta Vlková +2 more
doaj +1 more source
Splicing in the Diagnosis of Rare Disease: Advances and Challenges
Frontiers in Genetics, 2021 Mutations which affect splicing are significant contributors to rare disease, but are frequently overlooked by diagnostic sequencing pipelines. Greater ascertainment of pathogenic splicing variants will increase diagnostic yields, ending the diagnostic ...
Jenny Lord, Diana Baralle, Diana Baralle
doaj +1 more source
Assessing conservation of alternative splicing with evolutionary splicing graphs [PDF]
Genome Research, 2020 Understanding how protein function has evolved and diversified is of great importance for human genetics and medicine. Here, we tackle the problem of describing the whole transcript variability observed in several species by generalizing the definition of splicing graph.
Hugues Richard +5 more
openaire +8 more sources
Frontiers in Genetics, 2021 TYK2 variants can impact disease onset or progression. In our previous study, we identified abnormal splicing that happened near rs781536408 in the TYK2 gene.
Suqing Chen +6 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Dynamics and consequences of spliceosome E complex formation
eLife, 2017 The spliceosome must identify the correct splice sites (SS) and branchsite (BS) used during splicing. E complex is the earliest spliceosome precursor in which the 5' SS and BS are defined.
Joshua Donald Larson, Aaron A Hoskins
doaj +1 more source