Results 51 to 60 of about 603,390 (338)
Spliced leader RNA trans-splicing in dinoflagellates [PDF]
Proceedings of the National Academy of Sciences, 2007 Through the analysis of hundreds of full-length cDNAs from fifteen species representing all major orders of dinoflagellates, we demonstrate that nuclear-encoded mRNAs in all species, from ancestral to derived lineages, are trans-spliced with the addition of the 22-nt conserved spliced leader (SL), DCCGUAGCCAUUUUGGCUCAAG (D = U, A, or G), to the 5′ end.
Lilibeth Miranda +6 more
openaire +3 more sources
Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells [PDF]
, 2015 Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the first-line chemotherapeutic approach.
Bielli, P +7 more
core +5 more sources
eLife, 2019 UPF1 is an RNA helicase that is required for nonsense-mediated mRNA decay (NMD) in eukaryotes, and the predominant view is that UPF1 mainly operates on the 3’UTRs of mRNAs that are directed for NMD in the cytoplasm.
Anand K Singh +10 more
doaj +1 more source
Cells, 2021 Age-related macular degeneration (AMD) is a blinding disease for which most of the patients remain untreatable. Since the disease affects the macula at the center of the retina, a structure specific to the primate lineage, rodent models to study the ...
Laurence Klipfel +10 more
doaj +1 more source
Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer
eLife, 2019 Prostate is the most frequent cancer in men. Prostate cancer progression is driven by androgen steroid hormones, and delayed by androgen deprivation therapy (ADT).
Jennifer Munkley +22 more
doaj +1 more source
A novel synonymous KMT2B variant in a patient with dystonia causes aberrant splicing
Molecular Genetics & Genomic Medicine, 2022 Background Heterozygous KMT2B variants are a common cause of dystonia. A novel synonymous KMT2B variant, c.5073C>T (p.Gly1691=) was identified in an individual with childhood‐onset progressive dystonia.
Bianca R. Grosz +13 more
doaj +1 more source
The CUGBP2 splicing factor regulates an ensemble of branchpoints from perimeter binding sites with implications for autoregulation [PDF]
, 2009 Alternative pre-mRNA splicing adjusts the transcriptional output of the genome by generating related mRNAs from a single primary transcript, thereby expanding protein diversity.
Dembowski, JA, Grabowski, PJ
core +5 more sources
Journal of Topology, 2012 34 pages, 16 diagrams. V3->V4: Explicit definition of sigma^* \wr G-operads given, and proof included splicing operad is such. Re-wrote proof of Theorem 5.13 to make the equivariance of the maps more explicit. Cut down on extraneous notation.
openaire +3 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Synergistic assembly of human pre-spliceosomes across introns and exons
eLife, 2018 Most human genes contain multiple introns, necessitating mechanisms to effectively define exons and ensure their proper connection by spliceosomes. Human spliceosome assembly involves both cross-intron and cross-exon interactions, but how these work ...
Joerg E Braun +3 more
doaj +1 more source