Results 51 to 60 of about 483,589 (358)
Spliced leader RNA trans-splicing in dinoflagellates [PDF]
Proceedings of the National Academy of Sciences, 2007 Through the analysis of hundreds of full-length cDNAs from fifteen species representing all major orders of dinoflagellates, we demonstrate that nuclear-encoded mRNAs in all species, from ancestral to derived lineages, are trans-spliced with the addition of the 22-nt conserved spliced leader (SL), DCCGUAGCCAUUUUGGCUCAAG (D = U, A, or G), to the 5′ end.
Lilibeth Miranda +6 more
openaire +3 more sources
Annotation-free quantification of RNA splicing using LeafCutter
Nature Genetics, 2017 The excision of introns from pre-mRNA is an essential step in mRNA processing. We developed LeafCutter to study sample and population variation in intron splicing.
Yang I. Li +6 more
semanticscholar +1 more source
MicrobiologyOpen, 2021 The expanding knowledge of the variety of synthetic genetic elements has enabled the construction of new and more efficient genetic circuits and yielded novel insights into molecular mechanisms.
Markéta Vlková +2 more
doaj +1 more source
Splicing in the Diagnosis of Rare Disease: Advances and Challenges
Frontiers in Genetics, 2021 Mutations which affect splicing are significant contributors to rare disease, but are frequently overlooked by diagnostic sequencing pipelines. Greater ascertainment of pathogenic splicing variants will increase diagnostic yields, ending the diagnostic ...
Jenny Lord, Diana Baralle, Diana Baralle
doaj +1 more source
Journal of Topology, 2012 34 pages, 16 diagrams. V3->V4: Explicit definition of sigma^* \wr G-operads given, and proof included splicing operad is such. Re-wrote proof of Theorem 5.13 to make the equivariance of the maps more explicit. Cut down on extraneous notation.
openaire +3 more sources
Frontiers in Genetics, 2021 TYK2 variants can impact disease onset or progression. In our previous study, we identified abnormal splicing that happened near rs781536408 in the TYK2 gene.
Suqing Chen +6 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Diverse alternative back-splicing and alternative splicing landscape of circular RNAs
Genome Research, 2016 Circular RNAs (circRNAs) derived from back-spliced exons have been widely identified as being co-expressed with their linear counterparts. A single gene locus can produce multiple circRNAs through alternative back-splice site selection and/or alternative
Xiao-Ou Zhang +7 more
semanticscholar +1 more source
Dynamics and consequences of spliceosome E complex formation
eLife, 2017 The spliceosome must identify the correct splice sites (SS) and branchsite (BS) used during splicing. E complex is the earliest spliceosome precursor in which the 5' SS and BS are defined.
Joshua Donald Larson, Aaron A Hoskins
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source