Results 261 to 270 of about 376,518 (330)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Splicing factor 3b subunit 4 (SF3b4) is mediated by EP300 and CREBBP to promote colorectal cancer (CRC) proliferation by enhancing autophagy. [PDF]

Am J Cancer Res
Wu T, Xiao Z, Su B, Yan Z, Zhao Y, Huang C, Zhou L, Tian H, Zhang G.   +8 more
europepmc   +1 more source

A Glutathione S-Transferase Pi Molecular Glue Tethers Splicing Factors and Remodels Cell Metabolism

David M. Leace, Madeleine L. Ware, Olivia Murtagh, Hsiao-Kuei Tsai, Chin‐Yuan Chang, Ku‐Lung Hsu   +5 more
openalex   +2 more sources

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

Silencing serine/arginine-rich splicing factor 1 to induce apoptosis and autophagy-dependent cell death in cholangiocarcinoma through the correction of oncogenic splicing errors. [PDF]

Anat Cell Biol
Inpad C, Phetchahwang P, Pothipan P, Tangwiriyarotkul P, Hongsrichan N, Horpaopan S, Kaewkong W.   +6 more
europepmc   +1 more source

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

A Ralstonia solanacearum Effector Targets Splicing Factor SR34a to Reprogram Alternative Splicing and Regulate Plant Immunity. [PDF]

Plants (Basel)
Li Y, Kou S.
europepmc   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Defining Splicing Factor Requirements for Androgen Receptor Variant Synthesis in Advanced Prostate Cancer. [PDF]

Mol Cancer Res
Walker L, Duncan R, Adamson B, Kendall H, Brittain N, Luzzi S, Jones D, Chaytor L, Peel S, Crafter C, O'Neill DJ, Gaughan L.   +11 more
europepmc   +1 more source

Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides

Advanced Science, EarlyView.
To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li, Chenguang Yang, Ruihan Dong, Juan Francisco Bada Juarez, Lei Wang, Maximilian Emanuel Wettstein, Dali Wang, Chan Cao, Ying Lu, Chen Song   +9 more
wiley   +1 more source