Results 271 to 280 of about 376,518 (330)

Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading. [PDF]

iScience
Tseng PL, Sun W, Salem A, Alaklobie M, Macfarlane SC, Gad AKB, Collins MO, Erdmann KS.   +7 more
europepmc   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

Splicing factor mutations and cancer.

Splicing factor mutations and cancer.
Recent advances in high-throughput sequencing technologies have unexpectedly revealed that somatic mutations of splicing factor genes frequently occurred in several types of hematological malignancies, including myelodysplastic syndromes, other myeloid neoplasms, and chronic lymphocytic leukemia.
openaire  

The splicing factor kinase, SR protein kinase 1 (SRPK1) is essential for late events in the human papillomavirus life cycle. [PDF]

PLoS Pathog
Faizo AAA, Bellward C, Hernandez-Lopez HR, Stevenson A, Gu Q, Graham SV.   +5 more
europepmc   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

eLife Assessment: Export of discarded splicing intermediates requires mRNA export factors and the nuclear basket [PDF]

Andrés Aguilera
openalex   +1 more source

Deformation Prediction of 4D‐Printed Active Composite Structures Based on Data Mining

Advanced Science, EarlyView.
A curvature‐driven sequence point generation (CSPG) algorithm based on data mining is proposed to predict the deformation of double‐layer voxelized composite structures of arbitrary lengths. In addition, the CSPG algorithm is applied to predict the deformation of 2D and 3D structures assembled from beam elements, and its effectiveness is validated ...
Mengtao Wang, Yifan Xu, Zaiyang Liu, Hidemitsu Furukawa, Zhongkui Wang, Ren Xu, Lin Meng   +6 more
wiley   +1 more source

Identification of new candidate drugs in myelodysplastic syndromes with splicing factor mutations by transcriptional profiling and connectivity map analysis. [PDF]

Br J Haematol
Sun T, Singh S, Wang HC, Lee J, Dolatshad H, Cheong PL, Higgs DR, Boultwood J, Pellagatti A.   +8 more
europepmc   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

CCCTC-binding factor regulates splicing factor proline and glutamine-rich to promote malignant growth of osteosarcoma. [PDF]

Am J Transl Res
Li D, Yang Y, Yin Z, Mao L, Zhang Y, Jiang P, Zhu T, He T, Zhong X, Zheng Q, Zhang W.   +10 more
europepmc   +1 more source