Results 61 to 70 of about 208,874 (142)

N6-Methyladenosine-related alternative splicing events play a role in bladder cancer

Open Life Sciences, 2022
This study investigated the role of N6-methyladenosine (m6A) and alternative splicing (AS) in bladder cancer (BLCA). The BLCA-related RNA expression profiles and AS events were downloaded from the UCSC Xena and SpliceSeq databases, respectively ...
Chang Yuan, Yu Shukun, Zhang Miao, Zhu Xiuyun, Jiang Tianshu, Liu Yuan   +5 more
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Development of a Nomogram With Alternative Splicing Signatures for Predicting the Prognosis of Glioblastoma: A Study Based on Large-Scale Sequencing Data

Frontiers in Oncology, 2020
Purpose: Alternative splicing (AS) was reported to play a vital role in development and progression of glioblastoma (GBM), the most common and fatal brain tumor. Systematic analysis of survival-associated AS event profiles and prognostic prediction model
Zihao Wang, Zihao Wang, Lu Gao, Lu Gao, Xiaopeng Guo, Xiaopeng Guo, Chenzhe Feng, Chenzhe Feng, Wei Lian, Wei Lian, Kan Deng, Kan Deng, Bing Xing, Bing Xing   +13 more
doaj   +1 more source

Genome-Wide Profiling of Alternative Splicing Signature Reveals Prognostic Predictor for Esophageal Carcinoma

Frontiers in Genetics, 2020
BackgroundAlternative splicing (AS) is a molecular event that drives protein diversity through the generation of multiple mRNA isoforms. Growing evidence demonstrates that dysregulation of AS is associated with tumorigenesis.
Jian-Rong Sun, Jian-Rong Sun, Chen-Fan Kong, Chen-Fan Kong, Yan-Ni Lou, Ran Yu, Ran Yu, Xiang-Ke Qu, Xiang-Ke Qu, Li-Qun Jia   +9 more
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CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing

Nature Communications, 2017
U1 snRNP is critical for 5′ splicing site recognition in pre-mRNA splicing. Here the authors describe the cryo-EM structure of the yeast U1 snRNP and suggest that PrpF39 is an alternative splicing factor essential for the successful recruitment of U1 ...
Xueni Li, Shiheng Liu, Jiansen Jiang, Lingdi Zhang, Sara Espinosa, Ryan C. Hill, Kirk C. Hansen, Z. Hong Zhou, Rui Zhao   +8 more
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CWC22 Connects Pre-mRNA Splicing and Exon Junction Complex Assembly

Cell Reports, 2012
The exon junction complex (EJC) is a key regulator of posttranscriptional mRNA fate and binds to mRNA during splicing. Although the composition of EJCs is well understood, the mechanism mediating splicing-dependent EJC assembly and the factor(s ...
Anna-Lena Steckelberg, Volker Boehm, Agnieszka M. Gromadzka, Niels H. Gehring   +3 more
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Spliceosomic dysregulation in pancreatic cancer uncovers splicing factors PRPF8 and RBMX as novel candidate actionable targets

Molecular Oncology
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, characterized by late diagnosis and poor treatment response. Surgery is the only curative approach, only available to early‐diagnosed patients.
Emilia Alors‐Pérez, Ricardo Blázquez‐Encinas, María Trinidad Moreno‐Montilla, Víctor García‐Vioque, Juan Manuel Jiménez‐Vacas, Andrea Mafficini, Iranzu González‐Borja, Claudio Luchini, Juan M. Sánchez‐Hidalgo, Marina E. Sánchez‐Frías, Sergio Pedraza‐Arevalo, Antonio Romero‐Ruiz, Rita T. Lawlor, Antonio Viúdez, Manuel D. Gahete, Aldo Scarpa, Álvaro Arjona‐Sánchez, Raúl M. Luque, Alejandro Ibáñez‐Costa, Justo P. Castaño   +19 more
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PTBP1 Regulates DNMT3B Alternative Splicing by Interacting With RALY to Enhance the Radioresistance of Prostate Cancer

Advanced Science
Radiotherapy is a curative arsenal for prostate cancer (PCa), but radioresistance seriously compromises its effectiveness. Dysregulated RNA splicing factors are extensively involved in tumor progression.
Haixia He, Qianghua Zhou, Yangjie Zhang, Yi Li, Lin Ding, Ting Shen, Sen Liu, Shengmeng Peng, Ming Huang, Hua Zhou, Liang Cheng, Ruihui Xie, Qiang Zhang, Junlin Lu, Liting Li, Jing Yang, Shoumin Bai, Tianxin Lin, Xu Chen   +18 more
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Genome-Wide Profiling Reveals the Landscape of Prognostic Alternative Splicing Signatures in Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2019
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive lethal malignancy. Identification of potential alternative splicing (AS) prognostic indicators and related splicing pathways for the prediction of PDAC outcomes is lacking but urgently needed.
Chengkun Yang, Qiongyuan Wu, Ketuan Huang, Xiangkun Wang, Tingdong Yu, Xiwen Liao, Jianlu Huang, Guangzhi Zhu, Yizhen Gong, Chuangye Han, Hao Su, Wei Qin, Tao Peng   +12 more
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SNRPB promotes gastric cancer progression by regulating aberrant splicing of PUF60

Cell Death and Disease
Alternative splicing is a pivotal regulatory mechanism in cellular biology that critically influences the tumorigenesis, progression, and phenotypic diversity of cancer.
Dan Xiang, Jiaxin Yang, Miaofang Xiao, Cong Long, Yangxuan Lin, Chenchen Mao, Xin Liu, Dianfeng Mei, Wangkai Xie, Zheng Han, Chenbin Chen, Xiaoming Lin, Xian Shen, Xiangyang Xue, Tanzhou Chen   +14 more
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PSF (PTB-associated splicing factor) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on PSF (PTB-associated splicing factor), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +1 more source