Results 71 to 80 of about 376,518 (330)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Regulation of alternative splicing by p300-mediated acetylation of splicing factors [PDF]

RNA, 2019
Splicing of precursor mRNA (pre-mRNA) is an important regulatory step in gene expression. Recent evidence points to a regulatory role of chromatin-related proteins in alternative splicing regulation. Using an unbiased approach, we have identified the acetyltransferase p300 as a key chromatin-related regulator of alternative splicing.
Siam, Ahmad, Baker, Mai, Amit, Leah, Regev, Gal, Rabner, Alona, Najar, Rauf Ahmad, Bentata, Mercedes, Dahan, Sara, Cohen, Klil, Araten, Sarah, Nevo, Yuval, Kay, Gillian, Mandel-Gutfreund, Yael, Salton, Maayan   +13 more
openaire   +2 more sources

Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m7 guanosine cap [PDF]

, 2001
In eukaryotes the majority of mRNAs have an m7G cap that is added cotranscriptionally and that plays an important role in many aspects of mRNA metabolism.
Afonina E., Boisvert F. M., Bushell M., Carmo-Fonseca M., Cho E. J., Dostie J., Dostie J., Ferreira J. A., Flaherty S. M., Fornerod M., Fortes P., Fortes P., Fraser C. S., Fromont-Racine M., Fu X. D., Gingras A. C., Gorlich D., Hentze M., Ho C. K., Izaurralde E., Izaurralde E., Jarmolowski A., Kataoka N., Kim C. Y., Kudo N., Le Hir H., Le Hir H., Lewis J. D., Lewis J. D., Lewis J. D., Lewis J. D., Martins L. M., McCracken S., Milligan J. F., Morley S. J., Morley S. J., Neugebauer K. M., Neugebauer K. M., Ohno M., Pettersson I., Piron M., Ponting C. P., Preiss T., Rozen F., Salditt-Georgieff M., Schaegger H., Shatkin A. J., Stade K., Visa N., Watanabe M., Zhou Z.   +50 more
core   +2 more sources

RNPS1 in PSAP complex controls periodic pre-mRNA splicing over the cell cycle

iScience
Summary: Cell cycle progression requires periodic gene expression through splicing control. However, the splicing factor that directly controls this cell cycle-dependent splicing remains unknown.
Kazuhiro Fukumura, Akio Masuda, Jun-ichi Takeda, Osamu Nagano, Hideyuki Saya, Kinji Ohno, Akila Mayeda   +6 more
doaj   +1 more source

Rapid Regulation of Alternative Splicing in Response to Environmental Stresses

Frontiers in Plant Science, 2022
Plants overcome the changing environmental conditions through diverse strategies and complex regulations. In addition to direct regulation of gene transcription, alternative splicing (AS) also acts as a crucial regulatory mechanism to cope with various ...
Xiao-Xiao Liu, Qian-Huan Guo, Wei-Bo Xu, Peng Liu, Kang Yan   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Social system of transition society theoretical scheme: economy, culture and ecology interrelations [PDF]

, 2009
Changes in transcription factor levels, epigenetic status, splicing kinetics and mRNA degradation can each contribute to changes in the mRNA dynamics of a gene.
Blom, J.G. (Joke), Bruggeman, F.J. (Frank), Carlberg, C., Mourik, S. (Simon) van, Rybakova, K.N., Tomaszewska, A., Westerhoff, H.V. (Hans)   +6 more
core   +4 more sources

MeCP2 regulates Tet1-catalyzed demethylation, CTCF binding, and learning-dependent alternative splicing of the BDNF gene in Turtle

eLife, 2017
MECP2 mutations underlying Rett syndrome cause widespread misregulation of gene expression. Functions for MeCP2 other than transcriptional are not well understood.
Zhaoqing Zheng, Ganesh Ambigapathy, Joyce Keifer   +2 more
doaj   +1 more source

Systematic Profiling of Alternative Splicing Events in Ovarian Cancer

Frontiers in Oncology, 2021
Alternative splicing (AS) is significantly related to the development of tumor and the clinical outcome of patients. In this study, our aim was to systematically analyze the survival-related AS signal in ovarian serous cystadenocarcinoma (OV) and ...
Jia Liu, Dekang Lv, Xiaobin Wang, Ruicong Wang, Xiaodong Li   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source