Results 171 to 180 of about 7,687,875 (261)

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

At-RS31 orchestrates hierarchical cross-regulation of splicing factors and integrates alternative splicing with TOR-ABA pathways. [PDF]

New Phytol
Köster T, Venhuizen P, Lewinski M, Petrillo E, Marquez Y, Fuchs A, Ray D, Nimeth BA, Riegler S, Franzmeier S, Rodríguez FS, Aballay FE, Tognacca RS, Zheng H, Hughes T, Morris Q, Barta A, Staiger D, Kalyna M.   +18 more
europepmc   +2 more sources

Landscape of splicing factors in early-onset gastric cancer reveals SRSF1 as a key driver of oxaliplatin resistance. [PDF]

J Biol Chem
Zhong B, Xiong Z, Xu H, Zheng J, Mohamed SA, Sun J, Huang D, Deng Z, Guo J, Peng J, Chen Y, Lian L.   +11 more
europepmc   +1 more source

Towards understandings of serine/arginine-rich splicing factors. [PDF]

Acta Pharm Sin B, 2023
Li D, Yu W, Lai M.
europepmc   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Activation and Spatial Redistribution of RNA Splicing Factors Trigger Hepatic Regeneration. [PDF]

Cell Mol Gastroenterol Hepatol
An Y, Lian J, Wei W, Mao Y, Qiao L, Li T, Li R, Li S, Zhao S, Chen X, Zhao H, Hu H.   +11 more
europepmc   +1 more source

Molecular characteristics and clinical implications of serine/arginine-rich splicing factors in human cancer. [PDF]

Aging (Albany NY), 2023
Zhang J, Fang Z, Song C.
europepmc   +1 more source

An RNA‐Binding Protein RBMS1 Promotes Endothelial Cell Autophagy to Maintain Vascular Homeostasis and Suppress Deep Vein Thrombosis

Advanced Science, EarlyView.
RBMS1, an RNA‐binding protein, restores vascular endothelial homeostasis by enhancing ATG3‐mediated autophagy, thereby attenuating thrombus formation and suggesting a potential avenue for further therapeutic exploration in DVT. ABSTRACT Deep vein thrombosis (DVT) is a prevalent vascular disorder characterized by aberrant coagulation within the deep ...
Chu Chu, Xinkui Liu, Nannan Fan, Xiaoyan Yu, Qiaoqiao Han, Yunhong Zhang, Wei Li, Yongqing Cai, Miaomiao Zhou, Fang Li, Feifei Shi, Zhen Zhang, Bin Wang, Xia Li   +13 more
wiley   +1 more source

MYC-mediated transcriptional control of splicing factors promotes RNA splicing in activated B lymphocytes. [PDF]

Sci Rep
Li S, Yang C, Li J, Liu Z, Gong F, Ke X, Ruan GX, Huang H.   +7 more
europepmc   +1 more source

Comprehensively analysis of splicing factors to construct prognosis prediction classifier in prostate cancer. [PDF]

J Cell Mol Med, 2023
Zhang H, Tian J, Ren S, Han B, Tian R, Zuo X, Liu H, Wang Z, Cui Y, Liu L, Guo H, Zhang F, Niu R.   +12 more
europepmc   +1 more source