Results 171 to 180 of about 215,491 (295)

SplicingLore: a web resource for studying the regulation of cassette exons by human splicing factors. [PDF]

Database (Oxford), 2023
Polvèche H, Valat J, Fontrodona N, Lapendry A, Clerc V, Janczarski S, Mortreux F, Auboeuf D, Bourgeois CF.   +8 more
europepmc   +1 more source

A Unifying Mechanism for Shared Splicing Aberrations in Splicing Factor Mutant Cancers

Abstract Cancer-associated splicing factor (SF) mutations in SF3B1 , U2AF1 , and SRSF2 induce distinct changes in alternative splicing (AS).
Boddu, Prajwal C., Roy, Rahul, Hutter, Stephen, Baumgartner, Francis, Li, Wenxue, Todisco, Gabriele, Ficara, Francesca, Della Porta, Matteo Giovanni, Liu, Yansheng, Haferlach, Torsten, Pillai, Manoj M.   +10 more
openaire   +3 more sources

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

The role of FUS in splicing regulation

, 2014
Fused in sarcoma (FUS), also called translocated in liposarcoma (TLS), is a ubiquitously expressed DNA/RNA binding protein belonging to the TET family and predominantly localized in the nucleus.
Ruepp, Marc-David
core  

Landscape of splicing factors in early-onset gastric cancer reveals SRSF1 as a key driver of oxaliplatin resistance. [PDF]

J Biol Chem
Zhong B, Xiong Z, Xu H, Zheng J, Mohamed SA, Sun J, Huang D, Deng Z, Guo J, Peng J, Chen Y, Lian L.   +11 more
europepmc   +1 more source

Towards understandings of serine/arginine-rich splicing factors. [PDF]

Acta Pharm Sin B, 2023
Li D, Yu W, Lai M.
europepmc   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Interdependent Regulation of Alternative Splicing by Serine/Arginine-Rich and Heterogeneous Nuclear Ribonucleoprotein Splicing Factors. [PDF]

Genes (Basel)
Holmes ME, Hertel KJ.
europepmc   +1 more source

Molecular characteristics and clinical implications of serine/arginine-rich splicing factors in human cancer. [PDF]

Aging (Albany NY), 2023
Zhang J, Fang Z, Song C.
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source