Results 1 to 10 of about 3,491 (191)

Fluctuations in spo0A transcription control rare developmental transitions in Bacillus subtilis. [PDF]

PLoS Genetics, 2011
Phosphorylated Spo0A is a master regulator of stationary phase development in the model bacterium Bacillus subtilis, controlling the formation of spores, biofilms, and cells competent for transformation. We have monitored the rate of transcription of the
Nicolas Mirouze, Peter Prepiak, David Dubnau   +2 more
doaj   +5 more sources

Changes in Spo0A~P pulsing frequency control biofilm matrix deactivation. [PDF]

PLoS Comput Biol
Under starvation conditions, B. subtilis survives by differentiating into one of two cell types: biofilm matrix-producing cells or sporulating cells. These two cell-differentiation pathways are activated by the same phosphorylated transcription factor ...
Palma CSD, Haller DJ, Tabor JJ, Igoshin OA.   +3 more
europepmc   +5 more sources

Transcription Factor Spo0A Regulates the Biosynthesis of Difficidin in Bacillus amyloliquefaciens

Microbiology Spectrum, 2023
Bacillus amyloliquefaciens WH1 produces multiple antibiotics with antimicrobial activity and can control bacterial wilt disease caused by Ralstonia solanacearum. Antibacterial substances produced by WH1 and the regulation mechanism are unknown.
Na Liu, Huiwan Sun, Zhengyu Tang, Yuqing Zheng, Gaofu Qi, Xiuyun Zhao   +5 more
doaj   +3 more sources

Spo0A Suppresses sin Locus Expression in Clostridioides difficile

mSphere, 2020
Clostridioides difficile is the leading cause of nosocomial infection and is the causative agent of antibiotic-associated diarrhea. The severity of the disease is directly associated with toxin production, and spores are responsible for the transmission ...
Babita Adhikari Dhungel, Revathi Govind
doaj   +3 more sources

Biophysical modeling reveals the transcriptional regulatory mechanism of Spo0A, the master regulator in starving <i>Bacillus subtilis</i>. [PDF]

mSystems
In starving Bacillus subtilis bacteria, the initiation of two survival programs—biofilm formation and sporulation—is controlled by the same phosphorylated master regulator, Spo0A~P. Its gene, spo0A, is transcribed from two promoters, Pv and Ps, that are,
Zhang Y, Palma CSD, Chen Z, Zarazúa-Osorio B, Fujita M, Igoshin OA.   +5 more
europepmc   +2 more sources

Essential oils and Lactobacillus metabolites as alternative antibiofilm agents against foodborne bacteria and molecular analysis of biofilm regulatory genes. [PDF]

Sci Rep
The formation of biofilm by foodborne pathogens increases the risk of foodborne diseases, resulting in major health risks. Research on strategies for eliminating biofilm formation by foodborne pathogens is urgently needed.
Ammar HA, Samy R, Reda FM, Hassanein WA.
europepmc   +2 more sources

Bacillus subtilis Histidine Kinase KinC Activates Biofilm Formation by Controlling Heterogeneity of Single-Cell Responses

mBio, 2022
In Bacillus subtilis, biofilm and sporulation pathways are both controlled by a master regulator, Spo0A, which is activated by phosphorylation via a phosphorelay—a cascade of phosphotransfer reactions commencing with autophosphorylation of histidine ...
Zhuo Chen, Priyanka Srivastava, Brenda Zarazúa-Osorio, Anuradha Marathe, Masaya Fujita, Oleg A. Igoshin   +5 more
doaj   +1 more source

Spo0A differentially regulates toxin production in evolutionarily diverse strains of Clostridium difficile. [PDF]

PLoS ONE, 2013
Clostridium difficile is an important pathogen of humans and animals, representing a significant global healthcare problem. The last decade has seen the emergence of epidemic BI/NAP1/027 and ribotype 078 isolates, associated with the onset of more severe
Kate E Mackin, Glen P Carter, Pauline Howarth, Julian I Rood, Dena Lyras   +4 more
doaj   +1 more source

Fusaricidin Biosynthesis Is Controlled via a KinB-Spo0A-AbrB Signal Pathway in Paenibacillus polymyxa WLY78

Molecular Plant-Microbe Interactions, 2021
Fusaricidins produced by Paenibacillus polymyxa are important lipopeptide antibiotics against fungi. The fusGFEDCBA (fusaricidin biosynthesis) operon is responsible for synthesis of fusaricidins.
Yunlong Li, Haowei Zhang, Yongbin Li, Sanfeng Chen   +3 more
doaj   +1 more source

The Slowdown of Growth Rate Controls the Single-Cell Distribution of Biofilm Matrix Production via an SinI-SinR-SlrR Network

mSystems, 2023
In Bacillus subtilis, master regulator Spo0A controls several cell-differentiation pathways. Under moderate starvation, phosphorylated Spo0A (Spo0A~P) induces biofilm formation by indirectly activating genes controlling matrix production in a ...
Zhuo Chen, Brenda Zarazúa-Osorio, Priyanka Srivastava, Masaya Fujita, Oleg A. Igoshin   +4 more
doaj   +1 more source