Results 11 to 20 of about 3,491 (191)
Inducible Expression of spo0A as a Universal Tool for Studying Sporulation in Clostridium difficile [PDF]
Frontiers in Microbiology, 2017 Clostridium difficile remains a leading nosocomial pathogen, putting considerable strain on the healthcare system. The ability to form endospores, highly resistant to environmental insults, is key to its persistence and transmission.
Marcin Dembek +5 more
doaj +10 more sources
Dimer‐induced signal propagation in Spo0A [PDF]
Molecular Microbiology, 2004 SummarySpo0A, the response regulator protein controlling the initiation of sporulation in Bacillus, has two distinct domains, an N‐terminal phosphoacceptor (or receiver) domain and a C‐terminal DNA‐binding (or effector) domain. The phosphoacceptor domain mediates dimerization of Spo0A on phosphorylation.
Muchova, K +7 more
openaire +9 more sources
The Spo0A regulon of Bacillus subtilis [PDF]
Molecular Microbiology, 2003 Summary The master regulator for entry into sporulation in Bacillus subtilis is the DNA‐binding protein Spo0A, which has been found to influence, directly or indirectly, the expression of over 500 genes during the early stages of development. To search on a genome‐wide basis
Molle, Virginie +6 more
openaire +4 more sources
The Clostridium difficile spo0A Gene Is a Persistence and Transmission Factor [PDF]
Infection and Immunity, 2012 ABSTRACT Clostridium difficile is a major cause of chronic antibiotic-associated diarrhea and a significant health care-associated pathogen that forms highly resistant and infectious spores. Spo0A is a highly conserved transcriptional regulator that plays a key role in initiating sporulation in Bacillus
Deakin, L.J. +9 more
openaire +5 more sources
Clostridium beijerinckii strain degeneration is driven by the loss of Spo0A activity
Frontiers in Microbiology, 2023 Solventogenic clostridia represent a diverse group of anaerobic, spore-forming bacteria capable of producing acetone, butanol and ethanol through their unique biphasic metabolism.
Jonathan R. Humphreys +3 more
doaj +3 more sources
Characterisation of Clostridium difficile biofilm formation, a role for Spo0A. [PDF]
PLoS ONE, 2012 Clostridium difficile is a Gram-positive anaerobic, spore-forming bacillus that is the leading cause of nosocomial diarrhoea worldwide. We demonstrate that C. difficile aggregates and forms biofilms in vitro on abiotic surfaces.
Lisa F Dawson +4 more
doaj +3 more sources
PLoS ONE, 2012 Clostridium difficile is a Gram positive, anaerobic bacterium that can form highly resistant endospores. The bacterium is the causative agent of C. difficile infection (CDI), for which the symptoms can range from a mild diarrhea to potentially fatal ...
Katharina E Rosenbusch +3 more
doaj +2 more sources
Just-in-Time Control of Spo0A Synthesis in Bacillus subtilis by Multiple Regulatory Mechanisms [PDF]
Journal of Bacteriology, 2011 ABSTRACT The response regulator Spo0A governs multiple developmental processes in Bacillus subtilis , including most conspicuously sporulation. Spo0A is activated by phosphorylation via a multicomponent phosphorelay.
Chastanet, Arnaud, Losick, Richard
openaire +5 more sources
Spo0A~P imposes a temporal gate for the bimodal expression of competence in Bacillus subtilis. [PDF]
PLoS Genetics, 2012 ComK transcriptionally controls competence for the uptake of transforming DNA in Bacillus subtilis. Only 10%-20% of the cells in a clonal population are randomly selected for competence.
Nicolas Mirouze +3 more
doaj +4 more sources
An SPFH Protein Couples Membrane Stress to Differentiation in Bacillus subtilis. [PDF]
Environ MicrobiolThe SPFH protein SamI and the integral membrane proteins SamG and SamH form the SamIGH complex, linking envelope stress signalling to developmental programs in Bacillus subtilis. Loss of SamI causes chronic envelope stress signalling and impairs biofilm development, resulting in reduced structural complexity.
Baur SSM +5 more
europepmc +2 more sources