Results 91 to 100 of about 74,670 (239)

Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2–HO‐1 Pathway

Phytotherapy Research, EarlyView.
ABSTRACT Osteoporosis, characterized by osteoclastic bone resorption, has been the focus of research. Studies implicate that reactive oxygen species (ROS) accumulate intracellularly during osteoclastogenesis. Salvianolic acid A (SAA), a compound derived from Salvia miltiorrhiza, has been widely used to treat cardiovascular and cerebrovascular disorders,
Hao Qiu, Chenhui Cai, Ying Zhang, Sizhen Yang, Xu Hu, Tongwei Chu   +5 more
wiley   +1 more source

OSTEOPOROSIS IN PATIENTS WITH ANKYLOSING SPONDYLITIS

Фундаментальная и клиническая медицина, 2019
Currently, rheumatologists consider osteoporosis as a complication of ankylosing spondylitis, however, in recent years, it is discussed as a comorbidity but not a complication.
TATIANA A. Raskina, OLGA S. Malyshenko, OKSANA A. Pirogova, INESSA I. Grigorieva   +3 more
doaj  

Effects of psoriatic arthritis‐targeted drugs on bone remodeling: Clinical evidence and molecular pathways

Rheumatology &Autoimmunity, EarlyView.
Mechanisms and therapeutic targets in psoriatic arthritis: balancing inflammatory bone resorption and bone formation. Abstract Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized by diverse clinical manifestations. Of particular concern, osteopenia and osteoporosis are prevalent in 45.27% and 12.94% of PsA patients, respectively ...
Yingchao Sun, Cheng Xu, Mingli Ouyang, Yongmei Han   +3 more
wiley   +1 more source

ERAP1 and ankylosing spondylitis

Current Opinion in Immunology, 2013
The strong genetic association of ERAP1 (endoplasmic reticulum aminopeptidase 1) with ankylosing spondylitis (AS), which is restricted to HLA-B27 positive cases, has profound pathogenetic implications. ERAP1 is involved in trimming peptides to optimal length for binding to HLA class 1 molecules, thereby not only affecting the stability and processing ...
Keidel, S, Chen, L, Pointon, J, Wordsworth, B   +3 more
openaire   +4 more sources

Comparative Effectiveness and Safety of Adalimumab, Secukinumab, and Upadacitinib in Psoriatic Arthritis: A Prospective Cohort Study Based on PARWCH Cohort

The Journal of Dermatology, EarlyView.
ABSTRACT Psoriatic arthritis (PsA) is a chronic inflammatory disease, with prevalence among psoriasis patients ranging from 6% to 42% across populations. Although targeted therapies such as adalimumab (ADA), secukinumab (SEC), and upadacitinib (UPA) have demonstrated efficacy in randomized controlled trials, real‐world head‐to‐head comparisons remain ...
Yiyi Wang, Jingya Gao, Furong Li, Luyuan Li, Yue Xiao, Hongxiang Hu, Xiya Peng, Min Yang, Dan Hao, Wei Yan, Dengmei Xia, Wei Li   +11 more
wiley   +1 more source

Biomechanical assessment of balance and posture in subjects with ankylosing spondylitis

Journal of NeuroEngineering and Rehabilitation, 2012
Background Ankylosing spondylitis is a major chronic rheumatic disease that predominantly affects axial joints, determining a rigid spine from the occiput to the sacrum. The dorsal hyperkyphosis may induce the patients to stand in a stooped position with
Sawacha Zimi, Carraro Elena, Del Din Silvia, Guiotto Annamaria, Bonaldo Lara, Punzi Leonardo, Cobelli Claudio, Masiero Stefano   +7 more
doaj   +1 more source

HLA-B27 Positivity: associated health implications [PDF]

, 2011
HLA-B27 positivity makes the onset of autoimmune diseases such as uveitis, ankylosing spondylitis and Crohn's disease more likely to occur. Ankylosing spondylitis and Crohn's disease are two types of HLA-B27 positive diseases that demonstrate a direct ...
Cox, C. L., Evans, P., Gibbons, H., Titmus, K., Withers, T.   +4 more
core   +1 more source

Retrospective Review on Safety and Efficacy of Combination Biologic Therapy for Psoriasis

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Background There is limited data on the use of dual or combination biologic therapy in dermatological patients, particularly in psoriasis or with other coexisting dermatological conditions. However, this may be necessary for a small proportion of patients.
Nicole Kah Mun Yoong, Xin Lin Wong, John Sullivan   +2 more
wiley   +1 more source

Quantification of paravertebral cross-sectional muscle areas and fatty degeneration and their correlation with clinical parameters in ankylosing spondylitis: a comprehensive analysis [PDF]

ARP Rheumatology
Aims: Ankylosing spondylitis (AS) is a chronic disease characterized by inflammation of the spine and joints. This study aimed to examine the multifidus (MF) and erector spinae (ES) muscles in AS patients using magnetic resonance imaging (MRI), and to ...
Selçuk Akkaya, Gonca Sağlam Akkaya, Serpil Demirulus, Hanife Baykal Şahin, Gamze Kılıç, Erhan Çapkın, Murat Karkucak   +6 more
doaj  

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?

Clinics
OBJECTIVE: Nitric oxide is produced by endothelial nitric oxide synthase, and its production can be influenced by polymorphisms of the endothelial nitric oxide synthase gene.
Ismail Sari, Yusuf Ziya Igci, Gercek Can, Ali Taylan, Dilek Solmaz, Bulent Gogebakan, Servet Akar, Zeynep Eslik, Giray Bozkaya, Nurullah Akkoc   +9 more
doaj   +1 more source