Results 11 to 20 of about 2,106 (149)

Emerging therapeutic options for sporadic inclusion body myositis [PDF]

Therapeutics and Clinical Risk Management, 2015
Lindsay N Alfano, Linda P Lowes Nationwide Children’s Hospital, Center for Gene Therapy, Columbus, OH, USA Abstract: Sporadic inclusion body myositis is the most common inflammatory muscle disorder preferentially affecting males over the age of ...
Alfano LN, Lowes LP
doaj   +6 more sources

COVID-19-Induced Sporadic Inclusion Body Myositis. [PDF]

Cureus, 2022
Sporadic inclusion body myositis (sIBM) is an autoimmune condition that is characterized by progressive weakness and muscular atrophy in the extremities. The pathophysiology is not exactly clear; however, some studies have postulated an involvement of cytotoxic T cells (CD8+), causing an autoimmune response. While the implications of COVID-19 infection
Dalal F, Dalal H, McNew G.
europepmc   +3 more sources

Mitochondrial defects in sporadic inclusion body myositis—causes and consequences [PDF]

Frontiers in Cell and Developmental Biology
Sporadic inclusion body myositis (sIBM) is a distinct subcategory of Idiopathic Inflammatory Myopathies (IIM), characterized by unique pathological features such as muscle inflammation, rimmed vacuoles, and protein aggregation within the myofibers ...
Elsie Chit Yu Iu, Ho So, Chi Bun Chan
doaj   +2 more sources

Impact of a Ketogenic Diet on Sporadic Inclusion Body Myositis: A Case Study [PDF]

Frontiers in Neurology, 2020
Sporadic inclusion body myositis (IBM) is a chronic inflammatory and degenerative muscle disease with limited treatment options; no therapy can alter its natural course.
Matthew C. L. Phillips, Deborah K. J. Murtagh, Fouzia Ziad, Samuel E. Johnston, Ben G. Moon   +4 more
doaj   +2 more sources

Ongoing developments in sporadic inclusion body myositis. [PDF]

Curr Rheumatol Rep, 2014
Sporadic inclusion body myositis (IBM) is an acquired muscle disorder associated with ageing, for which there is no effective treatment. Ongoing developments include: genetic studies that may provide insights regarding the pathogenesis of IBM, improved histopathological markers, the description of a new IBM autoantibody, scrutiny of the diagnostic ...
Machado PM, Ahmed M, Brady S, Gang Q, Healy E, Morrow JM, Wallace AC, Dewar L, Ramdharry G, Parton M, Holton JL, Houlden H, Greensmith L, Hanna MG.   +13 more
europepmc   +6 more sources

Retrospective Study Shows That Serum Levels of Chemokine CXCL10 and Cytokine GDF15 Support a Diagnosis of Sporadic Inclusion Body Myositis and Immune-Mediated Necrotizing Myopathy [PDF]

Brain Sciences, 2023
The implementation of novel blood-based biomarkers is desired to reduce the diagnostic delay and burden for myositis patients. In this retrospective study, the potential of C-X-C motif chemokine ligand 10 (CXCL10) and growth differentiation factor 15 ...
Boel De Paepe, Ken R. Bracke, Jan L. De Bleecker   +2 more
doaj   +2 more sources

Feeder-supported in vitro exercise model using human satellite cells from patients with sporadic inclusion body myositis [PDF]

Scientific Reports, 2022
Contractile activity is a fundamental property of skeletal muscles. We describe the establishment of a “feeder-supported in vitro exercise model” using human-origin primary satellite cells, allowing highly-developed contractile myotubes to readily be ...
Yuqing Li, Weijian Chen, Kazumi Ogawa, Masashi Koide, Tadahisa Takahashi, Yoshihiro Hagiwara, Eiji Itoi, Toshimi Aizawa, Masahiro Tsuchiya, Rumiko Izumi, Naoki Suzuki, Masashi Aoki, Makoto Kanzaki   +12 more
doaj   +2 more sources

Sporadic inclusion body myositis-derived myotube culture revealed muscle cell-autonomous expression profiles. [PDF]

PLoS ONE
Sporadic inclusion body myositis (sIBM) is a muscle disease in older people and is characterized by inflammatory cell invasion into intact muscle fibers and rimmed vacuoles.
Naoki Suzuki, Makoto Kanzaki, Masashi Koide, Rumiko Izumi, Ryo Fujita, Tadahisa Takahashi, Kazumi Ogawa, Yutaka Yabe, Masahiro Tsuchiya, Masako Suzuki, Ryuhei Harada, Akiyuki Ohno, Hiroya Ono, Naoko Nakamura, Kensuke Ikeda, Hitoshi Warita, Shion Osana, Yoshitsugu Oikawa, Takafumi Toyohara, Takaaki Abe, Muliang Rui, Satoru Ebihara, Ryoichi Nagatomi, Yoshihiro Hagiwara, Masashi Aoki   +24 more
doaj   +2 more sources

Multicenter questionnaire survey for sporadic inclusion body myositis in Japan [PDF]

Orphanet Journal of Rare Diseases, 2016
Background Sporadic inclusion body myositis (sIBM) is the most prevalent acquired muscle disease in the elderly. sIBM is an intractable and progressive disease of unknown cause and without effective treatment.
Naoki Suzuki, Madoka Mori-Yoshimura, Satoshi Yamashita, Satoshi Nakano, Ken-ya Murata, Yukie Inamori, Naoko Matsui, En Kimura, Hirofumi Kusaka, Tomoyoshi Kondo, Itsuro Higuchi, Ryuji Kaji, Maki Tateyama, Rumiko Izumi, Hiroya Ono, Masaaki Kato, Hitoshi Warita, Toshiaki Takahashi, Ichizo Nishino, Masashi Aoki   +19 more
doaj   +2 more sources

The updated retrospective questionnaire study of sporadic inclusion body myositis in Japan [PDF]

Orphanet Journal of Rare Diseases, 2019
Background Sporadic inclusion body myositis (sIBM) is the most prevalent muscle disease in elderly people, affecting the daily activities. sIBM is progressive with unknown cause and without effective treatment.
Naoki Suzuki, Madoka Mori-Yoshimura, Satoshi Yamashita, Satoshi Nakano, Ken-ya Murata, Megumi Mori, Yukie Inamori, Naoko Matsui, En Kimura, Hirofumi Kusaka, Tomoyoshi Kondo, Hidefumi Ito, Itsuro Higuchi, Akihiro Hashiguchi, Hiroyuki Nodera, Ryuji Kaji, Maki Tateyama, Rumiko Izumi, Hiroya Ono, Masaaki Kato, Hitoshi Warita, Toshiaki Takahashi, Ichizo Nishino, Masashi Aoki   +23 more
doaj   +2 more sources