Results 21 to 30 of about 2,106 (149)

Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-5. [PDF]

PLoS ONE, 2020
Sporadic inclusion body myositis (sIBM) is the most common idiopathic inflammatory myopathy, and several reports have suggested that mitochondrial abnormalities are involved in its etiology. We recruited 9 sIBM patients and found significant histological
Yoshitsugu Oikawa, Rumiko Izumi, Masashi Koide, Yoshihiro Hagiwara, Makoto Kanzaki, Naoki Suzuki, Koichi Kikuchi, Tetsuro Matsuhashi, Yukako Akiyama, Mariko Ichijo, Shun Watanabe, Takafumi Toyohara, Takehiro Suzuki, Eikan Mishima, Yasutoshi Akiyama, Yoshiaki Ogata, Chitose Suzuki, Hironori Hayashi, Eiichi N Kodama, Ken-Ichiro Hayashi, Eiji Itoi, Masashi Aoki, Shigeo Kure, Takaaki Abe   +23 more
doaj   +2 more sources

Treatment of sporadic inclusion body myositis with bimagrumab. [PDF]

Neurology, 2014
To study activin signaling and its blockade in sporadic inclusion body myositis (sIBM) through translational studies and a randomized controlled trial.We measured transforming growth factor β signaling by SMAD2/3 phosphorylation in muscle biopsies of 50 patients with neuromuscular disease (17 with sIBM).
Amato AA, Sivakumar K, Goyal N, David WS, Salajegheh M, Praestgaard J, Lach-Trifilieff E, Trendelenburg AU, Laurent D, Glass DJ, Roubenoff R, Tseng BS, Greenberg SA.   +12 more
europepmc   +4 more sources

Sporadic inclusion body myositis: new insights and potential therapy. [PDF]

Curr Opin Neurol, 2014
To describe new insights and developments in the pathogenesis, diagnosis and treatment of sporadic inclusion body myositis (IBM).Various hypothesis about the pathogenesis of IBM continue to be investigated, including autoimmune factors, mitochondrial dysfunction, protein dyshomeostasis, altered nucleic acid metabolism, myonuclear degeneration and the ...
Machado PM, Dimachkie MM, Barohn RJ.
europepmc   +4 more sources

CYLD dysregulation in pathogenesis of sporadic inclusion body myositis. [PDF]

Sci Rep, 2019
AbstractSporadic inclusion body myositis (sIBM) is the most commonly acquired myopathy in middle-aged and elderly people. The muscle histology is characterized by both inflammation and degeneration, including sarcoplasmic aggregation of TDP-43. Cylindromatosis (CYLD) is a deubiquitinating enzyme that targets Lys63-linked ubiquitin chains and negatively
Yamashita S, Matsuo Y, Tawara N, Hara K, Yamamoto M, Nishikami T, Kawakami K, Zhang X, Zhang Z, Doki T, Ando Y.   +10 more
europepmc   +4 more sources

Dysphagia in Patients with Sporadic Inclusion Body Myositis: Management Challenges [PDF]

International Journal of General Medicine, 2019
Nika Mohannak,1 Gemma Pattison,2 Kathryn Hird,1 Merrilee Needham1,3,4 1School of Medicine, The University of Notre Dame, Fremantle, Western Australia, Australia; 2Department of Speech Pathology, Royal Perth Hospital, Perth, Western Australia, Australia ...
Mohannak N, Pattison G, Hird K, Needham M   +3 more
doaj   +2 more sources

Proteomic study of sporadic inclusion body myositis. [PDF]

Proteome Sci, 2014
Sporadic inclusion body myositis (s-IBM) is the most commonly occurring acquired inflammatory myopathy in elderly people (>45 years); however, pathogenic mechanisms are poorly understood and diagnostic tools are limited. In view of this, new therapeutic and diagnostic molecular markers for s-IBM need to be identified.In this study, the proteomes from ...
Li K, Pu C, Huang X, Liu J, Mao Y, Lu X.
europepmc   +4 more sources

Proteomic Profiling Unravels a Key Role of Specific Macrophage Subtypes in Sporadic Inclusion Body Myositis [PDF]

Frontiers in Immunology, 2019
Unbiased proteomic profiling was performed toward the identification of biological parameters relevant in sIBM, thus giving hints about the pathophysiological processes and the existence of new reliable markers. For that purpose, skeletal muscle biopsies
Andreas Roos, Andreas Roos, Corinna Preusse, Denisa Hathazi, Hans-Hilmar Goebel, Werner Stenzel, Werner Stenzel   +6 more
doaj   +2 more sources

Targeting protein homeostasis in sporadic inclusion body myositis. [PDF]

Sci Transl Med, 2016
Augmenting the heat shock response with arimoclomol ameliorates pathology in cellular and animal models of inclusion body myositis.
Ahmed M, Machado PM, Miller A, Spicer C, Herbelin L, He J, Noel J, Wang Y, McVey AL, Pasnoor M, Gallagher P, Statland J, Lu CH, Kalmar B, Brady S, Sethi H, Samandouras G, Parton M, Holton JL, Weston A, Collinson L, Taylor JP, Schiavo G, Hanna MG, Barohn RJ, Dimachkie MM, Greensmith L.   +26 more
europepmc   +6 more sources

The immune system in sporadic inclusion body myositis patients is not compromised by blood-flow restricted exercise training [PDF]

Arthritis Research & Therapy, 2019
Background Sporadic inclusion body myositis (sIBM) is clinically characterised by progressive proximal and distal muscle weakness and impaired physical function while skeletal muscle tissue displays abnormal cellular infiltration of T cells, macrophages,
Kasper Yde Jensen, Mikkel Jacobsen, Henrik Daa Schrøder, Per Aagaard, Jakob Lindberg Nielsen, Anders Nørkær Jørgensen, Eleanor Boyle, Rune Dueholm Bech, Sofie Rosmark, Louise Pyndt Diederichsen, Ulrik Frandsen   +10 more
doaj   +2 more sources

Mitochondrial and inflammatory changes in sporadic inclusion body myositis. [PDF]

Neuropathol Appl Neurobiol, 2015
AimsSporadic inclusion body myositis (sIBM) is the most common late onset muscle disease causing progressive weakness. In light of the lack of effective treatment, we investigated potential causes underlying muscle wasting. We hypothesized that accumulation of mitochondrial respiratory deficiency in muscle fibres may lead to fibre atrophy and ...
Rygiel KA, Miller J, Grady JP, Rocha MC, Taylor RW, Turnbull DM.   +5 more
europepmc   +5 more sources