Kinetics of Mosquito-Injected Plasmodium Sporozoites in Mice: Fewer Sporozoites Are Injected into Sporozoite-Immunized Mice [PDF]
PLoS Pathogens, 2009 Malaria is initiated when the mosquito introduces sporozoites into the skin of a mammalian host. To successfully continue the infection, sporozoites must invade blood vessels in the dermis and be transported to the liver.
Chahnaz Kebaier +2 more
exaly +5 more sources
Exit of Plasmodium Sporozoites from Oocysts Is an Active Process That Involves the Circumsporozoite Protein [PDF]
PLoS Pathogens, 2005 Plasmodium sporozoites develop within oocysts residing in the mosquito midgut. Mature sporozoites exit the oocysts, enter the hemolymph, and invade the salivary glands.
Hisashi Fujioka, VÍCTOR Nussenzweig
exaly +3 more sources
In vitro inhibitory activities of sugarcane extract on avian Eimeria sporozoites
International Journal for Parasitology: Drugs and Drug Resistance, 2021 The current in vitro study aimed to investigate the effects of a processed sugarcane extract on the viability of avian Eimeria sporozoites. Treatments were applied to hatched sporozoites: 1) without additives (no-treatment control); 2) with ethanol; 3 ...
Matthew Flavel +2 more
exaly +3 more sources
EMBO Molecular Medicine, 2021 Malaria infection starts with the injection of Plasmodium sporozoites into the host’s skin. Sporozoites are motile and move in the skin to find and enter blood vessels to be carried to the liver.
Haiyun Liu +2 more
exaly +2 more sources
Plasmodium berghei rhoptry neck protein 6 maintains parasite infectivity and virulence [PDF]
mBioApicomplexan parasites possess unique secretory organelles called rhoptries, which are reservoirs for rhoptry neck proteins (RONs) and rhoptry bulb proteins (ROPs) that aid in host cell attachment, invasion, and intracellular proliferation. In Plasmodium
Veeda Narahari +6 more
doaj +2 more sources
Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission. [PDF]
SmallEngineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Sivakumaran N +10 more
europepmc +2 more sources
Veterinary Sciences, 2022 Coccidiosis is one of the most common infectious diseases that causes digestive problems in rabbits, leading to global economic losses. This study was conducted to evaluate the effects of bile obtained from sheep gallbladder on the sporulation and ...
Mutee Murshed +2 more
doaj +1 more source
New Avenues to Design Toxoplasma Vaccines Based on Oocysts and Cysts
Frontiers in Immunology, 2022 Toxoplasmosis is a worldwide disease affecting all warm-blooded animals, including humans. Vaccination strategies aimed at inducing an efficient immune response while preventing transmission have been attempted in the past.
David Arranz-Solís, Jeroen P. J. Saeij
doaj +1 more source
Innate immunity to malaria: The good, the bad and the unknown
Frontiers in Immunology, 2022 Malaria is the cause of 600.000 deaths annually. However, these deaths represent only a tiny fraction of total malaria cases. Repeated natural infections with the causative agent, Plasmodium sp.
Kai Pohl, Kai Pohl, Ian A. Cockburn
doaj +1 more source
Experimental evaluation of cryopreservative solutions to maintain in vitro and in vivo infectivity of P. berghei sporozoites. [PDF]
PLoS ONE, 2017 The rodent malaria parasite Plasmodium berghei is an excellent model organism for laboratory-based experimental evaluation of anti-malarial therapeutics prior to studies with human malaria parasites.
Naresh Singh +3 more
doaj +1 more source