Results 31 to 40 of about 12,830 (178)

In vitro: Anti-coccidia activity of Calotropis procera leaf extract on Eimeria papillata oocysts sporulation and sporozoite

Open Chemistry, 2022
Natural products play an important role as environmentally friendly agents that can be used against parasitic diseases. Many Eimeria species cause eimeriosis in poultry. The negative effects of synthetic anti-coccidiosis medications necessitate the quest
Murshed Mutee, Al-Quraishy Saleh, Qasem Mahmood A.   +2 more
doaj   +1 more source

Infectivity of Symptomatic Patients and Their Contribution for Infectiousness of Mosquitoes following a Membrane Feeding Assay in Ethiopia

Microbiology Spectrum, 2022
The membrane feeding assay is widely used to evaluate the efficacy of transmission-blocking interventions (TBIs) and identify the reservoir of malaria.
Andargie Abate, Soriya Kedir, Mitiku Bose, Jifar Hassen, Laurent Dembele, Lemu Golassa   +5 more
doaj   +1 more source

Plasmodium yoelii-infected A. stephensi inefficiently transmit malaria compared to intravenous route. [PDF]

PLoS ONE, 2010
It was recently reported that when mosquitoes infected with P. berghei sporozoites feed on mice, they deposit approximately 100-300 sporozoites in the dermis. When we inoculate P.
Solomon Conteh, Rana Chattopadhyay, Charles Anderson, Stephen L Hoffman   +3 more
doaj   +1 more source

Plasmodium Sporozoite Biology [PDF]

Cold Spring Harbor Perspectives in Medicine, 2017
Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of a candidate antisporozoite subunit vaccine formulation to licensure highlights the importance of sporozoite transmission intervention in the malaria control portfolio.
Friedrich, Frischknecht, Kai, Matuschewski   +1 more
openaire   +2 more sources

Killing of Plasmodium Sporozoites by Basic Amphipathic α-Helical Fusion Peptides

Microorganisms
Membranolytic molecules constitute the first line of innate immune defense against pathogenic microorganisms. Plasmodium sporozoites are potentially exposed to these cytotoxic molecules in the hemolymph and salivary glands of mosquitoes, as well as in ...
Manuela C. Aguirre-Botero, Eduardo Aliprandini, Anisha Gladston, Olga Pacios, Rafael Miyazawa Martins, Jean-Luc Poyet, Rogerio Amino   +6 more
doaj   +1 more source

Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite

Frontiers in Immunology, 2022
The complement system is considered the first line of defense against pathogens. Hijacking complement regulators from blood is a common evasion tactic of pathogens to inhibit complement activation on their surfaces.
Ayman Khattab, Ayman Khattab, Mikel Rezola, Marta Barroso, Mikael Kyrklund, Mikael Kyrklund, Tero Pihlajamaa, Tobias L. Freitag, Geert-Jan van Gemert, Teun Bousema, Perttu Permi, Perttu Permi, Ossi Turunen, Ossi Turunen, Robert Sauerwein, Adrian J. F. Luty, Seppo Meri, Seppo Meri, Seppo Meri   +18 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Killing of Cryptosporidium sporozoites by Lactoferrin [PDF]

The American Journal of Tropical Medicine and Hygiene, 2017
Intestinal infection caused by Cryptosporidium is a major contributor to diarrhea morbidity and mortality in young children around the world. Current treatments for children suffering from cryptosporidiosis are suboptimal. Lactoferrin is a glycoprotein found in breast milk.
Paredes, Jose Luis, Sparks, Hayley, White, A. Clinton, Martinez-Traverso, Griselle, Ochoa Woodell, Theresa Jean, Castellanos-González, Alejandro   +5 more
openaire   +3 more sources

Long‐term impact of exposure to Royal Guard, a pyriproxyfen‐based bed net, on pyrethroid‐resistant malaria vectors from Cameroon using DNA‐based metabolic resistance markers

Pest Management Science, Volume 81, Issue 4, Page 2165-2180, April 2025.
We used recently detected P450 DNA‐based markers of pyrethroid resistance in both Anopheles funestus and Anopheles gambiae to demonstrate that although pyrethroid‐resistant mosquitoes have higher ability to survive and live longer after exposure to Royal Guard, this net significantly affects their lifespan, blood feeding ability and interestingly ...
Emilie S Ngongang‐Yipmo, Magellan Tchouakui, Benjamin D Menze, Riccado F Tiomela, Derrick Fofie, Vanessa B Ngannang‐Fezeu, Jean L Mugenzi, Flobert Njiokou, Charles S Wondji   +8 more
wiley   +1 more source

Effects of Vector Density on Blood Parasite Spread and Health Consequences for Avian Hosts: An Experimental Epidemiology Blueprint

Integrative Zoology, EarlyView.
In an experimental epidemiology setup, groups of pigeons were exposed to different numbers of infective malaria vectors. Vector number explained the speed of transmission, the final prevalence, and changes in host behavior. ABSTRACT Vector density plays a critical role in the transmission dynamics of vector‐borne diseases and thus in their health and ...
Nayden Chakarov, Tim Brandler, Kai Fischer, Carmen Schwietz   +3 more
wiley   +1 more source