Results 51 to 60 of about 18,335 (219)
Transgenic selection and underlying mechanisms in apicomplexan parasites
The FEBS Journal, EarlyView.Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju +2 more
wiley +1 more source
Nutrient Sensing and Growth Control in Plasmodium: Beyond mTOR Signaling
Molecular Microbiology, EarlyView.Plasmodium parasites lack the canonical mTOR kinase and associated signaling complexes, yet retain key mTOR‐like functions. Parasite‐specific nutrient sensors, kinases, and translational regulators coordinate growth, stress adaptation, metabolic plasticity, and developmental decisions through a distributed regulatory network.
Felix Müller, Gabriele Pradel
wiley +1 more source
SCID foal infection with cryopreserved sporozoites.
, 2013 Course of parasitemia for SCID foals infected with sporozoites by intravenous inoculation. SCID1 = 4×106; SCID2 = 6×106 sporozoites.
Joshua D. Ramsay (467514) +5 more
core +1 more source
COMMON EPITOPES ON EIMERIA-TENELLA SPOROZOITES AND CECAL EPITHELIUM OF CHICKENS [PDF]
, 1993 Eimeria tenella sporozoites invade the intestinal epithelium at a highly specific site. Certain molecules that were recognized by monoclonal antibody E.TEN 11M-2, which was prepared against E.
VERVELDE, L +2 more
core +2 more sources
Medical and Veterinary Entomology, EarlyView.Densities of all Anopheles species were approximately comparable across all IRS regimes. No differences observed between treatment regimes regarding species composition of the Anopheles funestus group or An. gambiae complex. This operational pilot demonstrates the practical feasibility of IRS micro‐mosaics, despite the inherent increase in deployment ...
Dingani Chinula +9 more
wiley +1 more source
Plasmodium falciparum: Release of circumsporozoite protein by sporozoites in the mosquito vector [PDF]
, 1992 The release of circumsporozoite (CS) protein by Plasmodium falciparum sporozoites was investigated to identify factors regulating this process within infected Anopheles gambiae mosquitoes.
Vaughan, Jefferson A. +6 more
core +2 more sources
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
Frontiers in Microbiology, 2019 The relationship between Plasmodium falciparum gametocyte density and infections in mosquitoes is central to understanding the rates of transmission with important implications for control.
Ashutosh K. Pathak +10 more
doaj +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Killing of Cryptosporidium sporozoites by Lactoferrin [PDF]
The American Journal of Tropical Medicine and Hygiene, 2017 Intestinal infection caused by Cryptosporidium is a major contributor to diarrhea morbidity and mortality in young children around the world. Current treatments for children suffering from cryptosporidiosis are suboptimal. Lactoferrin is a glycoprotein found in breast milk.
Paredes, Jose Luis +5 more
openaire +3 more sources