Results 51 to 60 of about 12,830 (178)

Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites

Scientific Reports, 2021
In the malaria-causing parasite’s life cycle, Plasmodium sporozoites must travel from the midgut of a mosquito to the salivary glands before they can infect a mammalian host. However, only a fraction of sporozoites complete the journey.
Anthony A. Ruberto, Caitlin Bourke, Nicolas Merienne, Thomas Obadia, Rogerio Amino, Ivo Mueller   +5 more
doaj   +1 more source

Metal–Drug Complexes as Long‐Release Application for Antimalarial PfFNT‐Inhibitors

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
P. falciparum formate‐nitrite transporter (PfFNT) inhibitors have emerged as a novel antimalarial class with potent in vivo and liver‐stage activity. Low‐solubility metal–inhibitor complexes were prepared as potential long‐acting injectables.
Finn Tiedjens, Björn Henke, Ulrich Girreser, Regina Scherließ, Eric Beitz   +4 more
wiley   +1 more source

Disruption of Plasmodium Sporozoite Transmission by Depletion of Sporozoite Invasion-Associated Protein 1 [PDF]

Eukaryotic Cell, 2009
ABSTRACT Accumulation of infectious Plasmodium sporozoites in Anopheles spp. salivary glands marks the final step of the complex development of the malaria parasite in the insect vector.
Engelmann, S., Silvie, O., Matuschewski, K.   +2 more
openaire   +3 more sources

Hit‐To‐Lead Optimization of a Pyridylpiperazine Class Against Malaria: Pharmacokinetic Profile and In Vivo Efficacy of Optimized Compounds

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira, Duarte Eduardo Pereira, Rafael Consolin Chelucci, Simone Michelan, Júlia Maria Fernandes Pituba, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Neide Maria Silva, Celso de Oliveira Rezende Júnior   +8 more
wiley   +1 more source

Plasmodium sporozoite motility: an update

Frontiers in Bioscience, 2012
Plasmodium, the causative agent of malaria, employs its own actin/myosin-based motor for forward locomotion, penetration of molecular and cellular barriers, and invasion of target cells. The sporozoite is unique amongst the extracellular Plasmodium developmental forms in that it has to cross considerable distances and different tissues inside the ...
Montagna, Georgina Nuri, Matuschewski, Kai, Buscaglia, Carlos Andres   +2 more
openaire   +5 more sources

CD8+ Tissue‐Resident Memory T Cells in Health and Disease

MedComm, Volume 7, Issue 7, July 2026.
CD8+ TRM cells are at the center of immunity, mediating potent local innate and adaptive immune responses. While TRM cells mediate protective immunity against infections and tumors, they also contribute to pathological inflammation in autoimmune conditions.
Yu‐Han Ai, Ting‐Ting Xu, Sen Lin, Meng‐Yu Xiao, Yun‐Xia Lin, Hao‐Wen Ma, Yue‐Yang Liu, Yao‐Jie Wang, Lu‐Ning Yin, Mei Huang, Yong‐Da Liu, Chao Zhu, Xiao‐Ting Zhu, Ji‐Hang Yuan   +13 more
wiley   +1 more source

Challenging the Clinical Paradigm of Hepatozoon canis: A Primary Pathogen Causing Clinically Significant Disease at Low Parasitaemia and a Chronic Inflammatory State

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Hepatozoon canis causes significant clinical disease even at low parasitaemia and induces chronic subclinical anaemia and inflammation in dogs. Lack of tick control is the main modifiable risk factor. Molecular diagnosis is far more sensitive than microscopy, challenging the traditional view that disease severity depends solely on parasite burden ...
Somayeh Bahrami, Zahra Mashayekhi, Seyedeh Misagh Jalali, Mohammad Khosravi, Mohammad Rajabloo   +4 more
wiley   +1 more source

Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice

Cell Reports, 2017
Malaria sporozoites are deposited into the skin by mosquitoes and infect hepatocytes. The molecular basis of how Plasmodium falciparum sporozoites migrate through host cells is poorly understood, and direct evidence of its importance in vivo is lacking ...
Annie S.P. Yang, Matthew T. O’Neill, Charlie Jennison, Sash Lopaticki, Cody C. Allison, Jennifer S. Armistead, Sara M. Erickson, Kelly L. Rogers, Andrew M. Ellisdon, James C. Whisstock, Rebecca E. Tweedell, Rhoel R. Dinglasan, Donna N. Douglas, Norman M. Kneteman, Justin A. Boddey   +14 more
doaj   +1 more source

Single‐Cell Transcriptomics and Development of Gametocyte‐Specific Molecular Markers for Avian Malaria Parasites

Molecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Avian malaria, caused by Plasmodium parasites, poses a significant threat to bird populations worldwide, particularly in vulnerable island ecosystems. Yet, progress in understanding avian malaria transmission dynamics has been hampered by the lack of molecular tools to quantify and sex the transmissible stages of the parasite: the male and ...
A. Berthomieu, I. Rizos, J. W. Bagnoli, S. Gandon, A. M. Talman, A. Rivero   +5 more
wiley   +1 more source

Morphological and Molecular Characterization of Eimeria saudiensis From Arabian Oryx (Oryx leucoryx) Held in Captivity in the Sultanate of Oman 阿曼苏丹国圈养阿拉伯羚羊 (Oryx leucoryx) 体内沙特艾美球虫 (Eimeria saudiensis) 的形态学与分子特征

Wildlife Letters, Volume 4, Issue 2, Page 73-82, June 2026.
Eimeria saudiensis represents a genus of apicomplexan parasites capable of inducing coccidiosis in Arabian oryx. Our research concentrated on the morphological and molecular investigation of Eimeria spp. in the captive oryx herd in Oman. The therapeutic and management practices employed at the Mammals Breeding Center were reassessed to diminish ...
Khalid Al‐Habsi, Elshafie I. Elshafie, Kaadhia Al‐Kharousi, Haytham Ali, Abeer Al‐Hamrashdi, Barbara Golachowska, Masoud Al‐Aufi, Eugene H. Johnson   +7 more
wiley   +1 more source