Results 71 to 80 of about 14,501 (156)

Variation in relapse frequency and the transmission potential of Plasmodium vivax malaria [PDF]

, 2016
There is substantial variation in the relapse frequency of Plasmodium vivax malaria, with fast-relapsing strains in tropical areas, and slow-relapsing strains in temperate areas with seasonal ...
Ghani, A, Karl, S, Mueller, I, Shirreff, G, White, MT   +4 more
core   +4 more sources

Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission [PDF]

, 2020
Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear.
Abel, Steven, Batugedara, Gayani, Bottrill, Andrew R., Boucher, Matthew, Brady, Declan, Daniel, Emilie, Freville, Aline, Gupta, Dinesh, Holder, Anthony A., Hollin, Thomas, Le Roch, Karine G., Lu, Xueqing Maggie, Pandey, Rajan, Rea, Edward, Stanway, Rebecca R., Tewari, Rita, Wall, Richard J., Wheatley, Sally, Zeeshan, Mohammad   +18 more
core   +3 more sources

Disruption of Plasmodium Sporozoite Transmission by Depletion of Sporozoite Invasion-Associated Protein 1 [PDF]

Eukaryotic Cell, 2009
ABSTRACT Accumulation of infectious Plasmodium sporozoites in Anopheles spp. salivary glands marks the final step of the complex development of the malaria parasite in the insect vector.
Engelmann, S., Silvie, O., Matuschewski, K.   +2 more
openaire   +3 more sources

Simulated Microgravity Causes Faster Replication During Acute Infection of ME49‐Toxoplasma Gondii and Alterations in Host Cells

FASEB BioAdvances, Volume 8, Issue 4, April 2026.
Simulated microgravity (SMG) alters the growth and morphology of host cells and induces parasite replication during acute T. gondii infection. In this study, we examined host cells and Type II T. gondii using a 3D clinostat. Increased number of host cells and multicellular spheroids observed in Vero cells and HFF.
Musfika Tasnim Shirin, Takafumi Yamada, Iqra Zafar, Daisuke Kondoh, Hiroki Bochimoto, Hironori Bando, Oluyomi Stephen Adeyemi, Yasuhiro Fukuda, Kentaro Kato   +8 more
wiley   +1 more source

Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccine antigens using chimeric rodent parasites.

PLoS ONE, 2021
To screen for additional vaccine candidate antigens of Plasmodium pre-erythrocytic stages, fourteen P. falciparum proteins were selected based on expression in sporozoites or their role in establishment of hepatocyte infection. For preclinical evaluation
Surendra Kumar Kolli, Ahmed M Salman, Jai Ramesar, Severine Chevalley-Maurel, Hans Kroeze, Fiona G A Geurten, Shinya Miyazaki, Ekta Mukhopadhyay, Catherin Marin-Mogollon, Blandine Franke-Fayard, Adrian V S Hill, Chris J Janse   +11 more
doaj   +1 more source

Genetic Surveillance Reveals Differential Evolutionary Dynamic of Anopheles gambiae Under Contrasting Insecticidal Tools Used in Malaria Control

Molecular Ecology, Volume 35, Issue 5, March 2026.
ABSTRACT Malaria, a febrile disease caused by the Plasmodium parasites and transmitted by mosquitoes, is a leading cause of mortality in children under 5 in endemic countries. The widespread deployment of insecticide‐treated bed nets (ITNs) has significantly reduced malaria transmission, but rising levels of insecticide resistance threaten to halt the ...
Harun N. Njoroge, Lilian Namuli, Sanjay C. Nagi, Anastasia Hernandez‐Koutoucheva, Daniel P. McDermott, Erin Knight, Samuel Gonahasa, Amy Lynd, Ambrose Oruni, Catherine Maiteki‐Sebuguzi, Jimmy Opigo, Adoke Yeka, Agaba Katureebe, Mary Kyohere, Moses R. Kamya, Grant Dorsey, Janet Hemingway, Sarah G. Staedke, Chris Clarkson, Alistair Miles, Eric R. Lucas, Martin J. Donnelly   +21 more
wiley   +1 more source

Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites

Scientific Reports, 2021
In the malaria-causing parasite’s life cycle, Plasmodium sporozoites must travel from the midgut of a mosquito to the salivary glands before they can infect a mammalian host. However, only a fraction of sporozoites complete the journey.
Anthony A. Ruberto, Caitlin Bourke, Nicolas Merienne, Thomas Obadia, Rogerio Amino, Ivo Mueller   +5 more
doaj   +1 more source

Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite

Traffic, Volume 27, Issue 1, March 2026.
This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light chain, and AP‐1 γ subunit were found associated with certain proteins known to be involved in cytostome function, and they were localized at the collars of ...
Jun Miao, Amuza Byaruhanga Lucky, Gang Ning, Xian Xia, Xiaoying Liang, Faiza Siddiqui, Hui Min, Chengqi Wang, Xiaolian Li, Z. Hong Zhou, Liwang Cui   +10 more
wiley   +1 more source

Defining stage-specific activity of potent new inhibitors of Cryptosporidium parvum growth in vitro [PDF]

, 2020
Currently, nitazoxanide is the only FDA-approved treatment for cryptosporidiosis; unfortunately, it is ineffective in immunocompromised patients, has varied efficacy in immunocompetent individuals, and is not approved in infants under 1 year of age ...
Funkhouser-Jones, Lisa J, Ravindran, Soumya, Sibley, L. David   +2 more
core   +2 more sources

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, Volume 36, Issue 11, 5 February 2026.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source