Results 61 to 70 of about 18,335 (219)

Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccine antigens using chimeric rodent parasites.

PLoS ONE, 2021
To screen for additional vaccine candidate antigens of Plasmodium pre-erythrocytic stages, fourteen P. falciparum proteins were selected based on expression in sporozoites or their role in establishment of hepatocyte infection. For preclinical evaluation
Surendra Kumar Kolli, Ahmed M Salman, Jai Ramesar, Severine Chevalley-Maurel, Hans Kroeze, Fiona G A Geurten, Shinya Miyazaki, Ekta Mukhopadhyay, Catherin Marin-Mogollon, Blandine Franke-Fayard, Adrian V S Hill, Chris J Janse   +11 more
doaj   +1 more source

Computational Optimisation of EtAMA1 Reveals Its Potential as a Vaccine Candidate Against Eimeria tenella

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Eimeria tenella is one of the main causes of coccidiosis in poultry, with increasing drug resistance highlighting the need for alternate control strategies. This study identified Eimeria tenella AMA1 (EtAMA1) as a promising vaccine candidate through structural analysis, epitope prediction, immune simulation, and molecular docking, which demonstrated ...
Nooran Mahomed Rafeer, Victoria Teniola Adeleke, Matthew Adekunle Adeleke   +2 more
wiley   +1 more source

Trained Immunity in Childhood Vaccination

Acta Paediatrica, Volume 115, Issue 11, Page 2402-2413, November 2026.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source

Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites

Scientific Reports, 2021
In the malaria-causing parasite’s life cycle, Plasmodium sporozoites must travel from the midgut of a mosquito to the salivary glands before they can infect a mammalian host. However, only a fraction of sporozoites complete the journey.
Anthony A. Ruberto, Caitlin Bourke, Nicolas Merienne, Thomas Obadia, Rogerio Amino, Ivo Mueller   +5 more
doaj   +1 more source

A Genetically Encoded Marker for Imaging of Internal Plasmodium Membranes

Molecular Microbiology, Volume 126, Issue 4, Page 462-472, October 2026.
IMMP is a peptide‐based marker that labels internal membranes across multiple stages and species of the malaria‐causing parasite Plasmodium. It works in both live and fixed samples and supports long‐term live‐cell imaging. ABSTRACT Fluorescence microscopy is a powerful tool to analyze the subcellular architecture, and long‐term live‐cell imaging ...
Leah Zink, Viola Reuschenbach, Samy Sid Ahmed, Muriel Lauer, Jana Niethammer, Aistė Kudulytė, Katharina Zorko, Oliver T. Fackler, Franziska Hentzschel, Markus Ganter   +9 more
wiley   +1 more source

Malaria Sporozoites Traverse Host Cells within Transient Vacuoles [PDF]

, 2015
International audiencePlasmodium sporozoites are deposited in the host skin by Anopheles mosquitoes. The parasites migrate from the dermis to the liver, where they invade hepatocytes through a moving junction (MJ) to form a replicative parasitophorous ...
Marinach, Carine, Bigorgne, Amélie e., Baudin, Xavier, Lebrun, Maryse, Dubremetz, Jean-François, Manzoni, Giulia, Silvie, Olivier, Topçu, Selma, Risco-Castillo, Veronica, Briquet, Sylvie   +9 more
core   +1 more source

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, Volume 126, Issue 4, Page 412-432, October 2026.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

Disruption of Plasmodium Sporozoite Transmission by Depletion of Sporozoite Invasion-Associated Protein 1 [PDF]

Eukaryotic Cell, 2009
ABSTRACT Accumulation of infectious Plasmodium sporozoites in Anopheles spp. salivary glands marks the final step of the complex development of the malaria parasite in the insect vector.
Engelmann, S., Silvie, O., Matuschewski, K.   +2 more
openaire   +3 more sources

Transgenic Plasmodium berghei sporozoites expressing β-galactosidase for quantification of sporozoite transmission [PDF]

Molecular and Biochemical Parasitology, 2006
Malaria transmission occurs during a blood-meal of an infected Anopheles mosquito. Visualization and quantification of sporozoites along the journey from the mosquito midgut, where they develop, to the vertebrate liver, their final target organ, is important for understanding many aspects of sporozoite biology.
Sabine, Engelmann, Photini, Sinnis, Kai, Matuschewski   +2 more
openaire   +2 more sources

Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice

Cell Reports, 2017
Malaria sporozoites are deposited into the skin by mosquitoes and infect hepatocytes. The molecular basis of how Plasmodium falciparum sporozoites migrate through host cells is poorly understood, and direct evidence of its importance in vivo is lacking ...
Annie S.P. Yang, Matthew T. O’Neill, Charlie Jennison, Sash Lopaticki, Cody C. Allison, Jennifer S. Armistead, Sara M. Erickson, Kelly L. Rogers, Andrew M. Ellisdon, James C. Whisstock, Rebecca E. Tweedell, Rhoel R. Dinglasan, Donna N. Douglas, Norman M. Kneteman, Justin A. Boddey   +14 more
doaj   +1 more source