Results 41 to 50 of about 18,335 (219)

Plasmodium yoelii-infected A. stephensi inefficiently transmit malaria compared to intravenous route. [PDF]

PLoS ONE, 2010
It was recently reported that when mosquitoes infected with P. berghei sporozoites feed on mice, they deposit approximately 100-300 sporozoites in the dermis. When we inoculate P.
Solomon Conteh, Rana Chattopadhyay, Charles Anderson, Stephen L Hoffman   +3 more
doaj   +1 more source

Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite

Frontiers in Immunology, 2022
The complement system is considered the first line of defense against pathogens. Hijacking complement regulators from blood is a common evasion tactic of pathogens to inhibit complement activation on their surfaces.
Ayman Khattab, Ayman Khattab, Mikel Rezola, Marta Barroso, Mikael Kyrklund, Mikael Kyrklund, Tero Pihlajamaa, Tobias L. Freitag, Geert-Jan van Gemert, Teun Bousema, Perttu Permi, Perttu Permi, Ossi Turunen, Ossi Turunen, Robert Sauerwein, Adrian J. F. Luty, Seppo Meri, Seppo Meri, Seppo Meri   +18 more
doaj   +1 more source

Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells. [PDF]

, 2005
Contains fulltext : 47790schaijk.pdf (Publisher’s version ) (Closed access)Immunization with Plasmodium sporozoites that have been attenuated by gamma-irradiation or specific genetic modification can induce protective immunity against ...
Sauerwein, Robert W, Douradinha, B.G., van Dooren, Maaike W, Geert-Jan van Gemert, Volker Heussler, Schaijk, B.C.L. van, Andrew P. Waters, Sauerwein, R.W., Robert W. Sauerwein, Mota, Maria M, Gemert, G.J.A. van, Waters, A.P., van Dijk, Melissa R, Bruno Douradinha, Maria M. Mota, van Schaijk, Ben, Maaike W. van Dooren, Blandine Franke-Fayard, Douradinha, Bruno, Chris J. Janse, van Gemert, Geert-Jan, Dijk, M.R. van, Janse, Chris J, Mota, M.M., Janse, C.J., Melissa R. van Dijk, Heussler, Volker, Waters, Andrew P, Heussler, V., Dooren, M.W. van, Ben van Schaijk, Franke-Fayard, Blandine, Franke-Fayard, B.   +32 more
core   +1 more source

Killing of Plasmodium Sporozoites by Basic Amphipathic α-Helical Fusion Peptides

Microorganisms
Membranolytic molecules constitute the first line of innate immune defense against pathogenic microorganisms. Plasmodium sporozoites are potentially exposed to these cytotoxic molecules in the hemolymph and salivary glands of mosquitoes, as well as in ...
Manuela C. Aguirre-Botero, Eduardo Aliprandini, Anisha Gladston, Olga Pacios, Rafael Miyazawa Martins, Jean-Luc Poyet, Rogerio Amino   +6 more
doaj   +1 more source

Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites.

, 2006
Protective immune responses against malaria are induced by immunization with radiation-attenuated Plasmodium sporozoites. In contrast, non-viable, heat-killed sporozoites do not induce protection, emphasizing the requirement for live parasites to achieve
Morrot, Alexandre, Rai, Urvashi, Alexandre Morrot, Fidel Zavala, Hafalla, Julius CR, Rodriguez, Ana, Ana Rodriguez, Zavala, Fidel, Urvashi Rai, Dabeiba Bernal-Rubio, Bernal-Rubio, Dabeiba, Julius C. R. Hafalla   +11 more
core   +1 more source

Migration of Plasmodium sporozoites through cells before infection.

, 2001
Intracellular bacteria and parasites typically invade host cells through the formation of an internalization vacuole around the invading pathogen. Plasmodium sporozoites, the infective stage of the malaria parasite transmitted by mosquitoes, have an ...
Vanderberg, JP, Mota, MM, Rodríguez, A, Nussenzweig, V, Pradel, G, Hafalla, JC, Frevert, U, Nussenzweig, RS   +7 more
core   +1 more source

Effects of Vector Density on Blood Parasite Spread and Health Consequences for Avian Hosts: An Experimental Epidemiology Blueprint

Integrative Zoology, EarlyView.
In an experimental epidemiology setup, groups of pigeons were exposed to different numbers of infective malaria vectors. Vector number explained the speed of transmission, the final prevalence, and changes in host behavior. ABSTRACT Vector density plays a critical role in the transmission dynamics of vector‐borne diseases and thus in their health and ...
Nayden Chakarov, Tim Brandler, Kai Fischer, Carmen Schwietz   +3 more
wiley   +1 more source

Migration through host cells activates Plasmodium sporozoites for infection.

, 2002
Plasmodium sporozoites, the infective stage of the malaria parasite transmitted by mosquitoes, migrate through several hepatocytes before infecting a final one. Migration through hepatocytes occurs by breaching their plasma membranes, and final infection
Hafalla, Julius CR, Rodriguez, Ana, Ana Rodriguez, Mota, Maria M, Julius C.R. Hafalla, Maria M. Mota   +5 more
core   +1 more source

Urbanization and Vector Species Shape Avian Malaria Prevalence in Mosquitoes

Integrative Zoology, EarlyView.
Avian malaria prevalence was assessed in two mosquito species across urban and peri‐urban habitats. No infections were detected in either species in urban areas, while a 2.53% prevalence was found in the native Culex pipiens from peri‐urban sites, highlighting the influence of urbanization on parasite transmission dynamics.
Paula Parra, Jesús Veiga, Marta Garrigós, Guillermo Panisse, Mario Garrido, Josué Martínez‐de la Puente   +5 more
wiley   +1 more source

Plasmodium Sporozoite Biology [PDF]

Cold Spring Harbor Perspectives in Medicine, 2017
Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of a candidate antisporozoite subunit vaccine formulation to licensure highlights the importance of sporozoite transmission intervention in the malaria control portfolio.
Friedrich, Frischknecht, Kai, Matuschewski   +1 more
openaire   +2 more sources