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Spontaneous Hibernomas in Sprague-Dawley Rats
Toxicologic Pathology, 2009Hibernomas are rare neoplasms originating in brown adipose tissue of humans and other animal species, including laboratory animals. Background incidence values for these tumors in all common strains of laboratory rats are generally accepted as being <0.1%.
Richard H, Bruner +10 more
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Behavioral heterogeneity in Sprague-Dawley rats
Physiology & Behavior, 1992Because of consistent individual differences in animal behavior, it is often difficult to interpret experimental data. We therefore attempted to rank Sprague Dawley rats by a hierarchical ascendant clustering technique using data from avoidance conditioning and open-field testing (scores of exploratory activity before, during, and after an ...
M, Curé, J P, Rolinat
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Intrauterine Expression of Prothrombin in the Sprague-Dawley Rat
Journal of the Society for Gynecologic Investigation, 2002Thrombin appears to underlie myometrial contractions in response to intrauterine bleeding. In a similar fashion, thrombin generated within the uterus in the absence of active bleeding could also produce contractions. These studies sought to determine whether functionally active prothrombin is expressed in the pregnant and nonpregnant rat uterus.
Mark, Phillippe +4 more
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Spontaneous leukaemia in a sprague-dawley rat
Experientia, 1962Description d'un cas de chloroleucemie myeloide chez un rat de souche Sprague-Dawley, presentant quelques modifications peu communes des tubes renaux.
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Disposition of butadiene epoxides in Sprague-Dawley rats
Chemico-Biological Interactions, 19971,2-Epoxybutene (BMO) and diepoxybutane (BDE) are metabolic products of 1,3-butadiene in rodents. Both BMO and BDE are suspect in the development of tumors in rats and mice. To understand the distribution and elimination of these compounds in the absence of the rate-limiting production from butadiene, the pharmacokinetics of BMO and BDE in blood were ...
J L, Valentine +5 more
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Spontaneous endocrine tumors in Sprague-Dawley rats
Journal of Cancer Research and Clinical Oncology, 1979Spontaneous endocrine tumors were found in 81 of 100 Sprague-Dawley rats (42 males and 39 females) which survived for more than 2 years. Most of these tumors were medullary carcinomas of the thyroid, followed by tumors of the anterior pituitary gland, pheochromocytomas and cortical adenomas of the adrenal gland, and islet cell tumors of the pancreas ...
H, Suzuki, U, Mohr, G, Kimmerle
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Toxicity Studies of Epichlorohydrin in Sprague-Dawley Rats
Drug and Chemical Toxicology, 1996Adult male and female Sprague-Dawley rats received epichlorohydrin via gavage in distilled water for 10 consecutive days at dose levels of 3, 7, 19, and 46 mg/kg-day, and for 90 days at dose levels of 1, 5, and 25 mg/kg-day. Epichlorohydrin did not adversely effect mortality, but toxicity, at the higher doses, was evident by: 1) losses in body weight ...
F B, Daniel +3 more
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Immunolocalization of Ghrelin in the Stomach of Sprague‐Dawley Rat
Anatomia, Histologia, Embryologia, 2010With 3 figures and 1 tableSummaryTo investigate the distribution of ghrelin in different regions of stomach in Sprague‐Dawley rat, and attempt to compare with those of humans and other mammalian species in this study, the stomach of rats was divided into five sections, cardia, fundus, greater curvature, lesser curvature and pylorus ...
J, Li +6 more
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Carcinogenic Effects of Diisopropanolnitrosamine in Sprague-Dawley Rats
JNCI: Journal of the National Cancer Institute, 1977The carcinogenic effects of diisopropanolinitrosamine (DIPN) were tested in Sprague-Dawley rats and were then compared with results produced earlier by the same substance in Syrian hamsters. In addition to the similarities, several differences were noted; for example, DIPN caused pancreatic tumors in all the hamsters, but only 1 pancreatic tumor was ...
U, Mohr, G, Reznik, P, Pour
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Polycystic kidney disease in Sprague-Dawley rats
Experimental and Toxicologic Pathology, 2015Polycystic kidney disease (PKD) is a cystic genetic disorder of the kidneys which is typically associated with cystic bile duct dilatation in the liver in humans, and domestic and laboratory animals. In humans, there are two types of PKD, autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD ...
Ahmed, Shoieb, Norimitsu, Shirai
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