Results 271 to 280 of about 908,946 (295)

Ozone uptake in awake Sprague-Dawley rats

Toxicology and Applied Pharmacology, 1987
Knowledge of ozone (O3) uptake in rats in integral to efforts to quantitatively extrapolate animal data to man. We have measured percentage O3 uptake in 30 adult Sprague-Dawley rats exposed, nose only, for 1 hr to 0.3, 0.6, or 1.0 ppm O3. Tidal volume and breathing rate measurements, obtained by plethysmography, were time-matched with changes in ...
M J, Wiester, T B, Williams, M E, King, M G, Ménache, F J, Miller   +4 more
openaire   +2 more sources

The Impact of Hyperuricemia on Pharmacokinetics in Sprague–Dawley Rats

European Journal of Drug Metabolism and Pharmacokinetics
Hyperuricemia (HUA) is a metabolic disease closely associated with hypertension. It can induce liver damage, subsequently affecting drug metabolism. However, its specific impacts and underlying mechanisms remain unclear. Therefore, the pharmacokinetics and cytochrome P450 (CYP450) enzyme activities were investigated.Twelve healthy Sprague-Dawley rats ...
Xiaomeng Pan, Dandan Li, Yujuan Chen, JiaMian Lu, Yakun Yang, Yusong Guo, Dezhi Kong, Wei Guo   +7 more
openaire   +2 more sources

Teratogenicity of 5‐azacytidine in the Sprague‐Dawley rat

Journal of Toxicology and Environmental Health, 1990
5-Azacytidine (5-aza), a chemical that is incorporated into DNA and RNA with consequent alterations in the expression of mammalian genes, was administered to pregnant Sprague-Dawley rats on single days during gestation. Doses of 0.5, 1, and 2 mg/kg were given by intraperitoneal injection on d 9, 10, 11, or 12.
M B, Rosen, H S, House, B M, Francis, N, Chernoff   +3 more
openaire   +2 more sources

Exosomes from dysfunctional chondrocytes affect osteoarthritis in Sprague-Dawley rats through FTO-dependent regulation of PIK3R5 mRNA stability

Bone and Joint Research, 2022
Guohua Lv, Lei Kuang, Haoyu He
exaly  

Incidences and Range of Spontaneous Microscopic Lesions in the Eye of Sprague-Dawley Rats and Han Wistar Rats Used in Toxicity Studies

Toxicologic Pathology, 2021
Emilie Cloup, Vasanthi Mowat
exaly  

Benzocaine-induced Methemoglobinemia in Sprague-Dawley Rats

Anesthesiology, 1986
I, Englebach, J R, Harp
openaire   +2 more sources

Spontaneous Neoplastic Lesions in Aged Sprague-Dawley Rats

Experimental Animals, 2001
N Sumi, K Iwakura
exaly  

Age-related Changes in Thyroid Structure and Function in Sprague-Dawley Rats

Veterinary Pathology, 1992
Ralph Heywood
exaly  

Polysorbate 20 increases oral absorption of digoxin in wild-type Sprague Dawley rats, but not in Sprague Dawley rats

International Journal of Pharmaceutics, 2016
Carsten Uhd Nielsen, René Holm
exaly  

Production of Transgenic Rats Using Young Sprague-Dawley Females Treated with PMSG and hCG

Experimental Animals, 2001
Shinichi Hochi, Masumi Hirabayashi, Kazumi Itô   +2 more
exaly