Results 261 to 270 of about 908,946 (295)
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Normal colon of Sprague-Dawley rats
Anatomy and Embryology, 1992The patterns of expression of the human-tumor-associated antigens, CO17-1A, GA73-3, BR55-2, GICA19-9, CA50 and carcino-embryonic antigen (CEA) were studied in the normal colonic mucosa (the last three also in the serum) of Sprague-Dawley rats. Four immunohistochemically different segments were identified: caecum, ascending colon, transverse colon and ...
J D, Shetye, C A, Rubio, H T, Mellstedt
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Lactational transfer of bisphenol A in Sprague–Dawley rats
Toxicology Letters, 2010Bisphenol A (BPA), an important industrial chemical to which humans are exposed on a daily basis, has long been associated with endocrine disruption in experimental animal models. Such exposures are of concern, particularly during fetal and early neonatal periods, because of greater vulnerability of developing organs to aberrant endocrine signaling ...
Daniel R, Doerge +3 more
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Respiration in Sprague-Dawley Rats During Pregnancy
Inhalation Toxicology, 2006Minute ventilation and tidal volume increase in humans during pregnancy. Little data exists, however, on the respiration in pregnant rats, despite their widespread use as an animal model. Since respiration will affect the pharmacokinetics of volatile compounds and ultimately the dose to the fetus, we conducted a study to evaluate respiration in rats ...
Teresa L, Leavens +5 more
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Carcinogenicity of nitrosoazetidine and tetradeuteronitrosoazetidine in sprague-dawley rats
Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1977Nitrosoazetidine was fed to rats in drinking water at three different concentrations. At 2 mmol (10 mmol total dose) all of the rats died with hepatocellular carcinomas by the 62nd week. This was a greater response than to an equivalent dose of nitrosopyrrolidine. At 0.67 mmol, 6 of 21 rats developed liver tumors, and at 0.17 millimolar 2 of 30 animals
W, Lijinsky, H W, Taylor
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Urinary chemistry of the normal Sprague-Dawley rat
Urological Research, 1993On the basis of metabolic in vivo studies using the adult male Sprague-Dawley rat, we present a comprehensive summary of urine species measurements conducted in our laboratory over the last several years, as well as those present in the literature.
P N, Shevock, S R, Khan, R L, Hackett
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Carcinogenicity of 8-nitroquinoline in Sprague—Dawley rats
Cancer Letters, 19788-Nitroquinoline was added to the semisynthetic diet of outbred Sprague-Dawley rats for 48 weeks. Squamous cell carcinomas of the upper digestive tract (tongue and esophagus), but especially of the forestomach, occurred among the higher concentration groups.
M, Takahashi +5 more
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Spontaneous brain tumours in Sprague-Dawley rats
Food and Chemical Toxicology, 1986Data were collected over a 5-yr period on brain tumours occurring spontaneously among Sprague-Dawley-derived rats in the HRC laboratories. Gliomas, like meningiomas, tended to occur more among males than in females, and in general appeared to be lesions of older rats. Astrocytic tumours of rats were less differentiated than those in man.
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Spontaneous neoplasms in aged sprague-dawley rats
Archives of Toxicology, 1992Incidence of neoplastic lesions in untreated Sprague-Dawley rats (1340 males and 1329 females) used as controls in 17 carcinogenicity studies are tabulated and evaluated. In male rats, the most common neoplasms were benign pheochromocytomas and keratoacanthomas (4.0% in each case) followed by pancreatic islet cell adenomas (3.7%), thyroid ...
M, Chandra, M G, Riley, D E, Johnson
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Developmental Toxicity of Thiodiglycol in Sprague-Dawley Rats
International Journal of Toxicology, 2007Thiodiglycol (TG), a hydrolysis product of sulfur mustard (HD), is a potential contaminant of soil and water at certain military sites. To establish developmental toxicity criteria for TG, an oral developmental toxicity study was conducted in Sprague-Dawley rats.
John T, Houpt +4 more
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Inherited tertiary hypothyroidism in Sprague–Dawley rats
Brain Research, 2007Thyroid hormones (THs) are important in the development and maturation of the central nervous system (CNS). The significant actions of THs during CNS development occur at the time when TH levels are lower than those in the mother and the hypothalamic-thyroid (HPT) axis is not fully functional.
George, Stoica +5 more
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