Results 81 to 90 of about 908,946 (295)

Dietary nucleotides extend the life span in Sprague-Dawley rats

, 2013
To observe the effect of prolonged feeding of dietary nucleotides (NTs), and to clarify the effect of NTs on life extension of Sprague-Dawley rats.
Liang, R., Guo, Q., Wang, S., Zhao, M., Li, Yong, Xu, M., Wang, Junbo, Zhang, Z.   +7 more
core   +1 more source

Group name and diet content of Sprague-Dawley (SD) breed rats.

, 2021
Group name and diet content of Sprague-Dawley (SD) breed rats.
Zhechko Dimitrov (11501971), Unzira Kapysheva (11501974), Elmira Zhaxybayeva (11501965), Zhuldyz Smailova (11501968), Fatima Dikhanbayeva (11501962), Arman Issimov (9904213), Nidhi Bansal (199948)   +6 more
core   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension [PDF]

, 2011
Background: Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed.
Norbert Weissmann, Sydykov, Akylbek, Brandes, Ralf, Schermuly, Ralph T., Hossein A Ghofrani, Janssen, Wiebke, Seeger Werner, Ralf P Brandes, Neil Davie, Dahal, Bhola K., Davie, Neil, Janssen Wiebke, Davie Neil, Ghofrani Hossein A, Seeger, Werner, Cornitescu, Teodora, Brandes Ralf P, Cornitescu Teodora, Kosanovic, Djuro, Kojonazarov, Baktybek, Werner Seeger, Friedrich Grimminger, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Dahal Bhola K, Djuro Kosanovic, Baktybek Kojonazarov, Teodora Cornitescu, Schermuly Ralph T, Sydykov Akylbek, Wiebke Janssen, Grimminger Friedrich, Akylbek Sydykov, Kojonazarov Baktybek, Weissmann Norbert, Himal Luitel, Luitel Himal, Ralph T Schermuly, Luitel, Himal, Weißmann, Norbert, Bhola K Dahal, Kosanovic Djuro   +41 more
core   +2 more sources

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Daidzein ameliorates peripheral neuropathy in Sprague Dawley rats

Frontiers in Pharmacology
Neuropathy is the most common disorder comprising peripheral nerve damage in diabetic patients. Prolonged hyperglycaemia and oxidative stress cause metabolic imbalance and are the key reasons for the development of diabetic neuropathy.
Ankit P. Laddha, Yogesh A. Kulkarni
doaj   +1 more source

Prevalence of hand-induced 22-kHz ultrasonic vocalizations in Sprague-Dawley and Wistar Han rats.

, 2022
Prevalence of hand-induced 22-kHz ultrasonic vocalizations in Sprague-Dawley and Wistar Han rats.
Kimberly Navetta (14141964), Chang-Ning Liu (6260843), Seo-Kyoung Hwang (10431836), Cheryl Tyszkiewicz (11352473), Melissa Dragon (14141961), Rebecca Ferreira (3490868)   +5 more
core   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Splenic Hemangiosarcoma in a Young Sprague-Dawley Rat

Journal of Toxicologic Pathology, 2012
The present report describes a rare case of spontaneous hemangiosarcoma in a nine-week-old male Sprague-Dawley rat. At necropsy, multiple white nodules of various sizes were observed on and within the enlarged spleen and liver and were histopathologically determined to be composed of spindle- to oval-shaped cells that showed invasive growth without ...
Shiraki, Katsuhisa, Ono, Mihoko, Kajikawa, Satoru, Takeuchi, Ayano, Murakami, Yuichi, Oishi, Yuji, Matsumoto, Masahiro   +6 more
openaire   +3 more sources

Hematology, clinical biochemistry, and serum IgE and histamine levels in male Sprague-Dawley (SD) rats.

, 2021
Hematology, clinical biochemistry, and serum IgE and histamine levels in male Sprague-Dawley (SD) rats.
Jangmi Lee (1875595), Seongsung Kwak (11349328), Chang-Hoon Rhee (11349331), Junhyung Kim (1277919), Woo-Chan Son (295963), Won-ho Kang (11349334), Mi-Sun Park (597691), Gi-Hyeok Yang (1310064)   +7 more
core   +1 more source