Results 141 to 150 of about 6,149,998 (228)

Additional file 2 of The impact of spray-induced gene silencing on cereal phyllosphere microbiota

Supplementary Material ...
Sundararajan, Poorva, Ghosh, Samrat, Kelbessa, Bekele Gelena, Whisson, Stephen C., Dubey, Mukesh, Chawade, Aakash, Vetukuri, Ramesh Raju   +6 more
openaire   +1 more source

Modulation of Anaphase‐Promoting Complex Genes Regulates Root‐Knot Nematode Gall Development and Plant Susceptibility

Plant, Cell &Environment, Volume 49, Issue 12, Page 10379-10400, December 2026.
ABSTRACT The anaphase‐promoting complex/cyclosome (APC/C) is a multi‐subunit E3 ubiquitin ligase that regulates cell cycle progression, but its role in plant‐pathogen interactions is poorly understood. Here, we demonstrate that regulation of the ubiquitin–proteasome system, involving APC/C‐associated components, is critical for coordinating host cell ...
Aline Köhn Carneiro, Kércya Maria Simões de Siqueira, La Hoang Anh, Sophie Pagnotta, Danila Cabral do Nascimento, Nubia Barbosa Eloy, Harald Keller, Adriana Silva Hemerly, Janice de Almeida Engler   +8 more
wiley   +1 more source

Rethinking RNAi efficiency: the role of fungal lifestyle in HIGS and SIGS success

New Phytologist, EarlyView.
Gülce Tekin, Emna Arous, Ena Šečić
wiley   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, Volume 13, Issue 61, 3 November 2026.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 2821-2855, November 2026.
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Michael Dare Asemoloye
wiley   +1 more source

Dichloroacetate Improves Animal Survival, Growth, Neuromuscular Activity, Mitochondrial Stress and Physiology, and Elevated Lactate in C. elegans pdha‐1 and dld‐1 RNAi Models of Pyruvate Dehydrogenase Complex Deficiency (PDCD)

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Pyruvate dehydrogenase complex (PDHc) deficiency (PDCD) is a primary mitochondrial disorder characterized by neurodevelopmental disability, altered intermediary metabolism, and early mortality. Dichloroacetate (DCA), a pyruvate analog, activates PDHc and remains under clinical investigation for treatment of PDCD.
Cristina Remes, Neal D. Mathew, Victoria Miranda, Suraiya Haroon, Tyler O'Hara, Vernon E. Anderson, Manuela Lavorato, Kelsey Keith, Rui Xiao, Eiko Nakamaru‐Ogiso, Marni J. Falk   +10 more
wiley   +1 more source

Inhaled Nanomedicines for Lung Diseases and Injuries: Pharmacological Advances and Clinical Translation

MedComm, Volume 7, Issue 11, November 2026.
Graphical overview of bioinspired regenerative platforms designed to remodel the diseased lung microenvironment. These systems integrate gene addition, siRNA‐mediated transcript silencing, CRISPR‐based modulation, and base editing approaches to promote alveolar repair, AT2‐to‐AT1 regeneration, resolution of inflammation, and restoration of vascular ...
Kajal Kamra, Sonal Gaur, Jaswinder Singh
wiley   +1 more source

Alzheimer's Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 11, November 2026.
Alzheimer's disease involves Aβ/tau aggregation, neuroinflammation, BBB leakage, gut–brain dysfunction, and mitochondrial damage, causing neuronal loss. Nanodelivery enables combined small‐molecule and targeted therapies. Disease‐modifying biologics/chemicals, including anti‐Aβ antibodies, raise safety and access concerns. Exercise, cognitive training,
Gaoshuang Fu, Mingmin Pan, Qingling Sun, Guangxin Yue, Tong Lei   +4 more
wiley   +1 more source

Spray-induced gene silencing as a promising tool for sustainable plant protection [PDF]

Triticum aestivum L. (wheat), Hordeum vulgare L. (barley) and Solanum tuberosum (potato) are major crops contributing to primary food production and food security worldwide. However, their cultivation is hampered by pathogens and pests. Existing methods for plant protection largely consist of cultural practices, using fungicides, and breeding for ...
openaire  

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, Volume 82, Issue 11, Page 10604-10614, November 2026.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source