Results 61 to 70 of about 6,149,998 (228)

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Spray-induced gene silencing targeting ZmHSF20 enhances maize thermotolerance

Molecular Breeding
Spray-induced gene silencing (SIGS) is an emerging, time-efficient, and eco-friendly strategy for crop trait manipulation. Heat stress severely threatens global maize production; however, whether SIGS can be effectively applied to improve maize heat tolerance remains largely unexplored.
Zhang, Jie, Zhang, Zichen, Lin, Mingzhou, Dai, Mingqiu, Sun, Xiaopeng, Xiang, Yanli   +5 more
openaire   +2 more sources

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Nanotechnology-enabled dsRNA-based product development for crop protection

Plant Nano Biology
Double-stranded RNA (dsRNA) crop protection is advancing through two distinct product routes: transformative approaches, including host-induced gene silencing (HIGS) and plastid-expressed dsRNA, and non-transformative approaches, including spray-induced ...
Ulhas S. Kadam, Jong Chan Hong
doaj   +1 more source

Concepts and considerations for enhancing RNAi efficiency in phytopathogenic fungi for RNAi-based crop protection using nanocarrier-mediated dsRNA delivery systems

Frontiers in Fungal Biology, 2022
Existing, emerging, and reemerging strains of phytopathogenic fungi pose a significant threat to agricultural productivity globally. This risk is further exacerbated by the lack of resistance source(s) in plants or a breakdown of resistance by pathogens ...
Poonam Ray, Debashish Sahu, Raghavendra Aminedi, Divya Chandran   +3 more
doaj   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Exogenous dsRNA-Induced Silencing of the Phytophthora infestans Elicitin Genes inf1 and inf4 Suppresses Its Pathogenicity on Potato Plants

Journal of Fungi, 2023
Phytophthora infestans, an Oomycete pathogen, has a devastating impact on potato agriculture, leading to the extensive use of chemical fungicides to prevent its outbreaks.
Artemii A. Ivanov, Tatiana S. Golubeva
doaj   +1 more source

Blue Light Receptor PHR2‐Mediated Spectrum Antiviral Immunity

Advanced Science, EarlyView.
Blue light suppresses RBSDV through the blue‐light receptor ZmPHR2, which interacts with ZmISP in chloroplasts to trigger ROS burst and antiviral defense. The viral effector P6 enhances ZmPHR2–ZmISP interaction, alters their distribution, and suppresses ROS.
Runyi Chen, Yuxin Tai, Xinyu Wang, Chunhua Mu, Xia Liu, Gongjian Li, Jiayi Liu, Xin Lu, Duo Shi, Zhiqiang Zhou, Jienan Han, Zhuanfang Hao, Mingshun Li, Degui Zhang, Hongjun Yong, Zhennan Xu, Jianfeng Weng, Xinhai Li   +17 more
wiley   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Classification of and detection techniques for RNAi-induced effects in GM plants

Frontiers in Plant Science
RNA interference (RNAi) is a biotechnological tool used for gene silencing in plants, with both endogenous and exogenous applications. Endogenous approaches, such as host-induced gene silencing (HIGS), involve genetically modified (GM) plants, while ...
Cecilia Diaz, Steve U. Ayobahan, Samson Simon, Luise Zühl, Andreas Schiermeyer, Elke Eilebrecht, Sebastian Eilebrecht   +6 more
doaj   +1 more source