Results 1 to 10 of about 1,049,838 (245)
Spreading depression as an innate antiseizure mechanism [PDF]
Nature Communications, 2021 Spreading depression is a prolonged depolarization in the CNS associated with several neurological diseases. Here the authors demonstrate a reciprocal relationship between spreading depression and seizures in an animal model.
Isra Tamim +9 more
doaj +2 more sources
Cortical spreading depression and meningeal nociception [PDF]
Neurobiology of Pain, 2022 Migraine results in an enormous burden on individuals and societies due to its high prevalence, significant disability, and considerable economic costs.
Simone Carneiro-Nascimento, Dan Levy
doaj +2 more sources
Estrogen modulation of cortical spreading depression [PDF]
The Journal of Headache and Pain, 2023 Background and aims Cortical spreading depression (CSD), a transient neuronal and glial depolarization that propagates slowly across the cerebral cortex, is the putative electrophysiological event underlying migraine aura and a headache trigger. Migraine
Chiho Kudo +4 more
doaj +2 more sources
Mathematical Psychiatry: On Cortical Spreading Depression—A Review [PDF]
Brain Sciences, 2023 The concept of migraine with aura (MwA) is a widespread condition that can affect up to 30% of migraine patients and manifests itself as a temporary visual illusion followed by a prolonged headache. It was initially pitched as a neurological disease, and
Ejay Nsugbe
doaj +2 more sources
Mechanisms of initiation of cortical spreading depression [PDF]
The Journal of Headache and Pain, 2023 Background There is increasing evidence from human and animal studies that cortical spreading depression (CSD) is the neurophysiological correlate of migraine aura and a trigger of migraine pain mechanisms.
Marina Vitale +4 more
doaj +2 more sources
Heightened Sensitivity of the Hyperexcitable Occipital Cortex to Spreading Depression: Evidence for State-Dependent Mechanisms of Migraine Aura [PDF]
Neurology InternationalBackground/Objectives: Cortical spreading depolarization (SD) is recognized as the pathophysiological substrate of migraine aura. Suppression of ongoing cortical activity produced by SD is thought to underlie the transient neurological deficits ...
Tatiana M. Medvedeva +2 more
doaj +2 more sources
Metabolic Pathophysiology of Cortical Spreading Depression: A Review [PDF]
Brain SciencesCortical spreading depression (CSD) is an electrophysiologic pathological state in which a wave of depolarization in the cerebral cortex is followed by the suppression of spontaneous neuronal activity.
Arren Hill +12 more
doaj +2 more sources
Spreading depression as a preclinical model of migraine [PDF]
The Journal of Headache and Pain, 2019 Spreading depression (SD) is a slowly propagating wave of near-complete depolarization of neurons and glial cells across the cortex. SD is thought to contribute to the underlying pathophysiology of migraine aura, and possibly also an intrinsic brain ...
Andrea M. Harriott +3 more
doaj +2 more sources
Correction: Mechanisms of initiation of cortical spreading depression [PDF]
The Journal of Headache and Pain, 2023 Marina Vitale +4 more
doaj +2 more sources
Frontiers in Cellular Neuroscience, 2021 Spreading depolarization (SD) is a sudden, large, and synchronous depolarization of principal cells which also involves interneurons and astrocytes. It is followed by depression of neuronal activity, and it slowly propagates across brain regions like ...
Yi-Ling Lu +4 more
doaj +1 more source