Results 131 to 140 of about 28,326 (246)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Overexpression of p62/SQSTM1 increases drug resistance in both SCCHN and breast cancer cells.

, 2014
A) MCF-7 cells were transiently transfected with p62/SQSTM1 expressing vector and SCC61 cells were stably transduced with lentivirus carrying the same p62/SQSTM1 vector. Western blotting shows the ectopically expressed p62/SQSTM1-HA protein detected with
Omar Ahmed (530933), Wen-Liang Kuo (530932), Marina N. Sharifi (311843), Ezra E. W. Cohen (186351), Mark W. Lingen (250859), Kay F. Macleod (530935), Madhavi Nagilla (530934), Jing Liu (38537)   +7 more
core   +1 more source

CircHECTD1 Promotes Cholangiocarcinoma Progression Through Interaction With SFPQ to Induce Autophagy

Cancer Science, EarlyView.
CircHECTD1 directly interacts with SFPQ to upregulate ATG12 expression, thereby activating autophagy and promoting cholangiocarcinoma progression. This study uncovers a noncanonical circRNA–RNA‐binding protein regulatory mechanism and provides a potential therapeutic target for cholangiocarcinoma.
Shouwen Zhao, Shanshan Jiang, Xutong Wang, Kai Cui, Zhilei Cao, Le Zhang, Zhiqiang Wei, Yuping Ma, Han Hao, Kunpeng Zhang, Jiamin Zhang, Tianyu Dong   +11 more
wiley   +1 more source

YTHDC1 modulates the malignant phenotype of retinoblastoma via SQSTM1-mediated autophagy

Scientific Reports
Retinoblastoma (RB) is the most common pediatric intraocular malignancy, yet the role of N6-methyladenosine (m6A) regulators in RB progression remains unclear.
Jie Ding, Jie Sun, Jinghan Wang, Ruiqi Ma, Kang Xue, Jiang Qian   +5 more
doaj   +1 more source

A 3D Bioprinted Platform That Maintains the Functional Integrity of Primary AML Cells

Cell Proliferation, EarlyView.
This study presents a 3D bioprinted platform using gelatin‐hyaluronic acid hydrogels to enhance primary AML cell survival and proliferation while preserving stem‐like properties in vitro. By recapitulating in vivo‐like metabolic activity and drug resistance, this system offers a robust tool for preclinical drug screening and personalised therapy ...
Wanling Huang, Bo Deng, Nini Guo, Yiyi Ding, Zhangjingwen Xu, Yiwen Lu, Yue Ma, Qian Ren, Nan Wang, Pengyu Huang, Xiaotong Ma   +10 more
wiley   +1 more source

AFF4 Loss Compromises Osteogenesis of Orofacial Mesenchymal Stem Cells During Alveolar Bone Repair via AMPK‐Mediated Mitophagy

Cell Proliferation, EarlyView.
Compromised alveolar socket healing following tooth extraction upon Aff4 knockout is caused by suppressed osteogenic capacity of orofacial mesenchymal stem cells, which results from defective AMPK‐mediated mitophagy. ABSTRACT Repair of maxillofacial bone defects presents significant clinical challenges.
Li Zhu, Shuo Chen, Guowen Luo, Tingyue Zhang, Hengyi Lin, Yiling Chen, Chenchen Zhou, Shujuan Zou   +7 more
wiley   +1 more source

TRIM44 enhances autophagy via SQSTM1 oligomerization in response to oxidative stress

Scientific Reports
The deubiquitinase tripartite motif containing 44 (TRIM44) plays a critical role in linking the proteotoxic stress response with autophagic degradation, which is significant in the context of cancer and neurological diseases.
Yuqin Wang, Lin Lyu, Trung Vu, Nami McCarty   +3 more
doaj   +1 more source

The HECT E3 ubiquitin ligase NEDD4 interacts with and ubiquitinates SQSTM1 for inclusion body autophagy

, 2017
Our previous studies have shown that the HECT E3 ubiquitin ligase NEDD4 interacts with LC3 and is required for starvation and rapamycin-induced activation of autophagy.
Qian Dai, Hongxia Meng, Ke Peng, Genbao Shao, Wannian Yang, Jing Wei, Qiong Lin, Chandra Childress, Aiqin Sun, Miao Chen   +9 more
core   +1 more source

Novel and emerging cutaneous soft tissue tumours

Histopathology, EarlyView.
This review outlines the defining histopathological, immunophenotypic and molecular features of novel and emerging cutaneous soft tissue tumours, including hybrid superficial ALK‐rearranged myxoid spindle cell neoplasm/epithelioid fibrous histiocytoma, superficial neurocristic tumour, ALK‐rearranged epithelioid vascular neoplasm and MITF pathway ...
Saba Shafi, Josephine K Dermawan
wiley   +1 more source

Ubiquitin-induced phase separation of p62/SQSTM1 [PDF]

Cell Research, 2018
Lina, Herhaus, Ivan, Dikic
openaire   +2 more sources